ID:CATL1_HUMAN DESCRIPTION: RecName: Full=Cathepsin L1; EC=3.4.22.15; AltName: Full=Major excreted protein; Short=MEP; Contains: RecName: Full=Cathepsin L1 heavy chain; Contains: RecName: Full=Cathepsin L1 light chain; Flags: Precursor; FUNCTION: Important for the overall degradation of proteins in lysosomes. CATALYTIC ACTIVITY: Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg- NHMec, and no peptidyl-dipeptidase activity. SUBUNIT: Dimer of a heavy and a light chain linked by disulfide bonds. INTERACTION: G5EFH4:srp-6 (xeno); NbExp=2; IntAct=EBI-1220160, EBI-1549936; SUBCELLULAR LOCATION: Lysosome. SIMILARITY: Belongs to the peptidase C1 family. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CTSL1ID40208ch9q21.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P07711
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002250 adaptive immune response GO:0006508 proteolysis GO:0019882 antigen processing and presentation GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0022617 extracellular matrix disassembly GO:0030574 collagen catabolic process GO:0045616 regulation of keratinocyte differentiation GO:0051603 proteolysis involved in cellular protein catabolic process GO:0071888 macrophage apoptotic process GO:0097067 cellular response to thyroid hormone stimulus
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
