Human Gene CTXN3 (ENST00000379445.8_4) from GENCODE V47lift37
  Description: cortexin 3, transcript variant 1 (from RefSeq NM_001048252.3)
Gencode Transcript: ENST00000379445.8_4
Gencode Gene: ENSG00000205279.9_6
Transcript (Including UTRs)
   Position: hg19 chr5:126,984,774-126,994,322 Size: 9,549 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr5:126,993,214-126,993,459 Size: 246 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:126,984,774-126,994,322)mRNA (may differ from genome)Protein (81 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CTXN3_HUMAN
DESCRIPTION: RecName: Full=Cortexin-3; AltName: Full=Kidney and brain-expressed protein;
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
SIMILARITY: Belongs to the cortexin family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 10.91 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 38.07 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -136.50513-0.266 Picture PostScript Text
3' UTR -217.60863-0.252 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR020066 - Cortexin

Pfam Domains:
PF11057 - Cortexin of kidney

ModBase Predicted Comparative 3D Structure on Q4LDR2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031224 intrinsic component of membrane


-  Descriptions from all associated GenBank mRNAs
  AB219764 - Homo sapiens KABE mRNA, complete cds, clone:Kidney-DDD-17.
AB219832 - Homo sapiens KABE mRNA, complete cds, clone:K-DDD-23.
BC071790 - Homo sapiens cDNA clone IMAGE:4611512.
BC147012 - Homo sapiens cortexin 3, mRNA (cDNA clone MGC:182115 IMAGE:9056940), complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RV32, CTXN3_HUMAN, D3DQ82, ENST00000379445.1, ENST00000379445.2, ENST00000379445.3, ENST00000379445.4, ENST00000379445.5, ENST00000379445.6, ENST00000379445.7, KABE, NM_001048252, Q4LDR2, uc318ozc.1, uc318ozc.2
UCSC ID: ENST00000379445.8_4
RefSeq Accession: NM_001048252.3
Protein: Q4LDR2 (aka CTXN3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.