Human Gene CUTA (ENST00000488034.6_8) from GENCODE V47lift37
  Description: cutA divalent cation tolerance homolog, transcript variant 5 (from RefSeq NM_001014840.2)
Gencode Transcript: ENST00000488034.6_8
Gencode Gene: ENSG00000112514.18_13
Transcript (Including UTRs)
   Position: hg19 chr6:33,384,219-33,385,884 Size: 1,666 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr6:33,384,427-33,385,777 Size: 1,351 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:33,384,219-33,385,884)mRNA (may differ from genome)Protein (179 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CUTA_HUMAN
DESCRIPTION: RecName: Full=Protein CutA; AltName: Full=Acetylcholinesterase-associated protein; AltName: Full=Brain acetylcholinesterase putative membrane anchor; Flags: Precursor;
FUNCTION: May form part of a complex of membrane proteins attached to acetylcholinesterase (AChE).
SUBUNIT: Homotrimer.
INTERACTION: P22736:NR4A1; NbExp=2; IntAct=EBI-1051556, EBI-721550;
TISSUE SPECIFICITY: Ubiquitous. Widely expressed in brain.
SIMILARITY: Belongs to the CutA family.
SEQUENCE CAUTION: Sequence=AAF61220.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CUTA
Diseases sorted by gene-association score: diabetes mellitus, permanent neonatal (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 197.76 RPKM in Pituitary
Total median expression: 3627.97 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -35.40107-0.331 Picture PostScript Text
3' UTR -49.30208-0.237 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004323 - Ion_tolerance_CutA
IPR011322 - N-reg_PII-like_a/b

Pfam Domains:
PF03091 - CutA1 divalent ion tolerance protein

SCOP Domains:
54913 - GlnB-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1XK8 - X-ray MuPIT 2ZFH - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on O60888
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0019899 enzyme binding

Biological Process:
GO:0008104 protein localization
GO:0010038 response to metal ion

Cellular Component:
GO:0016020 membrane
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  KJ893945 - Synthetic construct Homo sapiens clone ccsbBroadEn_03339 CUTA gene, encodes complete protein.
AF106943 - Homo sapiens divalent cation tolerant protein CUTA mRNA, complete cds.
AF230924 - Homo sapiens brain acetylcholinesterase putative membrane anchor mRNA, complete cds.
BC005890 - Homo sapiens cutA divalent cation tolerance homolog (E. coli), mRNA (cDNA clone MGC:833 IMAGE:3505574), complete cds.
E06811 - cDNA encoding polypeptide secreted from human glioblastoma cells.
BC107751 - Homo sapiens cutA divalent cation tolerance homolog (E. coli), mRNA (cDNA clone MGC:111154 IMAGE:6714433), complete cds.
JD428103 - Sequence 409127 from Patent EP1572962.
AK311556 - Homo sapiens cDNA, FLJ18598.
JD271881 - Sequence 252905 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A2AB26, A2BEL4, ACHAP, C6orf82, CUTA_HUMAN, ENST00000488034.1, ENST00000488034.2, ENST00000488034.3, ENST00000488034.4, ENST00000488034.5, NM_001014840, O60888, Q3B784, Q5JXM9, Q5SU05, Q9NYQ9, uc322iia.1, uc322iia.2
UCSC ID: ENST00000488034.6_8
RefSeq Accession: NM_001014840.2
Protein: O60888 (aka CUTA_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.