ID:CWC15_HUMAN DESCRIPTION: RecName: Full=Spliceosome-associated protein CWC15 homolog; FUNCTION: Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. SUBUNIT: Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts directly with CTNNBL1 in the complex. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the CWC15 family. CAUTION: Has been termed C11orf5 (PubMed:10873569), but is not the official C11orf5 as defined by HGNC.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF04889 - Cwf15/Cwc15 cell cycle control protein
ModBase Predicted Comparative 3D Structure on Q9P013
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AF161497 - Homo sapiens HSPC148 mRNA, complete cds. JD094363 - Sequence 75387 from Patent EP1572962. JD379910 - Sequence 360934 from Patent EP1572962. JD385502 - Sequence 366526 from Patent EP1572962. JD469426 - Sequence 450450 from Patent EP1572962. JD253146 - Sequence 234170 from Patent EP1572962. BC040946 - Homo sapiens CWC15 spliceosome-associated protein homolog (S. cerevisiae), mRNA (cDNA clone MGC:48787 IMAGE:6067745), complete cds. AK225956 - Homo sapiens mRNA for hypothetical protein LOC51503 variant, clone: FCC114E08. AF110775 - Homo sapiens adrenal gland protein AD-002 mRNA, complete cds. AJ250393 - Homo sapiens mRNA for chromosome 11 hypothetical protein (ORF5). AK314900 - Homo sapiens cDNA, FLJ95804. HQ257942 - Synthetic construct Homo sapiens clone IMAGE:100072251 CWC15 spliceosome-associated protein homolog (S. cerevisiae) (CWC15) gene, encodes complete protein. KJ893924 - Synthetic construct Homo sapiens clone ccsbBroadEn_03318 CWC15 gene, encodes complete protein. BC032629 - Homo sapiens CWC15 spliceosome-associated protein homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:5403657), partial cds. BC006975 - Homo sapiens CWC15 spliceosome-associated protein homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:4051771), partial cds. AK309042 - Homo sapiens cDNA, FLJ99083. JD332642 - Sequence 313666 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9P013 (Reactome details) participates in the following event(s):
R-HSA-72124 Formation of the Spliceosomal A Complex R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-156661 Formation of Exon Junction Complex R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72172 mRNA Splicing R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-8953854 Metabolism of RNA
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
