ID:CXL10_HUMAN DESCRIPTION: RecName: Full=C-X-C motif chemokine 10; AltName: Full=10 kDa interferon gamma-induced protein; Short=Gamma-IP10; Short=IP-10; AltName: Full=Small-inducible cytokine B10; Contains: RecName: Full=CXCL10(1-73); Flags: Precursor; FUNCTION: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3. SUBCELLULAR LOCATION: Secreted. INDUCTION: By IFNG/IFN-gamma. A diverse population of cell types rapidly increases transcription of mRNA encoding this protein. This suggests that gamma-induced protein may be a key mediator of the IFNG/IFN-gamma response. PTM: CXCL10(1-73) is produced by proteolytic cleavage after secretion from keratinocytes. MASS SPECTROMETRY: Mass=8641.8; Method=Electrospray; Range=22-98; Source=PubMed:11559369; SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family. WEB RESOURCE: Name=Wikipedia; Note=CXCL10 entry; URL="http://en.wikipedia.org/wiki/CXCL10";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P02778
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002690 positive regulation of leukocyte chemotaxis GO:0006935 chemotaxis GO:0006952 defense response GO:0006954 inflammatory response GO:0006955 immune response GO:0007165 signal transduction GO:0007166 cell surface receptor signaling pathway GO:0007186 G-protein coupled receptor signaling pathway GO:0007267 cell-cell signaling GO:0007517 muscle organ development GO:0008015 blood circulation GO:0008284 positive regulation of cell proliferation GO:0009409 response to cold GO:0009615 response to virus GO:0010332 response to gamma radiation GO:0010469 regulation of receptor activity GO:0010818 T cell chemotaxis GO:0010819 regulation of T cell chemotaxis GO:0010996 response to auditory stimulus GO:0016525 negative regulation of angiogenesis GO:0019221 cytokine-mediated signaling pathway GO:0030335 positive regulation of cell migration GO:0030816 positive regulation of cAMP metabolic process GO:0031640 killing of cells of other organism GO:0032496 response to lipopolysaccharide GO:0033280 response to vitamin D GO:0034605 cellular response to heat GO:0042118 endothelial cell activation GO:0042127 regulation of cell proliferation GO:0043950 positive regulation of cAMP-mediated signaling GO:0045662 negative regulation of myoblast differentiation GO:0045859 regulation of protein kinase activity GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0051281 positive regulation of release of sequestered calcium ion into cytosol GO:0051607 defense response to virus GO:0070098 chemokine-mediated signaling pathway GO:0071222 cellular response to lipopolysaccharide GO:0090026 positive regulation of monocyte chemotaxis GO:1901509 regulation of endothelial tube morphogenesis GO:1901740 negative regulation of myoblast fusion GO:2000406 positive regulation of T cell migration
Cellular Component: GO:0005576 extracellular region GO:0005615 extracellular space GO:0009897 external side of plasma membrane
Descriptions from all associated GenBank mRNAs
BC010954 - Homo sapiens chemokine (C-X-C motif) ligand 10, mRNA (cDNA clone MGC:13622 IMAGE:4274617), complete cds. LP880246 - Sequence 50 from Patent WO2017181111. LP882075 - Sequence 17 from Patent WO2017181079. LQ878891 - Sequence 6 from Patent WO2018154075. LQ882910 - Sequence 59 from Patent WO2018160841. X02530 - Homo sapiens mRNA for gamma-interferon inducible early response polypeptide precursor. JD447430 - Sequence 428454 from Patent EP1572962. JD434711 - Sequence 415735 from Patent EP1572962. JD355123 - Sequence 336147 from Patent EP1572962. JD246595 - Sequence 227619 from Patent EP1572962. JD438949 - Sequence 419973 from Patent EP1572962. KJ897060 - Synthetic construct Homo sapiens clone ccsbBroadEn_06454 CXCL10 gene, encodes complete protein. DQ892786 - Synthetic construct clone IMAGE:100005416; FLH189719.01X; RZPDo839A0675D chemokine (C-X-C motif) ligand 10 (CXCL10) gene, encodes complete protein. DQ896033 - Synthetic construct Homo sapiens clone IMAGE:100010493; FLH189715.01L; RZPDo839A0665D chemokine (C-X-C motif) ligand 10 (CXCL10) gene, encodes complete protein. AB529178 - Synthetic construct DNA, clone: pF1KB6739, Homo sapiens CXCL10 gene for chemokine (C-X-C motif) ligand 10, without stop codon, in Flexi system. JD306789 - Sequence 287813 from Patent EP1572962. JD468160 - Sequence 449184 from Patent EP1572962. LQ927254 - Sequence 31 from Patent WO2018191660. MP067521 - Sequence 25 from Patent WO2018232288. MP202736 - Sequence 47 from Patent WO2019090263. MB143798 - JP 2019515670-A/9: METHODS FOR MONITORING AND TREATING CANCER. MB423122 - JP 2019521641-A/9: METHODS FOR MONITORING AND TREATING CANCER. MP584560 - Sequence 59 from Patent WO2020081767.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P02778 (Reactome details) participates in the following event(s):
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
