Human Gene CXCL9 (ENST00000264888.6_7) from GENCODE V47lift37

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Description: C-X-C motif chemokine ligand 9 (from RefSeq NM_002416.3)
Gencode Transcript: ENST00000264888.6_7
Gencode Gene: ENSG00000138755.6_9
Transcript (Including UTRs)
Position: hg19 chr4:76,922,428-76,928,662 Size: 6,235 Total Exon Count: 4 Strand: -
Coding Region
Position: hg19 chr4:76,924,751-76,928,602 Size: 3,852 Coding Exon Count: 4

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr4:76,922,428-76,928,662)			mRNA (may differ from genome)		Protein (125 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	Reactome
UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: CXCL9_HUMAN DESCRIPTION: RecName: Full=C-X-C motif chemokine 9; AltName: Full=Gamma-interferon-induced monokine; AltName: Full=Monokine induced by interferon-gamma; Short=HuMIG; Short=MIG; AltName: Full=Small-inducible cytokine B9; Flags: Precursor; FUNCTION: Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3. SUBCELLULAR LOCATION: Secreted. INDUCTION: By IFNG/IFN-gamma. The induction is enhanced by TNF in dermal fibroblasts and vein endothelial cells. SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family. WEB RESOURCE: Name=Wikipedia; Note=CXCL9 entry; URL="http://en.wikipedia.org/wiki/CXCL9";

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
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Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: CXCL9 Diseases sorted by gene-association score: endotheliitis (5), sydenham chorea (5), inclusion body myositis (5), mycosis fungoides (4), lichen planus (4), encephalitis (4), malaria (3), opsoclonus-myoclonus syndrome (3), lymphomatoid granulomatosis (3), sarcoidosis 1 (2), scleredema adultorum (2), pulmonary fibrosis, idiopathic (2), endocervicitis (2), myasthenic syndrome, congenital, 7, presynaptic (2), mucinoses (1), multiple sclerosis, disease progression, modifier of (1), non-secretory myeloma (1), carrion's disease (1), pleuropneumonia (1), immunodeficiency with hyper-igm, type 2 (1), chilblain lupus (1), primary syphilis (1)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D008070 Lipopolysaccharides D010081 Oxazolone D013749 Tetrachlorodibenzodioxin C059514 resveratrol C017947 sodium arsenite C020888 1,2-dielaidoylphosphatidylethanolamine C070046 1,2-dioleoyloxy-3-(trimethylammonium)propane C014024 2,4,5,2',4',5'-hexachlorobiphenyl C017906 3-dinitrobenzene C009505 4,4'-diaminodiphenylmethane D015112 4-Nitroquinoline-1-oxide D000082 Acetaminophen D000643 Ammonium Chloride D001205 Ascorbic Acid D016589 Astemizole D001564 Benzo(a)pyrene D019256 Cadmium Chloride D002118 Calcium D002784 Cholesterol D003042 Cocaine D003436 Croton Oil D003520 Cyclophosphamide D003907 Dexamethasone D004041 Dietary Fats D004054 Diethylstilbestrol D004128 Dimethylnitrosamine D004997 Ethinyl Estradiol D007545 Isoproterenol D047311 Luteolin D009183 Mycotoxins D037342 Pertussis Toxin D010634 Phenobarbital D011070 Poly I-C D017382 Reactive Oxygen Species D012406 Roxarsone D012643 Selenium D012822 Silicon Dioxide D012964 Sodium D053260 Soot D013241 Sterigmatocystin D013467 Sulindac C402696 TMC 120A D013739 Testosterone D013755 Tetradecanoylphorbol Acetate D014028 Tobacco Smoke Pollution D014051 Toluene 2,4-Diisocyanate D014118 Toxins, Biological D014212 Tretinoin D014302 Trinitrobenzenesulfonic Acid D014303 Trinitrotoluene D015034 Zinc Oxide D015054 Zymosan C496492 abrine C006418 adrenocorticotropin zinc C064176 alpha-viniferin C004984 apocarotenal C006632 arsenic trioxide D019207 beta Carotene C483161 beta-hydroxy simvastatin acid C038459 curdlan C014347 decitabine C007262 deoxynivalenol C014476 diethyl maleate C044101 endotoxin, Escherichia coli C007630 estradiol 17 beta-cypionate C064925 gadodiamide C007834 genipin C097613 imatinib C016517 indole-3-carbinol C008435 methyldithiocarbamate C015380 neoechinulin C022838 nickel chloride C028007 nickel monoxide C012655 nimesulide C041786 palm oil C011272 perfosfamide C006253 pirinixic acid C089730 rosiglitazone C061133 tamibarotene C009495 titanium dioxide C015559 trimellitic anhydride C066075 vanadium pentoxide

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 3.50 RPKM in Lung Total median expression: 25.81 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-11.00	60	-0.183	Picture	PostScript	Text
3' UTR	-583.28	2323	-0.251	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001089 - Chemokine_CXC
IPR018048 - Chemokine_CXC_CS
IPR001811 - Chemokine_IL8-like_dom

Pfam Domains:
PF00048 - Small cytokines (intecrine/chemokine), interleukin-8 like

SCOP Domains:
54117 - Interleukin 8-like chemokines

ModBase Predicted Comparative 3D Structure on Q07325


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005125 cytokine activity GO:0005515 protein binding GO:0008009 chemokine activity GO:0048248 CXCR3 chemokine receptor binding Biological Process: GO:0002690 positive regulation of leukocyte chemotaxis GO:0006935 chemotaxis GO:0006952 defense response GO:0006954 inflammatory response GO:0006955 immune response GO:0006968 cellular defense response GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0007267 cell-cell signaling GO:0010469 regulation of receptor activity GO:0010818 T cell chemotaxis GO:0030816 positive regulation of cAMP metabolic process GO:0031640 killing of cells of other organism GO:0032496 response to lipopolysaccharide GO:0042127 regulation of cell proliferation GO:0043950 positive regulation of cAMP-mediated signaling GO:0045663 positive regulation of myoblast differentiation GO:0051281 positive regulation of release of sequestered calcium ion into cytosol GO:0051607 defense response to virus GO:0070098 chemokine-mediated signaling pathway GO:1901741 positive regulation of myoblast fusion Cellular Component: GO:0005576 extracellular region GO:0005615 extracellular space GO:0009897 external side of plasma membrane

Descriptions from all associated GenBank mRNAs


	BC042178 - Homo sapiens chemokine (C-X-C motif) ligand 9, mRNA (cDNA clone IMAGE:5228247). BC025745 - Homo sapiens cDNA clone IMAGE:5228354. BC063122 - Homo sapiens chemokine (C-X-C motif) ligand 9, mRNA (cDNA clone MGC:71972 IMAGE:30370826), complete cds. BC095396 - Homo sapiens chemokine (C-X-C motif) ligand 9, mRNA (cDNA clone MGC:110863 IMAGE:30336410), complete cds. LP880244 - Sequence 48 from Patent WO2017181111. LP882073 - Sequence 15 from Patent WO2017181079. LQ882908 - Sequence 57 from Patent WO2018160841. X72755 - H.sapiens Humig mRNA. JD097782 - Sequence 78806 from Patent EP1572962. JD082497 - Sequence 63521 from Patent EP1572962. JD382138 - Sequence 363162 from Patent EP1572962. JD252774 - Sequence 233798 from Patent EP1572962. JD350877 - Sequence 331901 from Patent EP1572962. JD077019 - Sequence 58043 from Patent EP1572962. JD380144 - Sequence 361168 from Patent EP1572962. JD296207 - Sequence 277231 from Patent EP1572962. JD231267 - Sequence 212291 from Patent EP1572962. JD382877 - Sequence 363901 from Patent EP1572962. JD556822 - Sequence 537846 from Patent EP1572962. JD433590 - Sequence 414614 from Patent EP1572962. JD202166 - Sequence 183190 from Patent EP1572962. JD054299 - Sequence 35323 from Patent EP1572962. JD165936 - Sequence 146960 from Patent EP1572962. JD097021 - Sequence 78045 from Patent EP1572962. JD539336 - Sequence 520360 from Patent EP1572962. JD050202 - Sequence 31226 from Patent EP1572962. JD107254 - Sequence 88278 from Patent EP1572962. JD465782 - Sequence 446806 from Patent EP1572962. JD241156 - Sequence 222180 from Patent EP1572962. JD504608 - Sequence 485632 from Patent EP1572962. JD197434 - Sequence 178458 from Patent EP1572962. AK311852 - Homo sapiens cDNA, FLJ92117, highly similar to Homo sapiens chemokine (C-X-C motif) ligand 9 (CXCL9), mRNA. CU687652 - Synthetic construct Homo sapiens gateway clone IMAGE:100022352 5' read CXCL9 mRNA. HQ447615 - Synthetic construct Homo sapiens clone IMAGE:100070961; CCSB013382_01 chemokine (C-X-C motif) ligand 9 (CXCL9) gene, encodes complete protein. KJ891620 - Synthetic construct Homo sapiens clone ccsbBroadEn_01014 CXCL9 gene, encodes complete protein. AB590958 - Synthetic construct DNA, clone: pFN21AE1613, Homo sapiens CXCL9 gene for chemokine (C-X-C motif) ligand 9, without stop codon, in Flexi system. JD247276 - Sequence 228300 from Patent EP1572962. LQ927230 - Sequence 7 from Patent WO2018191660. MP202734 - Sequence 45 from Patent WO2019090263. MB143797 - JP 2019515670-A/8: METHODS FOR MONITORING AND TREATING CANCER. MB423121 - JP 2019521641-A/8: METHODS FOR MONITORING AND TREATING CANCER. MP584558 - Sequence 57 from Patent WO2020081767.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q07325 (Reactome details) participates in the following event(s): R-HSA-374248 Receptor CXCR3 binds ligands CXCL9 to 11 R-HSA-749454 The Ligand:GPCR:Gi complex dissociates R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi R-HSA-380108 Chemokine receptors bind chemokines R-HSA-418594 G alpha (i) signalling events R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signalling R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-372790 Signaling by GPCR R-HSA-500792 GPCR ligand binding R-HSA-162582 Signal Transduction

Other Names for This Gene


	Alternate Gene Symbols: CMK, CXCL9_HUMAN, ENST00000264888.1, ENST00000264888.2, ENST00000264888.3, ENST00000264888.4, ENST00000264888.5, MIG, NM_002416, Q07325, Q503B4, SCYB9, uc317hwk.1, uc317hwk.2 UCSC ID: ENST00000264888.6_7 RefSeq Accession: NM_002416.3 Protein: Q07325 (aka CXCL9_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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