Human Gene CYP1A1 (ENST00000379727.8_8) from GENCODE V47lift37
  Description: cytochrome P450 family 1 subfamily A member 1, transcript variant 3 (from RefSeq NM_001319217.2)
Gencode Transcript: ENST00000379727.8_8
Gencode Gene: ENSG00000140465.15_11
Transcript (Including UTRs)
   Position: hg19 chr15:75,011,883-75,017,869 Size: 5,987 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr15:75,012,830-75,015,438 Size: 2,609 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:75,011,883-75,017,869)mRNA (may differ from genome)Protein (512 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CP1A1_HUMAN
DESCRIPTION: RecName: Full=Cytochrome P450 1A1; EC=1.14.14.1; AltName: Full=CYPIA1; AltName: Full=Cytochrome P450 form 6; AltName: Full=Cytochrome P450-C; AltName: Full=Cytochrome P450-P1;
FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
CATALYTIC ACTIVITY: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.
COFACTOR: Heme group (By similarity).
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
TISSUE SPECIFICITY: Lung, lymphocytes and placenta.
INDUCTION: By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
SIMILARITY: Belongs to the cytochrome P450 family.
WEB RESOURCE: Name=Cytochrome P450 Allele Nomenclature Committee; Note=CYP1A1 alleles; URL="http://www.cypalleles.ki.se/cyp1a1.htm";
WEB RESOURCE: Name=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=CYP1A1";
WEB RESOURCE: Name=Wikipedia; Note=CYP1A1 entry; URL="http://en.wikipedia.org/wiki/CYP1A1";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CYP1A1
Diseases sorted by gene-association score: ehrlich tumor carcinoma (15), lung squamous cell carcinoma (14), oral cavity cancer (10), oral cancer (9), oral submucous fibrosis (9), hepatocellular adenoma (8), basal cell carcinoma, multiple (7), lung cancer (7), female breast cancer (7), leukoplakia (7), breast disease (6), orofacial cleft (6), acne (6), balkan nephropathy (6), squamous cell carcinoma (6), childhood leukemia (6), toxic oil syndrome (5), clopidogrel resistance (5), conjunctival degeneration (4), pulmonary immaturity (4), acneiform dermatitis (4), pinguecula (4), lymphoblastic leukemia (4), esophageal cancer (3), breast cancer (3), hepatocellular carcinoma (2), colorectal cancer (2), breast adenocarcinoma (2), testicular germ cell tumor (2), lung cancer susceptibility 3 (2), prostate cancer susceptibility (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.87 RPKM in Skin - Sun Exposed (Lower leg)
Total median expression: 22.38 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -23.70117-0.203 Picture PostScript Text
3' UTR -338.90947-0.358 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001128 - Cyt_P450
IPR017972 - Cyt_P450_CS
IPR002401 - Cyt_P450_E_grp-I
IPR008066 - Cyt_P450_E_grp-I_CYP1

Pfam Domains:
PF00067 - Cytochrome P450

SCOP Domains:
48264 - Cytochrome P450
48371 - ARM repeat

ModBase Predicted Comparative 3D Structure on P04798
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003824 catalytic activity
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0008395 steroid hydroxylase activity
GO:0016491 oxidoreductase activity
GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016711 flavonoid 3'-monooxygenase activity
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0019825 oxygen binding
GO:0019899 enzyme binding
GO:0020037 heme binding
GO:0032451 demethylase activity
GO:0046872 metal ion binding
GO:0070330 aromatase activity
GO:0070576 vitamin D 24-hydroxylase activity
GO:0101020 estrogen 16-alpha-hydroxylase activity

Biological Process:
GO:0001666 response to hypoxia
GO:0001889 liver development
GO:0002933 lipid hydroxylation
GO:0006778 porphyrin-containing compound metabolic process
GO:0007568 aging
GO:0008202 steroid metabolic process
GO:0008283 cell proliferation
GO:0009308 amine metabolic process
GO:0009404 toxin metabolic process
GO:0009611 response to wounding
GO:0009615 response to virus
GO:0009624 response to nematode
GO:0009635 response to herbicide
GO:0009636 response to toxic substance
GO:0009692 ethylene metabolic process
GO:0009804 coumarin metabolic process
GO:0009812 flavonoid metabolic process
GO:0010033 response to organic substance
GO:0010041 response to iron(III) ion
GO:0014070 response to organic cyclic compound
GO:0017143 insecticide metabolic process
GO:0017144 drug metabolic process
GO:0018894 dibenzo-p-dioxin metabolic process
GO:0019216 regulation of lipid metabolic process
GO:0019341 dibenzo-p-dioxin catabolic process
GO:0019373 epoxygenase P450 pathway
GO:0032094 response to food
GO:0032496 response to lipopolysaccharide
GO:0032502 developmental process
GO:0033189 response to vitamin A
GO:0035902 response to immobilization stress
GO:0042359 vitamin D metabolic process
GO:0042493 response to drug
GO:0042759 long-chain fatty acid biosynthetic process
GO:0042904 9-cis-retinoic acid biosynthetic process
GO:0043010 camera-type eye development
GO:0046483 heterocycle metabolic process
GO:0046677 response to antibiotic
GO:0046685 response to arsenic-containing substance
GO:0048565 digestive tract development
GO:0050665 hydrogen peroxide biosynthetic process
GO:0055093 response to hyperoxia
GO:0055114 oxidation-reduction process
GO:0060137 maternal process involved in parturition
GO:0070365 hepatocyte differentiation
GO:0070988 demethylation
GO:0071280 cellular response to copper ion
GO:0071407 cellular response to organic cyclic compound
GO:0097267 omega-hydroxylase P450 pathway
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle

Cellular Component:
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0031090 organelle membrane
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  BC023019 - Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 1, mRNA (cDNA clone MGC:29888 IMAGE:5123393), complete cds.
LF208519 - JP 2014500723-A/16022: Polycomb-Associated Non-Coding RNAs.
K03191 - Human cytochrome P-1-450 (TCDD-inducible) mRNA, complete cds.
JD303122 - Sequence 284146 from Patent EP1572962.
JD428934 - Sequence 409958 from Patent EP1572962.
JD373673 - Sequence 354697 from Patent EP1572962.
JD423272 - Sequence 404296 from Patent EP1572962.
JD555753 - Sequence 536777 from Patent EP1572962.
JD098910 - Sequence 79934 from Patent EP1572962.
JD188735 - Sequence 169759 from Patent EP1572962.
JD470962 - Sequence 451986 from Patent EP1572962.
AK310810 - Homo sapiens cDNA, FLJ17852.
JD477367 - Sequence 458391 from Patent EP1572962.
AH007293 - Homo sapiens cytochrome P450 1A1 (CYP1A1) mRNA, partial cds.
JD175082 - Sequence 156106 from Patent EP1572962.
JD400488 - Sequence 381512 from Patent EP1572962.
AK223113 - Homo sapiens mRNA for cytochrome P450, family 1, subfamily A, polypeptide 1 variant, clone: KAT09250.
JD482187 - Sequence 463211 from Patent EP1572962.
JD399774 - Sequence 380798 from Patent EP1572962.
AK223108 - Homo sapiens mRNA for cytochrome P450, family 1, subfamily A, polypeptide 1 variant, clone: KAT07566.
AM236046 - Homo sapiens mRNA for cytochrome P450 1A1 (CYP1A1 gene), splice variant 5.
AM236047 - Homo sapiens mRNA for cytochrome P450 1A1 (CYP1A1 gene), splice variant 6.
JD479689 - Sequence 460713 from Patent EP1572962.
AY871801 - Homo sapiens cytochrome P450 family 1 subfamily A polypeptide 1 (CYP1A1) mRNA, complete cds, alternatively spliced.
JD266306 - Sequence 247330 from Patent EP1572962.
DQ891515 - Synthetic construct clone IMAGE:100004145; FLH177640.01X; RZPDo839C05126D cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) gene, encodes complete protein.
AY310359 - Homo sapiens cytochrome P450 1A1 variant (CYP1A1) mRNA, complete cds; alternatively spliced.
E10856 - cDNA encoding human cytochrome P450.
E10857 - cDNA encoding human cytochrome P450.
E10858 - cDNA encoding human cytochrome P450.
E11493 - cDNA encoding human cytochrome P-4501A1.
AK313880 - Homo sapiens cDNA, FLJ94514, Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 1(CYP1A1), mRNA.
KJ891012 - Synthetic construct Homo sapiens clone ccsbBroadEn_00406 CYP1A1 gene, encodes complete protein.
KR710640 - Synthetic construct Homo sapiens clone CCSBHm_00015154 CYP1A1 (CYP1A1) mRNA, encodes complete protein.
KR710641 - Synthetic construct Homo sapiens clone CCSBHm_00015155 CYP1A1 (CYP1A1) mRNA, encodes complete protein.
DQ894706 - Synthetic construct Homo sapiens clone IMAGE:100009166; FLH177636.01L; RZPDo839C05125D cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) gene, encodes complete protein.
M12079 - Human cytochrome P-450 6 mRNA, partial cds.
AM233517 - Homo sapiens partial mRNA for cytochrome P450 1A1 (CYP1A1 gene), alternative splice variant 1.
AM233518 - Homo sapiens mRNA for cytochrome P450 1A1 (CYP1A1 gene), alternative splice variant 2.
AM233519 - Homo sapiens mRNA for cytochrome P450 1A1 (CYP1A1 gene), alternative splice variant 3.
AM233520 - Homo sapiens mRNA for cytochrome P450 1A1 (CYP1A1 gene), alternative splice variant 4.
CU692778 - Synthetic construct Homo sapiens gateway clone IMAGE:100019740 5' read CYP1A1 mRNA.
LF377234 - JP 2014500723-A/184737: Polycomb-Associated Non-Coding RNAs.
JD493249 - Sequence 474273 from Patent EP1572962.
JD380587 - Sequence 361611 from Patent EP1572962.
JD119197 - Sequence 100221 from Patent EP1572962.
MA444096 - JP 2018138019-A/16022: Polycomb-Associated Non-Coding RNAs.
MA612811 - JP 2018138019-A/184737: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P04798 (Reactome details) participates in the following event(s):

R-HSA-76472 Ethylene is oxidized to Ethylene oxide by CYP1A1
R-HSA-2161814 Arachidonic acid is hydroxylated to 19-HETE by CYP(2)
R-HSA-2161890 Arachidonic acid is epoxidated to 5,6-EET by CYP(4)
R-HSA-2161940 Arachidonic acid is hydroxylated to 20-HETE by CYP(3)
R-HSA-2161899 Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)
R-HSA-2161795 Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1)
R-HSA-9037761 CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1
R-HSA-1989781 PPARA activates gene expression
R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-211981 Xenobiotics
R-HSA-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
R-HSA-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
R-HSA-9018681 Biosynthesis of protectins
R-HSA-556833 Metabolism of lipids
R-HSA-211897 Cytochrome P450 - arranged by substrate type
R-HSA-2142753 Arachidonic acid metabolism
R-HSA-9018677 Biosynthesis of DHA-derived SPMs
R-HSA-1430728 Metabolism
R-HSA-211945 Phase I - Functionalization of compounds
R-HSA-8978868 Fatty acid metabolism
R-HSA-9018678 Biosynthesis of specialized proresolving mediators (SPMs)
R-HSA-211859 Biological oxidations

-  Other Names for This Gene
  Alternate Gene Symbols: A4F3V9, A4F3W0, CP1A1_HUMAN, CYP1A1 , ENST00000379727.1, ENST00000379727.2, ENST00000379727.3, ENST00000379727.4, ENST00000379727.5, ENST00000379727.6, ENST00000379727.7, NM_001319217, P04798, Q53G18, uc318pdv.1, uc318pdv.2
UCSC ID: ENST00000379727.8_8
RefSeq Accession: NM_001319217.2
Protein: P04798 (aka CP1A1_HUMAN or CP11_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.