ID:CP2B6_HUMAN DESCRIPTION: RecName: Full=Cytochrome P450 2B6; EC=1.14.13.-; AltName: Full=1,4-cineole 2-exo-monooxygenase; AltName: Full=CYPIIB6; AltName: Full=Cytochrome P450 IIB1; FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase. CATALYTIC ACTIVITY: 1,4-cineole + NADPH + O(2) = 2-exo-hydroxy- 1,4-cineole + NADP(+) + H(2)O. COFACTOR: Heme group. COFACTOR: Heme group (By similarity). BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=360 uM for 1,4-cineole; Vmax=3.4 nmol/min/nmol enzyme toward 2-exo-hydroxy-1,4-cineole; SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. TISSUE SPECIFICITY: Expressed in liver, lung and heart right ventricle. INDUCTION: By phenobarbital. PTM: Phosphorylation is accompanied by a decrease in enzyme activity (By similarity). POLYMORPHISM: Genetic variations in CYP2B6 are responsible for poor metabolism of efavirenz and, therefore, susceptibility to efavirenz toxicity in the central nervous system [MIM:614546]. Efavirenz is a non-nucleoside reverse transcriptase inhibitor frequently prescribed with 2 nucleoside reverse transcriptase inhibitors as initial therapy for human immunodeficiency virus (HIV) infection. Up to half of patients treated with efavirenz, experience side effects in the central nervous system, including dizziness, insomnia, impaired concentration, somnolence, and abnormal dreams. Severe depression, aggressive behavior, and paranoid or manic reactions may also occur, depending on efavirenz concentration in the plasma. SIMILARITY: Belongs to the cytochrome P450 family. WEB RESOURCE: Name=Cytochrome P450 Allele Nomenclature Committee; Note=CYP2B6 alleles; URL="http://www.cypalleles.ki.se/cyp2b6.htm"; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cyp2b6/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P20813
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004497 monooxygenase activity GO:0005506 iron ion binding GO:0008392 arachidonic acid epoxygenase activity GO:0008395 steroid hydroxylase activity GO:0016491 oxidoreductase activity GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0020037 heme binding GO:0046872 metal ion binding
Biological Process: GO:0006805 xenobiotic metabolic process GO:0008202 steroid metabolic process GO:0017144 drug metabolic process GO:0019373 epoxygenase P450 pathway GO:0042180 cellular ketone metabolic process GO:0042738 exogenous drug catabolic process GO:0055114 oxidation-reduction process
BioCarta from NCI Cancer Genome Anatomy Project h_nuclearRsPathway - Nuclear Receptors in Lipid Metabolism and Toxicity
Reactome (by CSHL, EBI, and GO)
Protein P20813 (Reactome details) participates in the following event(s):
R-HSA-211991 Cyclophosphamide is 4-hydroxylated by CYP2B6 R-HSA-76354 Vinyl chloride is oxidized to 2-Chloroethylene oxide R-HSA-76397 Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) R-HSA-76416 Benzene is hydroxylated to phenol R-HSA-76434 Dehalogenation of carbon tetrachloride to form a free radical R-HSA-76475 Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide R-HSA-143468 MEOS oxidizes ethanol to acetaldehyde R-HSA-211910 CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation R-HSA-211988 CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation R-HSA-212005 CYP2F1 dehydrogenates 3-methylindole R-HSA-211929 CYP2C19 5-hydroxylates omeprazole R-HSA-211983 CYP2J2 oxidises ARA R-HSA-211881 Coumarin is 7-hydroxylated by CYP2A13 R-HSA-211981 Xenobiotics R-HSA-211999 CYP2E1 reactions R-HSA-211935 Fatty acids R-HSA-211897 Cytochrome P450 - arranged by substrate type R-HSA-211945 Phase I - Functionalization of compounds R-HSA-211859 Biological oxidations R-HSA-1430728 Metabolism
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
