The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P05181
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004497 monooxygenase activity GO:0005506 iron ion binding GO:0008392 arachidonic acid epoxygenase activity GO:0008395 steroid hydroxylase activity GO:0016491 oxidoreductase activity GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0019825 oxygen binding GO:0019899 enzyme binding GO:0020037 heme binding GO:0046872 metal ion binding
Biological Process: GO:0006641 triglyceride metabolic process GO:0006805 xenobiotic metabolic process GO:0008202 steroid metabolic process GO:0010193 response to ozone GO:0010243 response to organonitrogen compound GO:0016098 monoterpenoid metabolic process GO:0017144 drug metabolic process GO:0018885 carbon tetrachloride metabolic process GO:0018910 benzene metabolic process GO:0019373 epoxygenase P450 pathway GO:0042197 halogenated hydrocarbon metabolic process GO:0042493 response to drug GO:0042759 long-chain fatty acid biosynthetic process GO:0045471 response to ethanol GO:0046483 heterocycle metabolic process GO:0055114 oxidation-reduction process
AK290822 - Homo sapiens cDNA FLJ75676 complete cds, highly similar to Homo sapiens cytochrome P450, family 2, subfamily E, polypeptide 1(CYP2E1), mRNA. J02625 - Human cytochrome P-450j mRNA, complete cds. AF182276 - Homo sapiens cytochrome P450-2E1 (CYP2E1) mRNA, complete cds. JD461066 - Sequence 442090 from Patent EP1572962. DQ149222 - Homo sapiens cytochrome P450 2E1 mRNA, partial cds. BC067435 - Homo sapiens cytochrome P450, family 2, subfamily E, polypeptide 1, mRNA (cDNA clone MGC:79262 IMAGE:7002164), complete cds. CU688292 - Synthetic construct Homo sapiens gateway clone IMAGE:100023206 5' read CYP2E1 mRNA. KJ896681 - Synthetic construct Homo sapiens clone ccsbBroadEn_06075 CYP2E1 gene, encodes complete protein. KR711441 - Synthetic construct Homo sapiens clone CCSBHm_00023557 CYP2E1 (CYP2E1) mRNA, encodes complete protein. BC067433 - Homo sapiens cytochrome P450, family 2, subfamily E, polypeptide 1, mRNA (cDNA clone MGC:79260 IMAGE:7002160), complete cds. E10621 - Human cDNA encoding cytochrome P4502E1. E10854 - cDNA encoding human cytochrome P450. AF084225 - Homo sapiens cytochrome P450 2E1 (CYP2E1) mRNA, partial cds. AJ853939 - Homo sapiens partial mRNA for cytochrome P450 2E1 (CYP2E1 gene), isoform 1. AJ853940 - Homo sapiens partial mRNA for cytochrome P450 2E1 (CYP2E1 gene), isoform 2. AJ877238 - Homo sapiens partial mRNA for putative cytochrome P450 2E1 (CYP2E1 gene), isoform 3. AB209700 - Homo sapiens mRNA for cytochrome P450, family 2, subfamily E, polypeptide 1 variant protein. JD021500 - Sequence 2524 from Patent EP1572962. JD028214 - Sequence 9238 from Patent EP1572962. S77873 - CYP2E1=cytochrome P450A {3' region} [human, liver, mRNA Partial, 346 nt]. JD020750 - Sequence 1774 from Patent EP1572962. JD028598 - Sequence 9622 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCyc Knowledge Library PWY-5451 - acetone degradation I (to methylglyoxal) PWY-5453 - methylglyoxal degradation III PWY-7466 - acetone degradation III (to propane-1,2-diol) PWY-7926 - carbon disulfide oxidation III (metazoa) PWY66-161 - ethanol degradation III
BioCarta from NCI Cancer Genome Anatomy Project h_AcetaminophenPathway - Mechanism of Acetaminophen Activity and Toxicity h_nuclearRsPathway - Nuclear Receptors in Lipid Metabolism and Toxicity
Reactome (by CSHL, EBI, and GO)
Protein P05181 (Reactome details) participates in the following event(s):
R-HSA-9027302 CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA R-HSA-9027321 CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA R-HSA-76354 Vinyl chloride is oxidized to 2-Chloroethylene oxide R-HSA-76397 Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) R-HSA-76416 Benzene is hydroxylated to phenol R-HSA-76434 Dehalogenation of carbon tetrachloride to form a free radical R-HSA-76475 Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide R-HSA-143468 MEOS oxidizes ethanol to acetaldehyde R-HSA-9027043 CYPs hydroxylate DHA to 14(R)-HDHA R-HSA-211910 CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation R-HSA-76456 O-atom dealkylation of dextromethorphan R-HSA-211966 CYP2D6 4-hydroxylates debrisoquine R-HSA-76453 Coumarin is 7-hydroxylated by CYP2A6 R-HSA-211988 CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation R-HSA-211991 Cyclophosphamide is 4-hydroxylated by CYP2B6 R-HSA-212005 CYP2F1 dehydrogenates 3-methylindole R-HSA-211929 CYP2C19 5-hydroxylates omeprazole R-HSA-211881 Coumarin is 7-hydroxylated by CYP2A13 R-HSA-9027307 Biosynthesis of maresin-like SPMs R-HSA-211999 CYP2E1 reactions R-HSA-211981 Xenobiotics R-HSA-9018682 Biosynthesis of maresins R-HSA-211897 Cytochrome P450 - arranged by substrate type R-HSA-9018677 Biosynthesis of DHA-derived SPMs R-HSA-211945 Phase I - Functionalization of compounds R-HSA-9018678 Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-211859 Biological oxidations R-HSA-8978868 Fatty acid metabolism R-HSA-1430728 Metabolism R-HSA-556833 Metabolism of lipids
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
