Human Gene CYP4A11 (ENST00000310638.9_10) from GENCODE V47lift37
  Description: cytochrome P450 family 4 subfamily A member 11, transcript variant 9 (from RefSeq NR_134994.2)
Gencode Transcript: ENST00000310638.9_10
Gencode Gene: ENSG00000187048.14_13
Transcript (Including UTRs)
   Position: hg19 chr1:47,394,860-47,407,148 Size: 12,289 Total Exon Count: 12 Strand: -
Coding Region
   Position: hg19 chr1:47,395,787-47,407,105 Size: 11,319 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:47,394,860-47,407,148)mRNA (may differ from genome)Protein (519 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CP4AB_HUMAN
DESCRIPTION: RecName: Full=Cytochrome P450 4A11; AltName: Full=20-hydroxyeicosatetraenoic acid synthase; Short=20-HETE synthase; AltName: Full=CYP4AII; AltName: Full=CYPIVA11; AltName: Full=Cytochrome P-450HK-omega; AltName: Full=Cytochrome P450HL-omega; AltName: Full=Fatty acid omega-hydroxylase; AltName: Full=Lauric acid omega-hydroxylase; EC=1.14.15.3; Flags: Precursor;
FUNCTION: Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE).
CATALYTIC ACTIVITY: Octane + reduced rubredoxin + O(2) = 1-octanol + oxidized rubredoxin + H(2)O.
COFACTOR: Heme group (By similarity).
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
TISSUE SPECIFICITY: Kidney and liver.
POLYMORPHISM: CYP4A11v seems to be a rare allelic variant of CYP4A11, it seems to be unstable and not to metabolize lauric acid.
SIMILARITY: Belongs to the cytochrome P450 family.
WEB RESOURCE: Name=Cytochrome P450 Allele Nomenclature Committee; Note=CYP4A11 alleles; URL="http://www.cypalleles.ki.se/cyp4a11.htm";
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/cyp4a11/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CYP4A11
Diseases sorted by gene-association score: generalized atherosclerosis (11), chromosome 17q12 deletion syndrome (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 155.03 RPKM in Liver
Total median expression: 186.25 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -10.7043-0.249 Picture PostScript Text
3' UTR -219.80927-0.237 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001128 - Cyt_P450
IPR017972 - Cyt_P450_CS
IPR002401 - Cyt_P450_E_grp-I

Pfam Domains:
PF00067 - Cytochrome P450

SCOP Domains:
48264 - Cytochrome P450

ModBase Predicted Comparative 3D Structure on Q02928
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0008392 arachidonic acid epoxygenase activity
GO:0016491 oxidoreductase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0018685 alkane 1-monooxygenase activity
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0050051 leukotriene-B4 20-monooxygenase activity

Biological Process:
GO:0001676 long-chain fatty acid metabolic process
GO:0003091 renal water homeostasis
GO:0003095 pressure natriuresis
GO:0006631 fatty acid metabolic process
GO:0006691 leukotriene metabolic process
GO:0019216 regulation of lipid metabolic process
GO:0019369 arachidonic acid metabolic process
GO:0019373 epoxygenase P450 pathway
GO:0032305 positive regulation of icosanoid secretion
GO:0036101 leukotriene B4 catabolic process
GO:0055078 sodium ion homeostasis
GO:0055114 oxidation-reduction process
GO:0097267 omega-hydroxylase P450 pathway

Cellular Component:
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0031090 organelle membrane
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  L04751 - Human cytochrome p-450 4A (CYP4A) mRNA, complete cds.
D13705 - Homo sapiens mRNA for fatty acids omega-hydroxylase (cytochrome P-450HKV), complete cds.
JD556626 - Sequence 537650 from Patent EP1572962.
JD556627 - Sequence 537651 from Patent EP1572962.
JD323249 - Sequence 304273 from Patent EP1572962.
S67580 - CYP4A11=fatty acid omega-hydroxylase [human, kidney, mRNA, 2470 nt].
S67581 - CYP4A11=fatty acid omega-hydroxylase [human, kidney, mRNA Mutant, 2469 nt].
JD308211 - Sequence 289235 from Patent EP1572962.
JD037354 - Sequence 18378 from Patent EP1572962.
JD422784 - Sequence 403808 from Patent EP1572962.
JD120408 - Sequence 101432 from Patent EP1572962.
JD414682 - Sequence 395706 from Patent EP1572962.
JD414681 - Sequence 395705 from Patent EP1572962.
D26481 - Homo sapiens mRNA for fatty acids omega-hydroxylase, complete cds.
JD320776 - Sequence 301800 from Patent EP1572962.
JD405947 - Sequence 386971 from Patent EP1572962.
JD478177 - Sequence 459201 from Patent EP1572962.
JD429492 - Sequence 410516 from Patent EP1572962.
JD477648 - Sequence 458672 from Patent EP1572962.
JD304403 - Sequence 285427 from Patent EP1572962.
JD226207 - Sequence 207231 from Patent EP1572962.
JD559265 - Sequence 540289 from Patent EP1572962.
JD523567 - Sequence 504591 from Patent EP1572962.
JD198541 - Sequence 179565 from Patent EP1572962.
JD310822 - Sequence 291846 from Patent EP1572962.
JD163810 - Sequence 144834 from Patent EP1572962.
JD161961 - Sequence 142985 from Patent EP1572962.
JD547230 - Sequence 528254 from Patent EP1572962.
JD099773 - Sequence 80797 from Patent EP1572962.
JD339120 - Sequence 320144 from Patent EP1572962.
JD063627 - Sequence 44651 from Patent EP1572962.
BC022851 - Homo sapiens cytochrome P450, family 4, subfamily A, polypeptide 11, mRNA (cDNA clone IMAGE:4072062).
BC041158 - Homo sapiens cytochrome P450, family 4, subfamily A, polypeptide 11, mRNA (cDNA clone MGC:48730 IMAGE:5183289), complete cds.
AK298267 - Homo sapiens cDNA FLJ60759 complete cds, highly similar to Cytochrome P450 4A11 precursor (EC 1.14.15.3).
AK298413 - Homo sapiens cDNA FLJ57552 complete cds, highly similar to Cytochrome P450 4A11 precursor (EC 1.14.15.3).
CU692736 - Synthetic construct Homo sapiens gateway clone IMAGE:100021813 5' read CYP4A11 mRNA.
KJ904447 - Synthetic construct Homo sapiens clone ccsbBroadEn_13841 CYP4A11 gene, encodes complete protein.
JD146735 - Sequence 127759 from Patent EP1572962.
JD493360 - Sequence 474384 from Patent EP1572962.
JD184895 - Sequence 165919 from Patent EP1572962.
JD110478 - Sequence 91502 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_nuclearRsPathway - Nuclear Receptors in Lipid Metabolism and Toxicity

Reactome (by CSHL, EBI, and GO)

Protein Q02928 (Reactome details) participates in the following event(s):

R-HSA-2161814 Arachidonic acid is hydroxylated to 19-HETE by CYP(2)
R-HSA-2161940 Arachidonic acid is hydroxylated to 20-HETE by CYP(3)
R-HSA-76466 CYP4A11 12-hydroxylates DDCX
R-HSA-2161792 20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3
R-HSA-2161745 20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3
R-HSA-211873 CYP4F2, 4F3 20-hydroxylate LTB4
R-HSA-211924 CYP4B1 12-hydroxylates ARA
R-HSA-215526 CYP4F3 20-hydroxylates LTB4
R-HSA-211962 CYP4F11 16-hydroxylates 3OH-PALM
R-HSA-1989781 PPARA activates gene expression
R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
R-HSA-211935 Fatty acids
R-HSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-HSA-211979 Eicosanoids
R-HSA-211958 Miscellaneous substrates
R-HSA-556833 Metabolism of lipids
R-HSA-2142753 Arachidonic acid metabolism
R-HSA-211897 Cytochrome P450 - arranged by substrate type
R-HSA-1430728 Metabolism
R-HSA-8978868 Fatty acid metabolism
R-HSA-211945 Phase I - Functionalization of compounds
R-HSA-211859 Biological oxidations

-  Other Names for This Gene
  Alternate Gene Symbols: CP4AB_HUMAN, CYP4A11 , CYP4A2, ENST00000310638.1, ENST00000310638.2, ENST00000310638.3, ENST00000310638.4, ENST00000310638.5, ENST00000310638.6, ENST00000310638.7, ENST00000310638.8, NR_134994, Q02928, Q06766, Q16865, Q16866, Q5VSP8, Q86SU6, Q8IWY5, uc317ouo.1, uc317ouo.2
UCSC ID: ENST00000310638.9_10
RefSeq Accession: NM_000778.4
Protein: Q02928 (aka CP4AB_HUMAN or CP4Y_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.