ID:DACT1_HUMAN DESCRIPTION: RecName: Full=Dapper homolog 1; Short=hDPR1; AltName: Full=Dapper antagonist of catenin 1; AltName: Full=Hepatocellular carcinoma novel gene 3 protein; FUNCTION: Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome- dependent mechanism; the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB. Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2; the function seems to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway (By similarity). The nuclear form may prevent the formation of LEF1:CTNNB1 complex and recruit HDAC1 to LEF1 at target gene promoters to repress transcription thus antagonizing Wnt signaling. May be involved in positive regulation of fat cell differentiation. During neuronal differentiation may be involved in excitatory synapse organization, and dendrite formation and establishment of spines. SUBUNIT: Can form homodimers and heterodimers with DACT2 or DACT3. Interacts with CSNK1D, PKA catalytic subunit, PKC-type kinase, CSNK2A1, CSNK2B, DVL1, DVL3, VANGL1, VANGL2, CTNND1 and HDAC1 (By similarity). Interacts with DVL2. Interacts with YWHAB; the interaction is enhanced by PKA phosphorylating DACT1 at Ser-237 and Ser-827. Interacts with CTNNB1 and HDAC1. Interacts with GSK3B; the interaction is indicative for an association of DACT1 with the beta-catenin destruction complex. Interacts with GSK3A. INTERACTION: P35222:CTNNB1; NbExp=3; IntAct=EBI-3951744, EBI-491549; O14641:DVL2; NbExp=6; IntAct=EBI-3951744, EBI-740850; P49841:GSK3B; NbExp=3; IntAct=EBI-3951744, EBI-373586; P31946:YWHAB; NbExp=4; IntAct=EBI-3951744, EBI-359815; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell junction, synapse (By similarity). Note=Shuttles between the nucleus and the cytoplasm. Seems to be nuclear in the absence of Wnt signaling and to translocate to the cytoplasm in its presence. DOMAIN: The C-terminal PDZ-binding motif mediates interaction with the PDZ domains of DSH (Dishevelled) family proteins (By similarity). DISEASE: Defects in DACT1 may be a cause of susceptibility to neural tube defects (NTD) [MIM:182940]. NTD are congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components. SIMILARITY: Belongs to the dapper family. SEQUENCE CAUTION: Sequence=AAF65569.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAD61905.1; Type=Erroneous initiation; Note=Translation N-terminally extended; WEB RESOURCE: Name=Dapper antagonist of beta-catenin homolog 1 (Xenopus laevis) (DACT1); Note=Leiden Open Variation Database (LOVD); URL="http://www.lovd.nl/DACT1";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NYF0
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0001085 RNA polymerase II transcription factor binding GO:0005080 protein kinase C binding GO:0005515 protein binding GO:0008013 beta-catenin binding GO:0042826 histone deacetylase binding GO:0051018 protein kinase A binding GO:0070097 delta-catenin binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0007275 multicellular organism development GO:0007399 nervous system development GO:0016055 Wnt signaling pathway GO:0021915 neural tube development GO:0030177 positive regulation of Wnt signaling pathway GO:0030178 negative regulation of Wnt signaling pathway GO:0031647 regulation of protein stability GO:0032091 negative regulation of protein binding GO:0032092 positive regulation of protein binding GO:0045732 positive regulation of protein catabolic process GO:0046329 negative regulation of JNK cascade GO:0048619 embryonic hindgut morphogenesis GO:0060828 regulation of canonical Wnt signaling pathway GO:0090090 negative regulation of canonical Wnt signaling pathway GO:0090263 positive regulation of canonical Wnt signaling pathway GO:1903364 positive regulation of cellular protein catabolic process GO:1904864 negative regulation of beta-catenin-TCF complex assembly GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway GO:2000134 negative regulation of G1/S transition of mitotic cell cycle GO:1900107 regulation of nodal signaling pathway
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
