Human Gene DBN1 (ENST00000393565.6_10) from GENCODE V47lift37
  Description: drebrin 1, transcript variant 7 (from RefSeq NM_001393631.1)
Gencode Transcript: ENST00000393565.6_10
Gencode Gene: ENSG00000113758.14_17
Transcript (Including UTRs)
   Position: hg19 chr5:176,883,611-176,900,635 Size: 17,025 Total Exon Count: 15 Strand: -
Coding Region
   Position: hg19 chr5:176,884,434-176,900,522 Size: 16,089 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:176,883,611-176,900,635)mRNA (may differ from genome)Protein (695 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGeneCardsHGNC
MalacardsMGIPubMedUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: DREB_HUMAN
DESCRIPTION: RecName: Full=Drebrin; AltName: Full=Developmentally-regulated brain protein;
FUNCTION: Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites, respectively.
SUBUNIT: Binds F-actin.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Brain neurons. Also found in the heart, placenta, skeletal muscle, kidney and pancreas.
SIMILARITY: Contains 1 ADF-H domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: DBN1
Diseases sorted by gene-association score: alzheimer disease (4), down syndrome (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 40.90 RPKM in Cells - Cultured fibroblasts
Total median expression: 1086.10 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -41.30113-0.365 Picture PostScript Text
3' UTR -292.00823-0.355 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002108 - Actin-bd_cofilin/tropomyosin

Pfam Domains:
PF00241 - Cofilin/tropomyosin-type actin-binding protein

SCOP Domains:
101447 - Formin homology 2 domain (FH2 domain)
55753 - Actin depolymerizing proteins

ModBase Predicted Comparative 3D Structure on Q16643
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005522 profilin binding
GO:0045296 cadherin binding

Biological Process:
GO:0007015 actin filament organization
GO:0007275 multicellular organism development
GO:0007399 nervous system development
GO:0010643 cell communication by chemical coupling
GO:0010644 cell communication by electrical coupling
GO:0030154 cell differentiation
GO:0032507 maintenance of protein location in cell
GO:0048168 regulation of neuronal synaptic plasticity
GO:0048699 generation of neurons
GO:0050773 regulation of dendrite development
GO:0061351 neural precursor cell proliferation

Cellular Component:
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005921 gap junction
GO:0005938 cell cortex
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0030054 cell junction
GO:0030425 dendrite
GO:0030426 growth cone
GO:0030863 cortical cytoskeleton
GO:0042641 actomyosin
GO:0042995 cell projection


-  Descriptions from all associated GenBank mRNAs
  JD497307 - Sequence 478331 from Patent EP1572962.
JD432730 - Sequence 413754 from Patent EP1572962.
JD210442 - Sequence 191466 from Patent EP1572962.
JD197495 - Sequence 178519 from Patent EP1572962.
JD130778 - Sequence 111802 from Patent EP1572962.
DQ571854 - Homo sapiens piRNA piR-31966, complete sequence.
JD313065 - Sequence 294089 from Patent EP1572962.
D17530 - Homo sapiens mRNA for drebrin E, complete cds.
U00802 - Human drebrin E2 mRNA (DBN1), complete cds.
BC000283 - Homo sapiens drebrin 1, mRNA (cDNA clone MGC:1517 IMAGE:3356428), complete cds.
BC007281 - Homo sapiens drebrin 1, mRNA (cDNA clone MGC:15625 IMAGE:3343626), complete cds.
AK094125 - Homo sapiens cDNA FLJ36806 fis, clone ASTRO1000165, highly similar to Drebrin.
JD493447 - Sequence 474471 from Patent EP1572962.
AK225523 - Homo sapiens mRNA for drebrin 1 isoform a variant, clone: KAT04801.
JD225289 - Sequence 206313 from Patent EP1572962.
JD292253 - Sequence 273277 from Patent EP1572962.
JD550180 - Sequence 531204 from Patent EP1572962.
BC007567 - Homo sapiens drebrin 1, mRNA (cDNA clone MGC:15517 IMAGE:3028196), complete cds.
AL110225 - Homo sapiens mRNA; cDNA DKFZp434D064 (from clone DKFZp434D064); partial cds.
JD483909 - Sequence 464933 from Patent EP1572962.
JD394970 - Sequence 375994 from Patent EP1572962.
JD370548 - Sequence 351572 from Patent EP1572962.
AK295295 - Homo sapiens cDNA FLJ53620 complete cds, highly similar to Drebrin.
JD361989 - Sequence 343013 from Patent EP1572962.
JD241943 - Sequence 222967 from Patent EP1572962.
JD340344 - Sequence 321368 from Patent EP1572962.
KJ896689 - Synthetic construct Homo sapiens clone ccsbBroadEn_06083 DBN1 gene, encodes complete protein.
LC369599 - Homo sapiens DBN1 mRNA for drebrin A, complete cds.
AK314645 - Homo sapiens cDNA, FLJ95489, highly similar to Homo sapiens drebrin 1 (DBN1), transcript variant 1, mRNA.
AB463582 - Synthetic construct DNA, clone: pF1KB8355, Homo sapiens DBN1 gene for drebrin 1, without stop codon, in Flexi system.
AM393436 - Synthetic construct Homo sapiens clone IMAGE:100002514 for hypothetical protein (DBN1 gene).
BC114553 - Homo sapiens drebrin 1, mRNA (cDNA clone IMAGE:40053662), with apparent retained intron.
LF212531 - JP 2014500723-A/20034: Polycomb-Associated Non-Coding RNAs.
MA448108 - JP 2018138019-A/20034: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A8MV58, B2RBG0, D0S117E, DREB_HUMAN, ENST00000393565.1, ENST00000393565.2, ENST00000393565.3, ENST00000393565.4, ENST00000393565.5, NM_001393631, Q16643, Q9UFZ5, uc318vys.1, uc318vys.2
UCSC ID: ENST00000393565.6_10
RefSeq Accession: NM_001363541.2
Protein: Q16643 (aka DREB_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.