Human Gene DCAF11 (ENST00000446197.8_5) from GENCODE V47lift37
  Description: DDB1 and CUL4 associated factor 11, transcript variant 1 (from RefSeq NM_025230.5)
Gencode Transcript: ENST00000446197.8_5
Gencode Gene: ENSG00000100897.18_12
Transcript (Including UTRs)
   Position: hg19 chr14:24,583,986-24,594,451 Size: 10,466 Total Exon Count: 15 Strand: +
Coding Region
   Position: hg19 chr14:24,584,804-24,592,518 Size: 7,715 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:24,583,986-24,594,451)mRNA (may differ from genome)Protein (546 aa)
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MGIOMIMPubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: DCA11_HUMAN
DESCRIPTION: RecName: Full=DDB1- and CUL4-associated factor 11; AltName: Full=WD repeat-containing protein 23;
FUNCTION: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
PATHWAY: Protein modification; protein ubiquitination.
SUBUNIT: Interacts with DDB1 and CUL4A.
INTERACTION: P12504:vif (xeno); NbExp=3; IntAct=EBI-2213388, EBI-779991;
SIMILARITY: Contains 7 WD repeats.
SEQUENCE CAUTION: Sequence=AAG35498.1; Type=Erroneous initiation; Sequence=AAG44727.1; Type=Frameshift; Positions=514, 516, 519, 535; Sequence=BAB15698.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 48.15 RPKM in Liver
Total median expression: 1163.83 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -293.80730-0.402 Picture PostScript Text
3' UTR -702.801933-0.364 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR020472 - G-protein_beta_WD-40_rep
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR017986 - WD40_repeat_dom
IPR017399 - WD_repeat_p23

Pfam Domains:
PF00400 - WD domain, G-beta repeat

SCOP Domains:
50952 - Soluble quinoprotein glucose dehydrogenase
50956 - Thermostable phytase (3-phytase)
50960 - TolB, C-terminal domain
63825 - YWTD domain
63829 - Calcium-dependent phosphotriesterase
69304 - Tricorn protease N-terminal domain
101898 - NHL repeat
50965 - Galactose oxidase, central domain
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
101908 - Putative isomerase YbhE
117289 - Nucleoporin domain
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50974 - Nitrous oxide reductase, N-terminal domain
50978 - WD40 repeat-like
50993 - Peptidase/esterase 'gauge' domain
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
82171 - DPP6 N-terminal domain-like

ModBase Predicted Comparative 3D Structure on Q8TEB1
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsembl WormBase 
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0016567 protein ubiquitination
GO:0043687 post-translational protein modification

Cellular Component:
GO:0005654 nucleoplasm
GO:0080008 Cul4-RING E3 ubiquitin ligase complex


-  Descriptions from all associated GenBank mRNAs
  AB209073 - Homo sapiens mRNA for WD repeat domain 23 isoform 1 variant protein.
AK307849 - Homo sapiens cDNA, FLJ97797.
AK074296 - Homo sapiens cDNA FLJ23716 fis, clone HEP13490, highly similar to Homo sapiens GL014 mRNA.
BC067132 - Homo sapiens WD repeat domain 23, mRNA (cDNA clone MGC:74695 IMAGE:6170335), complete cds.
JD057596 - Sequence 38620 from Patent EP1572962.
JD079160 - Sequence 60184 from Patent EP1572962.
JD217764 - Sequence 198788 from Patent EP1572962.
AF267858 - Homo sapiens GL014 mRNA, complete cds.
AK094478 - Homo sapiens cDNA FLJ37159 fis, clone BRACE2026294, moderately similar to WD repeat protein 23.
BX648224 - Homo sapiens mRNA; cDNA DKFZp779A1629 (from clone DKFZp779A1629).
AK292797 - Homo sapiens cDNA FLJ78744 complete cds, highly similar to Homo sapiens WD repeat domain 23 (WDR23), transcript variant 1, mRNA.
AK296742 - Homo sapiens cDNA FLJ58541 complete cds, highly similar to WD repeat protein 23.
AK057636 - Homo sapiens cDNA FLJ33074 fis, clone TRACH2000250, highly similar to WD repeat protein 23.
BX247970 - human full-length cDNA clone CS0DF009YP11 of Fetal brain of Homo sapiens (human).
JD396616 - Sequence 377640 from Patent EP1572962.
JD360505 - Sequence 341529 from Patent EP1572962.
BX161405 - human full-length cDNA clone CS0DC018YD09 of Neuroblastoma of Homo sapiens (human).
KJ899640 - Synthetic construct Homo sapiens clone ccsbBroadEn_09034 DCAF11 gene, encodes complete protein.
AF130070 - Homo sapiens clone FLB8916 PRO2389 mRNA, complete cds.
BC008858 - Homo sapiens WD repeat domain 23, mRNA (cDNA clone IMAGE:4124120), partial cds.
DQ601630 - Homo sapiens piRNA piR-39696, complete sequence.
AK091857 - Homo sapiens cDNA FLJ34538 fis, clone HLUNG2008479.
AX747226 - Sequence 751 from Patent EP1308459.
AL833831 - Homo sapiens mRNA; cDNA DKFZp434D0516 (from clone DKFZp434D0516).
AK027223 - Homo sapiens cDNA: FLJ23570 fis, clone LNG12158.
JD306883 - Sequence 287907 from Patent EP1572962.
JD020680 - Sequence 1704 from Patent EP1572962.
JD237151 - Sequence 218175 from Patent EP1572962.
JD338289 - Sequence 319313 from Patent EP1572962.
JD259535 - Sequence 240559 from Patent EP1572962.
JD030744 - Sequence 11768 from Patent EP1572962.
JD422648 - Sequence 403672 from Patent EP1572962.
JD236064 - Sequence 217088 from Patent EP1572962.
JD565440 - Sequence 546464 from Patent EP1572962.
JD194461 - Sequence 175485 from Patent EP1572962.
JD415867 - Sequence 396891 from Patent EP1572962.
JD375093 - Sequence 356117 from Patent EP1572962.
DQ577635 - Homo sapiens piRNA piR-45747, complete sequence.
JD456256 - Sequence 437280 from Patent EP1572962.
JD449436 - Sequence 430460 from Patent EP1572962.
JD188963 - Sequence 169987 from Patent EP1572962.
JD146306 - Sequence 127330 from Patent EP1572962.
JD553320 - Sequence 534344 from Patent EP1572962.
JD107199 - Sequence 88223 from Patent EP1572962.
JD239740 - Sequence 220764 from Patent EP1572962.
JD494725 - Sequence 475749 from Patent EP1572962.
JD436440 - Sequence 417464 from Patent EP1572962.
JD190806 - Sequence 171830 from Patent EP1572962.
JD217430 - Sequence 198454 from Patent EP1572962.
JD412891 - Sequence 393915 from Patent EP1572962.
DQ600220 - Homo sapiens piRNA piR-38286, complete sequence.
JD515316 - Sequence 496340 from Patent EP1572962.
JD363643 - Sequence 344667 from Patent EP1572962.
JD518613 - Sequence 499637 from Patent EP1572962.
JD214001 - Sequence 195025 from Patent EP1572962.
JD303301 - Sequence 284325 from Patent EP1572962.
JD100955 - Sequence 81979 from Patent EP1572962.
JD058056 - Sequence 39080 from Patent EP1572962.
JD489262 - Sequence 470286 from Patent EP1572962.
JD499788 - Sequence 480812 from Patent EP1572962.
JD287165 - Sequence 268189 from Patent EP1572962.
JD512771 - Sequence 493795 from Patent EP1572962.
JD379058 - Sequence 360082 from Patent EP1572962.
JD561344 - Sequence 542368 from Patent EP1572962.
JD179690 - Sequence 160714 from Patent EP1572962.
JD419776 - Sequence 400800 from Patent EP1572962.
JD170862 - Sequence 151886 from Patent EP1572962.
JD105699 - Sequence 86723 from Patent EP1572962.
JD159024 - Sequence 140048 from Patent EP1572962.
JD208822 - Sequence 189846 from Patent EP1572962.
JD530025 - Sequence 511049 from Patent EP1572962.
JD215794 - Sequence 196818 from Patent EP1572962.
JD205477 - Sequence 186501 from Patent EP1572962.
JD176943 - Sequence 157967 from Patent EP1572962.
JD068140 - Sequence 49164 from Patent EP1572962.
JD186468 - Sequence 167492 from Patent EP1572962.
JD422203 - Sequence 403227 from Patent EP1572962.
JD229698 - Sequence 210722 from Patent EP1572962.
JD266449 - Sequence 247473 from Patent EP1572962.
JD351215 - Sequence 332239 from Patent EP1572962.
JD237303 - Sequence 218327 from Patent EP1572962.
JD044860 - Sequence 25884 from Patent EP1572962.
JD045184 - Sequence 26208 from Patent EP1572962.
JD268491 - Sequence 249515 from Patent EP1572962.
JD184151 - Sequence 165175 from Patent EP1572962.
JD296356 - Sequence 277380 from Patent EP1572962.
JD281912 - Sequence 262936 from Patent EP1572962.
JD229925 - Sequence 210949 from Patent EP1572962.
JD269346 - Sequence 250370 from Patent EP1572962.
JD189007 - Sequence 170031 from Patent EP1572962.
JD314191 - Sequence 295215 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8TEB1 (Reactome details) participates in the following event(s):

R-HSA-8955245 CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus
R-HSA-8955285 COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex
R-HSA-8952639 NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex
R-HSA-8956045 COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex
R-HSA-8952638 AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex
R-HSA-8951664 Neddylation
R-HSA-597592 Post-translational protein modification
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: B3KQ83, D3DS56, DCA11_HUMAN, ENST00000446197.1, ENST00000446197.2, ENST00000446197.3, ENST00000446197.4, ENST00000446197.5, ENST00000446197.6, ENST00000446197.7, GL014, NM_025230, PRO2389, Q5D039, Q86U00, Q86U39, Q8NDN2, Q8TEB1, Q9H2J0, Q9H3A3, Q9H5C9, uc320nxh.1, uc320nxh.2, WDR23
UCSC ID: ENST00000446197.8_5
RefSeq Accession: NM_025230.5
Protein: Q8TEB1 (aka DCA11_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.