Human Gene DCN (ENST00000052754.10_7) from GENCODE V47lift37

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Description: decorin, transcript variant A2 (from RefSeq NM_133503.4)
Gencode Transcript: ENST00000052754.10_7
Gencode Gene: ENSG00000011465.18_12
Transcript (Including UTRs)
Position: hg19 chr12:91,534,261-91,576,594 Size: 42,334 Total Exon Count: 8 Strand: -
Coding Region
Position: hg19 chr12:91,539,835-91,572,329 Size: 32,495 Coding Exon Count: 7

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	GeneReviews	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr12:91,534,261-91,576,594)			mRNA (may differ from genome)		Protein (359 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: DCN Diseases sorted by gene-association score: corneal dystrophy, congenital stromal* (1377), stromal dystrophy (24), interstitial keratitis (22), localized scleroderma (19), dupuytren contracture (13), neonatal marfan syndrome (13), eosinophilic granuloma (12), cornea plana (12), corneal dystrophy (11), pseudoachondroplasia (10), marfan syndrome (9), renal artery atheroma (9), peyronie's disease (8), gingival overgrowth (8), primary hypertrophic osteoarthropathy (8), crouzon syndrome (7), multiple epiphyseal dysplasia (6), achondrogenesis ib (6), odontogenic myxoma (5), tendinosis (4), nephrogenic systemic fibrosis (4), osseous heteroplasia, progressive (3) * = Manually curated disease association

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D013749 Tetrachlorodibenzodioxin C006780 bisphenol A D000082 Acetaminophen D016604 Aflatoxin B1 D001564 Benzo(a)pyrene D004041 Dietary Fats D004997 Ethinyl Estradiol D010634 Phenobarbital D013629 Tamoxifen D014212 Tretinoin D014635 Valproic Acid C049325 1,2-dithiol-3-thione D015056 1-Methyl-3-isobutylxanthine C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl C016403 2,4-dinitrotoluene C011269 2,5-hexanedione C049584 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine C006593 2-anthramine C019499 2-nitrofluorene C023035 3,4,5,3',4'-pentachlorobiphenyl C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone C027576 4-hydroxy-2-nonenal D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D015127 9,10-Dimethyl-1,2-benzanthracene D000643 Ammonium Chloride D002117 Calcitriol D002251 Carbon Tetrachloride D002737 Chloroprene D002794 Choline D002945 Cisplatin D003035 Cobalt D003474 Curcumin D003513 Cycloheximide D003520 Cyclophosphamide D003561 Cytarabine D003907 Dexamethasone D003993 Dibutyl Phthalate D004052 Diethylnitrosamine D004054 Diethylstilbestrol D004128 Dimethylnitrosamine D004147 Dioxins D004237 Diuron D004317 Doxorubicin C013525 ENNG D005492 Folic Acid D019469 Indinavir D007529 Isoflavones D007545 Isoproterenol D019259 Lamivudine D016912 Levonorgestrel D001556 Lindane D019808 Losartan D008558 Melphalan D008627 Mercuric Chloride D008715 Methionine D008769 Methylnitronitrosoguanidine D015735 Mifepristone C002741 N-nitrosomorpholine D010126 Ozone D019258 Saquinavir C041711 St. Thomas' Hospital cardioplegic solution D013467 Sulindac D013852 Thiotepa D014028 Tobacco Smoke Pollution D014241 Trichloroethylene D014810 Vitamin E D015215 Zidovudine C109238 acyline C044887 beta-methylcholine C002791 bismuth tripotassium dicitrate C010063 carbonyl sulfide C018021 cobaltous chloride C000873 methylprednisolone acetate C017096 n-butoxyethanol C076994 perfluorooctane sulfonic acid C059514 resveratrol C009166 retinol acetate C089730 rosiglitazone C010327 salinomycin C010792 testosterone undecanoate C012589 trichostatin A C057693 troglitazone C002802 tungsten carbide C025643 vinclozolin

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 388.95 RPKM in Ovary Total median expression: 5935.69 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-36.00	196	-0.184	Picture	PostScript	Text
3' UTR	-1367.70	5574	-0.245	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001611 - Leu-rich_rpt
IPR003591 - Leu-rich_rpt_typical-subtyp
IPR000372 - LRR-contain_N
IPR016352 - SLRP_I_decor/aspor/byglycan

Pfam Domains:
PF01462 - Leucine rich repeat N-terminal domain
PF13306 - BspA type Leucine rich repeat region (6 copies)
PF13855 - Leucine rich repeat

SCOP Domains:
52047 - RNI-like
52058 - L domain-like
52075 - Outer arm dynein light chain 1

ModBase Predicted Comparative 3D Structure on Q6FH10


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005518 collagen binding GO:0005539 glycosaminoglycan binding GO:0047485 protein N-terminus binding GO:0050840 extracellular matrix binding Biological Process: GO:0001822 kidney development GO:0001890 placenta development GO:0007519 skeletal muscle tissue development GO:0007568 aging GO:0009612 response to mechanical stimulus GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan GO:0032496 response to lipopolysaccharide GO:0042060 wound healing Cellular Component: GO:0005576 extracellular region GO:0005589 collagen type VI trimer

Descriptions from all associated GenBank mRNAs


	KJ891032 - Synthetic construct Homo sapiens clone ccsbBroadEn_00426 DCN gene, encodes complete protein. LF384686 - JP 2014500723-A/192189: Polycomb-Associated Non-Coding RNAs. BX571756 - Homo sapiens mRNA; cDNA DKFZp686J19238 (from clone DKFZp686J19238). JD379286 - Sequence 360310 from Patent EP1572962. LF323599 - JP 2014500723-A/131102: Polycomb-Associated Non-Coding RNAs. JD148611 - Sequence 129635 from Patent EP1572962. AK291309 - Homo sapiens cDNA FLJ75936 complete cds, highly similar to Homo sapiens decorin (DCN), transcript variant A1, mRNA. LF323598 - JP 2014500723-A/131101: Polycomb-Associated Non-Coding RNAs. BC005322 - Homo sapiens decorin, mRNA (cDNA clone MGC:12406 IMAGE:3934022), complete cds. JD550172 - Sequence 531196 from Patent EP1572962. LF323597 - JP 2014500723-A/131100: Polycomb-Associated Non-Coding RNAs. M14219 - Human chondroitin/dermatan sulfate proteoglycan (PG40) core protein mRNA, complete cds. LF323596 - JP 2014500723-A/131099: Polycomb-Associated Non-Coding RNAs. AF138300 - Homo sapiens decorin variant A mRNA, complete cds. AF138301 - Homo sapiens decorin B mRNA, complete cds, alternatively spliced. AF138302 - Homo sapiens decorin variant C mRNA, complete cds. AF138303 - Homo sapiens decorin D mRNA, complete cds, alternatively spliced. CR541946 - Homo sapiens full open reading frame cDNA clone RZPDo834D1134D for gene DCN, decorin; complete cds, incl. stopcodon. BT019800 - Homo sapiens decorin mRNA, complete cds. DQ892556 - Synthetic construct clone IMAGE:100005186; FLH187471.01X; RZPDo839H0872D decorin (DCN) gene, encodes complete protein. DQ895769 - Synthetic construct Homo sapiens clone IMAGE:100010229; FLH187467.01L; RZPDo839H0862D decorin (DCN) gene, encodes complete protein. CR407676 - Homo sapiens full open reading frame cDNA clone RZPDo834C053D for gene DCN, decorin complete cds, without stopcodon. KU178017 - Homo sapiens decorin isoform 1 (DCN) mRNA, partial cds. KU178018 - Homo sapiens decorin isoform 2 (DCN) mRNA, partial cds, alternatively spliced. KU178019 - Homo sapiens decorin isoform 3 (DCN) mRNA, complete cds, alternatively spliced. KU178020 - Homo sapiens decorin isoform 4 (DCN) mRNA, complete cds, alternatively spliced. AB463564 - Synthetic construct DNA, clone: pF1KB6509, Homo sapiens DCN gene for decorin, without stop codon, in Flexi system. CU675109 - Synthetic construct Homo sapiens gateway clone IMAGE:100017098 5' read DCN mRNA. JD263067 - Sequence 244091 from Patent EP1572962. JD508954 - Sequence 489978 from Patent EP1572962. LF323595 - JP 2014500723-A/131098: Polycomb-Associated Non-Coding RNAs. AF138304 - Homo sapiens decorin variant E mRNA, complete cds. LF323594 - JP 2014500723-A/131097: Polycomb-Associated Non-Coding RNAs. LF323593 - JP 2014500723-A/131096: Polycomb-Associated Non-Coding RNAs. LF323592 - JP 2014500723-A/131095: Polycomb-Associated Non-Coding RNAs. LF323591 - JP 2014500723-A/131094: Polycomb-Associated Non-Coding RNAs. LF323590 - JP 2014500723-A/131093: Polycomb-Associated Non-Coding RNAs. LF323589 - JP 2014500723-A/131092: Polycomb-Associated Non-Coding RNAs. AL355731 - Homo sapiens EST from clone 130486, 5' end. LF323586 - JP 2014500723-A/131089: Polycomb-Associated Non-Coding RNAs. JD023146 - Sequence 4170 from Patent EP1572962. JD034857 - Sequence 15881 from Patent EP1572962. JD249379 - Sequence 230403 from Patent EP1572962. LF323585 - JP 2014500723-A/131088: Polycomb-Associated Non-Coding RNAs. MA620263 - JP 2018138019-A/192189: Polycomb-Associated Non-Coding RNAs. MA559176 - JP 2018138019-A/131102: Polycomb-Associated Non-Coding RNAs. MA559175 - JP 2018138019-A/131101: Polycomb-Associated Non-Coding RNAs. MA559174 - JP 2018138019-A/131100: Polycomb-Associated Non-Coding RNAs. MA559173 - JP 2018138019-A/131099: Polycomb-Associated Non-Coding RNAs. MA559172 - JP 2018138019-A/131098: Polycomb-Associated Non-Coding RNAs. MA559171 - JP 2018138019-A/131097: Polycomb-Associated Non-Coding RNAs. MA559170 - JP 2018138019-A/131096: Polycomb-Associated Non-Coding RNAs. MA559169 - JP 2018138019-A/131095: Polycomb-Associated Non-Coding RNAs. MA559168 - JP 2018138019-A/131094: Polycomb-Associated Non-Coding RNAs. MA559167 - JP 2018138019-A/131093: Polycomb-Associated Non-Coding RNAs. MA559166 - JP 2018138019-A/131092: Polycomb-Associated Non-Coding RNAs. MA559163 - JP 2018138019-A/131089: Polycomb-Associated Non-Coding RNAs. MA559162 - JP 2018138019-A/131088: Polycomb-Associated Non-Coding RNAs.

Biochemical and Signaling Pathways


	BioCarta from NCI Cancer Genome Anatomy Project h_slrpPathway - Small Leucine-rich Proteoglycan (SLRP) molecules

Other Names for This Gene


	Alternate Gene Symbols: DCN , DKFZp686J19238 , ENST00000052754.1, ENST00000052754.2, ENST00000052754.3, ENST00000052754.4, ENST00000052754.5, ENST00000052754.6, ENST00000052754.7, ENST00000052754.8, ENST00000052754.9, hCG_24110 , NM_133503, Q6FH10, Q6FH10_HUMAN, uc317bzu.1, uc317bzu.2 UCSC ID: ENST00000052754.10_7 RefSeq Accession: NM_001920.5 Protein: Q6FH10

GeneReviews for This Gene


	GeneReviews article(s) related to gene DCN: csc-dys (Congenital Stromal Corneal Dystrophy)

Gene Model Information


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Methods, Credits, and Use Restrictions


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