ID:DCP1A_HUMAN DESCRIPTION: RecName: Full=mRNA-decapping enzyme 1A; EC=3.-.-.-; AltName: Full=Smad4-interacting transcriptional co-activator; AltName: Full=Transcription factor SMIF; FUNCTION: Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1. SUBUNIT: Forms a complex with EDC3, DCP2, DDX6 and EDC4/HEDLS, within this complex directly interacts with EDC3. Binds DCP1B, UPF1 and SMAD4. Part of a cytoplasmic complex containing proteins involved in mRNA decay, including XRN1 and LSM1. Interacts with PNRC2. Interacts with DDX17 in an RNA-independent manner. Interacts with ZC3HAV1. INTERACTION: Self; NbExp=4; IntAct=EBI-374238, EBI-374238; Q8IU60:DCP2; NbExp=6; IntAct=EBI-374238, EBI-521577; P26196:DDX6; NbExp=4; IntAct=EBI-374238, EBI-351257; Q92900:UPF1; NbExp=13; IntAct=EBI-374238, EBI-373471; P26651:ZFP36; NbExp=2; IntAct=EBI-374238, EBI-374248; SUBCELLULAR LOCATION: Cytoplasm, P-body. Nucleus. Note=Co- localizes with NANOS3 in the processing bodies (By similarity). Predominantly cytoplasmic, in processing bodies (PB). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4. TISSUE SPECIFICITY: Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas. SIMILARITY: Belongs to the DCP1 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NPI6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
