Human Gene DCTN5 (ENST00000300087.7_4) from GENCODE V47lift37
  Description: dynactin subunit 5, transcript variant 3 (from RefSeq NR_037573.2)
Gencode Transcript: ENST00000300087.7_4
Gencode Gene: ENSG00000166847.10_8
Transcript (Including UTRs)
   Position: hg19 chr16:23,652,787-23,688,793 Size: 36,007 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr16:23,652,864-23,678,465 Size: 25,602 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:23,652,787-23,688,793)mRNA (may differ from genome)Protein (182 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: DCTN5_HUMAN
DESCRIPTION: RecName: Full=Dynactin subunit 5; AltName: Full=Dynactin subunit p25;
SUBUNIT: Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10 (By similarity).
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity).
SIMILARITY: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: DCTN5
Diseases sorted by gene-association score: polycystic kidney disease 4, with or without hepatic disease (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 24.05 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 498.82 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -20.2077-0.262 Picture PostScript Text
3' UTR -3378.4010328-0.327 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001451 - Hexapep_transf
IPR011004 - Trimer_LpxA-like

Pfam Domains:
PF14602 - Hexapeptide repeat of succinyl-transferase

SCOP Domains:
51126 - Pectin lyase-like
51161 - Trimeric LpxA-like enzymes
53448 - Nucleotide-diphospho-sugar transferases

ModBase Predicted Comparative 3D Structure on Q9BTE1
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0003281 ventricular septum development
GO:0006888 ER to Golgi vesicle-mediated transport
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0035904 aorta development
GO:0060976 coronary vasculature development

Cellular Component:
GO:0000775 chromosome, centromeric region
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0031965 nuclear membrane


-  Descriptions from all associated GenBank mRNAs
  LF384295 - JP 2014500723-A/191798: Polycomb-Associated Non-Coding RNAs.
AK292843 - Homo sapiens cDNA FLJ78341 complete cds, highly similar to Homo sapiens dynactin 4, mRNA.
AK299631 - Homo sapiens cDNA FLJ57579 complete cds, highly similar to Dynactin subunit 5.
BC004191 - Homo sapiens dynactin 5 (p25), mRNA (cDNA clone MGC:3248 IMAGE:3505855), complete cds.
AK027387 - Homo sapiens cDNA FLJ14481 fis, clone MAMMA1002351, highly similar to Mus musculus dynactin subunit p25 (p25) mRNA.
JD211193 - Sequence 192217 from Patent EP1572962.
JF432443 - Synthetic construct Homo sapiens clone IMAGE:100073652 dynactin 5 (p25) (DCTN5) gene, encodes complete protein.
KJ895000 - Synthetic construct Homo sapiens clone ccsbBroadEn_04394 DCTN5 gene, encodes complete protein.
LF369782 - JP 2014500723-A/177285: Polycomb-Associated Non-Coding RNAs.
AK126469 - Homo sapiens cDNA FLJ44505 fis, clone UTERU3001542.
LF369783 - JP 2014500723-A/177286: Polycomb-Associated Non-Coding RNAs.
JD417419 - Sequence 398443 from Patent EP1572962.
JD504267 - Sequence 485291 from Patent EP1572962.
JD314830 - Sequence 295854 from Patent EP1572962.
JD225456 - Sequence 206480 from Patent EP1572962.
JD270465 - Sequence 251489 from Patent EP1572962.
JD481799 - Sequence 462823 from Patent EP1572962.
JD515682 - Sequence 496706 from Patent EP1572962.
JD233516 - Sequence 214540 from Patent EP1572962.
JD119989 - Sequence 101013 from Patent EP1572962.
JD502500 - Sequence 483524 from Patent EP1572962.
JD103993 - Sequence 85017 from Patent EP1572962.
JD555592 - Sequence 536616 from Patent EP1572962.
JD499216 - Sequence 480240 from Patent EP1572962.
JD093469 - Sequence 74493 from Patent EP1572962.
JD452759 - Sequence 433783 from Patent EP1572962.
JD051959 - Sequence 32983 from Patent EP1572962.
JD296635 - Sequence 277659 from Patent EP1572962.
JD245231 - Sequence 226255 from Patent EP1572962.
JD358642 - Sequence 339666 from Patent EP1572962.
JD518460 - Sequence 499484 from Patent EP1572962.
JD485189 - Sequence 466213 from Patent EP1572962.
JD545797 - Sequence 526821 from Patent EP1572962.
JD301897 - Sequence 282921 from Patent EP1572962.
JD340612 - Sequence 321636 from Patent EP1572962.
JD214449 - Sequence 195473 from Patent EP1572962.
JD063590 - Sequence 44614 from Patent EP1572962.
JD319897 - Sequence 300921 from Patent EP1572962.
JD298976 - Sequence 280000 from Patent EP1572962.
JD292903 - Sequence 273927 from Patent EP1572962.
JD189240 - Sequence 170264 from Patent EP1572962.
JD436581 - Sequence 417605 from Patent EP1572962.
JD496223 - Sequence 477247 from Patent EP1572962.
LF369784 - JP 2014500723-A/177287: Polycomb-Associated Non-Coding RNAs.
JD506499 - Sequence 487523 from Patent EP1572962.
JD252456 - Sequence 233480 from Patent EP1572962.
JD250777 - Sequence 231801 from Patent EP1572962.
JD343424 - Sequence 324448 from Patent EP1572962.
JD091886 - Sequence 72910 from Patent EP1572962.
JD082146 - Sequence 63170 from Patent EP1572962.
JD127326 - Sequence 108350 from Patent EP1572962.
DQ585866 - Homo sapiens piRNA piR-52978, complete sequence.
JD199076 - Sequence 180100 from Patent EP1572962.
JD382295 - Sequence 363319 from Patent EP1572962.
JD313849 - Sequence 294873 from Patent EP1572962.
DQ596523 - Homo sapiens piRNA piR-34589, complete sequence.
JD222428 - Sequence 203452 from Patent EP1572962.
JD170492 - Sequence 151516 from Patent EP1572962.
JD107283 - Sequence 88307 from Patent EP1572962.
JD300069 - Sequence 281093 from Patent EP1572962.
JD393856 - Sequence 374880 from Patent EP1572962.
DQ577462 - Homo sapiens piRNA piR-45574, complete sequence.
JD545219 - Sequence 526243 from Patent EP1572962.
AK022200 - Homo sapiens cDNA FLJ12138 fis, clone MAMMA1000331.
JD026143 - Sequence 7167 from Patent EP1572962.
JD031146 - Sequence 12170 from Patent EP1572962.
JD031490 - Sequence 12514 from Patent EP1572962.
LF369785 - JP 2014500723-A/177288: Polycomb-Associated Non-Coding RNAs.
LF369786 - JP 2014500723-A/177289: Polycomb-Associated Non-Coding RNAs.
JD312173 - Sequence 293197 from Patent EP1572962.
JD312174 - Sequence 293198 from Patent EP1572962.
JD312175 - Sequence 293199 from Patent EP1572962.
JD425257 - Sequence 406281 from Patent EP1572962.
JD454074 - Sequence 435098 from Patent EP1572962.
JD375975 - Sequence 356999 from Patent EP1572962.
AK055300 - Homo sapiens cDNA FLJ30738 fis, clone FEBRA2000297.
DQ599614 - Homo sapiens piRNA piR-37680, complete sequence.
JD498434 - Sequence 479458 from Patent EP1572962.
DQ597839 - Homo sapiens piRNA piR-35905, complete sequence.
DQ599919 - Homo sapiens piRNA piR-37985, complete sequence.
DQ596200 - Homo sapiens piRNA piR-34266, complete sequence.
JD538367 - Sequence 519391 from Patent EP1572962.
JD144680 - Sequence 125704 from Patent EP1572962.
JD543277 - Sequence 524301 from Patent EP1572962.
JD478591 - Sequence 459615 from Patent EP1572962.
JD463837 - Sequence 444861 from Patent EP1572962.
JD148326 - Sequence 129350 from Patent EP1572962.
JD249883 - Sequence 230907 from Patent EP1572962.
JD354356 - Sequence 335380 from Patent EP1572962.
JD096095 - Sequence 77119 from Patent EP1572962.
BC031322 - Homo sapiens cDNA clone IMAGE:5284820.
DQ578089 - Homo sapiens piRNA piR-46201, complete sequence.
MA619872 - JP 2018138019-A/191798: Polycomb-Associated Non-Coding RNAs.
MA605359 - JP 2018138019-A/177285: Polycomb-Associated Non-Coding RNAs.
MA605360 - JP 2018138019-A/177286: Polycomb-Associated Non-Coding RNAs.
MA605361 - JP 2018138019-A/177287: Polycomb-Associated Non-Coding RNAs.
MA605362 - JP 2018138019-A/177288: Polycomb-Associated Non-Coding RNAs.
MA605363 - JP 2018138019-A/177289: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9BTE1 (Reactome details) participates in the following event(s):

R-HSA-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin
R-HSA-6809006 Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex
R-HSA-8849350 RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex
R-HSA-2132295 MHC class II antigen presentation
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-HSA-1280218 Adaptive Immune System
R-HSA-199977 ER to Golgi Anterograde Transport
R-HSA-8856688 Golgi-to-ER retrograde transport
R-HSA-168256 Immune System
R-HSA-199991 Membrane Trafficking
R-HSA-948021 Transport to the Golgi and subsequent modification
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-5653656 Vesicle-mediated transport
R-HSA-446203 Asparagine N-linked glycosylation
R-HSA-597592 Post-translational protein modification
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: A8K9X8, DCTN5 , DCTN5_HUMAN, ENST00000300087.1, ENST00000300087.2, ENST00000300087.3, ENST00000300087.4, ENST00000300087.5, ENST00000300087.6, H3BN51, H3BQA4, NR_037573, Q9BTE1, uc317mnl.1, uc317mnl.2
UCSC ID: ENST00000300087.7_4
RefSeq Accession: NM_032486.4
Protein: Q9BTE1 (aka DCTN5_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.