Human Gene DDX10 (ENST00000322536.8_7) from GENCODE V47lift37
  Description: DEAD-box helicase 10 (from RefSeq NM_004398.4)
Gencode Transcript: ENST00000322536.8_7
Gencode Gene: ENSG00000178105.12_13
Transcript (Including UTRs)
   Position: hg19 chr11:108,535,796-108,811,654 Size: 275,859 Total Exon Count: 18 Strand: +
Coding Region
   Position: hg19 chr11:108,535,881-108,811,150 Size: 275,270 Coding Exon Count: 18 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:108,535,796-108,811,654)mRNA (may differ from genome)Protein (875 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: DDX10_HUMAN
DESCRIPTION: RecName: Full=Probable ATP-dependent RNA helicase DDX10; EC=3.6.4.13; AltName: Full=DEAD box protein 10;
FUNCTION: Putative ATP-dependent RNA helicase.
CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
TISSUE SPECIFICITY: High in testis but widely expressed.
DOMAIN: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
SIMILARITY: Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily.
SIMILARITY: Contains 1 helicase ATP-binding domain.
SIMILARITY: Contains 1 helicase C-terminal domain.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/DDX10.html";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: DDX10
Diseases sorted by gene-association score: myelodysplastic syndrome (3), leukemia, acute myeloid (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.02 RPKM in Testis
Total median expression: 125.96 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -19.6085-0.231 Picture PostScript Text
3' UTR -115.20504-0.229 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011545 - DNA/RNA_helicase_DEAD/DEAH_N
IPR025313 - DUF4217
IPR014001 - Helicase_ATP-bd
IPR001650 - Helicase_C
IPR000629 - RNA-helicase_DEAD-box_CS
IPR014014 - RNA_helicase_DEAD_Q_motif

Pfam Domains:
PF00270 - DEAD/DEAH box helicase
PF00271 - Helicase conserved C-terminal domain
PF04851 - Type III restriction enzyme, res subunit
PF13959 - Domain of unknown function (DUF4217)

SCOP Domains:
47113 - Histone-fold
52540 - P-loop containing nucleoside triphosphate hydrolases

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2PL3 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q13206
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene DetailsGene Details Gene Details Gene Details
Gene SorterGene Sorter Gene Sorter Gene Sorter
 RGDEnsembl  SGD
     Protein Sequence
     Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004004 ATP-dependent RNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity

Biological Process:
GO:0010501 RNA secondary structure unwinding
GO:0097065 anterior head development

Cellular Component:
GO:0005730 nucleolus
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AK296752 - Homo sapiens cDNA FLJ51228 complete cds, highly similar to Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-).
BC091521 - Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 10, mRNA (cDNA clone MGC:111510 IMAGE:30388370), complete cds.
AB040537 - Homo sapiens DDX10 mRNA for RNA helicase, complete cds.
LF384549 - JP 2014500723-A/192052: Polycomb-Associated Non-Coding RNAs.
U28042 - Human DEAD box RNA helicase-like protein mRNA, complete cds.
AK315216 - Homo sapiens cDNA, FLJ96210, Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 (DDX10),mRNA.
BC093654 - Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 10, mRNA (cDNA clone MGC:120689 IMAGE:7939499), complete cds.
BC093656 - Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 10, mRNA (cDNA clone MGC:120691 IMAGE:7939501), complete cds.
AB209884 - Homo sapiens mRNA for DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 variant protein.
BC064921 - Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 10, mRNA (cDNA clone IMAGE:6141012), partial cds.
BC049217 - Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 10, mRNA (cDNA clone IMAGE:5500425), partial cds.
MA620126 - JP 2018138019-A/192052: Polycomb-Associated Non-Coding RNAs.
LF377020 - JP 2014500723-A/184523: Polycomb-Associated Non-Coding RNAs.
AB001343 - Homo sapiens mRNA for DDX10-NUP98 fusion protein type 2, partial cds.
AB000267 - Homo sapiens mRNA for NUP98-DDX10 fusion protein type 1, partial cds.
LF377016 - JP 2014500723-A/184519: Polycomb-Associated Non-Coding RNAs.
LF377011 - JP 2014500723-A/184514: Polycomb-Associated Non-Coding RNAs.
JD353481 - Sequence 334505 from Patent EP1572962.
JD268151 - Sequence 249175 from Patent EP1572962.
LF377009 - JP 2014500723-A/184512: Polycomb-Associated Non-Coding RNAs.
LF377008 - JP 2014500723-A/184511: Polycomb-Associated Non-Coding RNAs.
MA612597 - JP 2018138019-A/184523: Polycomb-Associated Non-Coding RNAs.
MA612593 - JP 2018138019-A/184519: Polycomb-Associated Non-Coding RNAs.
MA612588 - JP 2018138019-A/184514: Polycomb-Associated Non-Coding RNAs.
MA612586 - JP 2018138019-A/184512: Polycomb-Associated Non-Coding RNAs.
MA612585 - JP 2018138019-A/184511: Polycomb-Associated Non-Coding RNAs.
LF377002 - JP 2014500723-A/184505: Polycomb-Associated Non-Coding RNAs.
LF377000 - JP 2014500723-A/184503: Polycomb-Associated Non-Coding RNAs.
LF376999 - JP 2014500723-A/184502: Polycomb-Associated Non-Coding RNAs.
LF376998 - JP 2014500723-A/184501: Polycomb-Associated Non-Coding RNAs.
LF376993 - JP 2014500723-A/184496: Polycomb-Associated Non-Coding RNAs.
MA612579 - JP 2018138019-A/184505: Polycomb-Associated Non-Coding RNAs.
MA612577 - JP 2018138019-A/184503: Polycomb-Associated Non-Coding RNAs.
MA612576 - JP 2018138019-A/184502: Polycomb-Associated Non-Coding RNAs.
MA612575 - JP 2018138019-A/184501: Polycomb-Associated Non-Coding RNAs.
MA612570 - JP 2018138019-A/184496: Polycomb-Associated Non-Coding RNAs.
JD326606 - Sequence 307630 from Patent EP1572962.
JD164146 - Sequence 145170 from Patent EP1572962.
JD351973 - Sequence 332997 from Patent EP1572962.
JD220454 - Sequence 201478 from Patent EP1572962.
JD126277 - Sequence 107301 from Patent EP1572962.
JD240361 - Sequence 221385 from Patent EP1572962.
JD290915 - Sequence 271939 from Patent EP1572962.
JD553932 - Sequence 534956 from Patent EP1572962.
JD173916 - Sequence 154940 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RCQ3, DDX10_HUMAN, ENST00000322536.1, ENST00000322536.2, ENST00000322536.3, ENST00000322536.4, ENST00000322536.5, ENST00000322536.6, ENST00000322536.7, NM_004398, Q13206, Q5BJD8, uc317rhk.1, uc317rhk.2
UCSC ID: ENST00000322536.8_7
RefSeq Accession: NM_004398.4
Protein: Q13206 (aka DDX10_HUMAN or DD10_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.