Human Gene DDX19A (ENST00000302243.12_4) from GENCODE V47lift37
  Description: DEAD-box helicase 19A, transcript variant 6 (from RefSeq NR_135296.2)
Gencode Transcript: ENST00000302243.12_4
Gencode Gene: ENSG00000168872.17_10
Transcript (Including UTRs)
   Position: hg19 chr16:70,380,806-70,407,286 Size: 26,481 Total Exon Count: 12 Strand: +
Coding Region
   Position: hg19 chr16:70,380,895-70,405,889 Size: 24,995 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:70,380,806-70,407,286)mRNA (may differ from genome)Protein (478 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: DD19A_HUMAN
DESCRIPTION: RecName: Full=ATP-dependent RNA helicase DDX19A; EC=3.6.4.13; AltName: Full=DDX19-like protein; AltName: Full=DEAD box protein 19A;
FUNCTION: ATP-dependent RNA helicase involved in mRNA export from the nucleus (By similarity).
CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Nuclear pore complex cytoplasmic fibrils.
SIMILARITY: Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.
SIMILARITY: Contains 1 helicase ATP-binding domain.
SIMILARITY: Contains 1 helicase C-terminal domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 16.89 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 611.00 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -35.2089-0.396 Picture PostScript Text
3' UTR -455.901397-0.326 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011545 - DNA/RNA_helicase_DEAD/DEAH_N
IPR014001 - Helicase_ATP-bd
IPR001650 - Helicase_C
IPR014014 - RNA_helicase_DEAD_Q_motif

Pfam Domains:
PF00270 - DEAD/DEAH box helicase
PF00271 - Helicase conserved C-terminal domain

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on Q9NUU7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 RGD  WormBaseSGD
    Protein SequenceProtein Sequence
    AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003674 molecular_function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004004 ATP-dependent RNA helicase activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity

Biological Process:
GO:0008150 biological_process
GO:0008380 RNA splicing
GO:0010468 regulation of gene expression
GO:0010501 RNA secondary structure unwinding
GO:0015031 protein transport
GO:0051028 mRNA transport

Cellular Component:
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0031965 nuclear membrane
GO:0071013 catalytic step 2 spliceosome


-  Descriptions from all associated GenBank mRNAs
  AF183422 - Homo sapiens RNA helicase mRNA, complete cds.
AF136175 - Homo sapiens RNA helicase mRNA, complete cds.
KU159421 - Homo sapiens DEAD box polypeptide 19A mRNA, complete cds.
CU678542 - Synthetic construct Homo sapiens gateway clone IMAGE:100017349 5' read DDX19B mRNA.
AK001988 - Homo sapiens cDNA FLJ11126 fis, clone PLACE1006196, weakly similar to PUTATIVE ATP-DEPENDENT RNA HELICASE C12C2.06.
CR749227 - Homo sapiens mRNA; cDNA DKFZp686C21137 (from clone DKFZp686C21137).
AK310804 - Homo sapiens cDNA, FLJ17846.
AK310604 - Homo sapiens cDNA, FLJ17646.
AK223262 - Homo sapiens mRNA for DDX19-like protein variant, clone: STM06760.
AL832970 - Homo sapiens mRNA; cDNA DKFZp666D212 (from clone DKFZp666D212).
BC005162 - Homo sapiens DEAD (Asp-Glu-Ala-As) box polypeptide 19A, mRNA (cDNA clone MGC:4651 IMAGE:3530064), complete cds.
BC006544 - Homo sapiens DEAD (Asp-Glu-Ala-As) box polypeptide 19A, mRNA (cDNA clone MGC:2395 IMAGE:2964377), complete cds.
LF384456 - JP 2014500723-A/191959: Polycomb-Associated Non-Coding RNAs.
BC137496 - Homo sapiens DEAD (Asp-Glu-Ala-As) box polypeptide 19A, mRNA (cDNA clone MGC:169119 IMAGE:9021496), complete cds.
BC137497 - Homo sapiens DEAD (Asp-Glu-Ala-As) box polypeptide 19A, mRNA (cDNA clone MGC:169120 IMAGE:9021497), complete cds.
AK299539 - Homo sapiens cDNA FLJ50635 complete cds, highly similar to ATP-dependent RNA helicase DDX19A (EC 3.6.1.-).
CU675025 - Synthetic construct Homo sapiens gateway clone IMAGE:100020271 5' read DDX19A mRNA.
JF432269 - Synthetic construct Homo sapiens clone IMAGE:100073441 DEAD (Asp-Glu-Ala-As) box polypeptide 19A (DDX19A) gene, encodes complete protein.
KJ894182 - Synthetic construct Homo sapiens clone ccsbBroadEn_03576 DDX19A gene, encodes complete protein.
MA620033 - JP 2018138019-A/191959: Polycomb-Associated Non-Coding RNAs.
BC025771 - Homo sapiens DEAD (Asp-Glu-Ala-As) box polypeptide 19A, mRNA (cDNA clone IMAGE:5210159), with apparent retained intron.
AK125701 - Homo sapiens cDNA FLJ43713 fis, clone TESOP2004173.
JD359336 - Sequence 340360 from Patent EP1572962.
JD512407 - Sequence 493431 from Patent EP1572962.
AK310808 - Homo sapiens cDNA, FLJ17850.
AK299504 - Homo sapiens cDNA FLJ52463 complete cds, highly similar to ATP-dependent RNA helicase DDX19A (EC 3.6.1.-).
AL832901 - Homo sapiens mRNA; cDNA DKFZp762C1313 (from clone DKFZp762C1313).
AB209401 - Homo sapiens mRNA for DDX19-like protein variant protein.
LF374626 - JP 2014500723-A/182129: Polycomb-Associated Non-Coding RNAs.
AK094061 - Homo sapiens cDNA FLJ36742 fis, clone UTERU2013926.
LF374625 - JP 2014500723-A/182128: Polycomb-Associated Non-Coding RNAs.
LF374624 - JP 2014500723-A/182127: Polycomb-Associated Non-Coding RNAs.
LF374611 - JP 2014500723-A/182114: Polycomb-Associated Non-Coding RNAs.
LF374623 - JP 2014500723-A/182126: Polycomb-Associated Non-Coding RNAs.
JD464018 - Sequence 445042 from Patent EP1572962.
LF374610 - JP 2014500723-A/182113: Polycomb-Associated Non-Coding RNAs.
JD057652 - Sequence 38676 from Patent EP1572962.
JD523681 - Sequence 504705 from Patent EP1572962.
JD371453 - Sequence 352477 from Patent EP1572962.
JD279327 - Sequence 260351 from Patent EP1572962.
JD121858 - Sequence 102882 from Patent EP1572962.
JD363386 - Sequence 344410 from Patent EP1572962.
LF374609 - JP 2014500723-A/182112: Polycomb-Associated Non-Coding RNAs.
JD167193 - Sequence 148217 from Patent EP1572962.
JD556772 - Sequence 537796 from Patent EP1572962.
JD394379 - Sequence 375403 from Patent EP1572962.
JD290381 - Sequence 271405 from Patent EP1572962.
JD266275 - Sequence 247299 from Patent EP1572962.
JD087889 - Sequence 68913 from Patent EP1572962.
JD249674 - Sequence 230698 from Patent EP1572962.
JD238059 - Sequence 219083 from Patent EP1572962.
JD238058 - Sequence 219082 from Patent EP1572962.
JD533322 - Sequence 514346 from Patent EP1572962.
JD217609 - Sequence 198633 from Patent EP1572962.
JD291486 - Sequence 272510 from Patent EP1572962.
JD341437 - Sequence 322461 from Patent EP1572962.
JD089488 - Sequence 70512 from Patent EP1572962.
JD112305 - Sequence 93329 from Patent EP1572962.
JD078376 - Sequence 59400 from Patent EP1572962.
JD526389 - Sequence 507413 from Patent EP1572962.
MA610203 - JP 2018138019-A/182129: Polycomb-Associated Non-Coding RNAs.
MA610202 - JP 2018138019-A/182128: Polycomb-Associated Non-Coding RNAs.
MA610201 - JP 2018138019-A/182127: Polycomb-Associated Non-Coding RNAs.
MA610188 - JP 2018138019-A/182114: Polycomb-Associated Non-Coding RNAs.
MA610200 - JP 2018138019-A/182126: Polycomb-Associated Non-Coding RNAs.
MA610187 - JP 2018138019-A/182113: Polycomb-Associated Non-Coding RNAs.
MA610186 - JP 2018138019-A/182112: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RPL0, B4DRZ7, DD19A_HUMAN, DDX19L, ENST00000302243.1, ENST00000302243.10, ENST00000302243.11, ENST00000302243.2, ENST00000302243.3, ENST00000302243.4, ENST00000302243.5, ENST00000302243.6, ENST00000302243.7, ENST00000302243.8, ENST00000302243.9, NR_135296, Q53FM0, Q9NUU7, uc317mzi.1, uc317mzi.2
UCSC ID: ENST00000302243.12_4
RefSeq Accession: NM_018332.5
Protein: Q9NUU7 (aka DD19A_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
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