ID:DX39A_HUMAN DESCRIPTION: RecName: Full=ATP-dependent RNA helicase DDX39A; EC=3.6.4.13; AltName: Full=DEAD box protein 39; AltName: Full=Nuclear RNA helicase URH49; FUNCTION: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus. CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate. SUBUNIT: Binds ALYREF/THOC4 and DDX39B/BAT1. Interacts with SARNP. Interacts with human cytomegalovirus/HHV-5 protein UL69. SUBCELLULAR LOCATION: Nucleus (By similarity). TISSUE SPECIFICITY: Detected in testis, and at lower levels in brain, kidney, lung, thymus, spleen and salivary gland. INDUCTION: Up-regulated in proliferating cells. Present at low levels in quiescent cells. SIMILARITY: Belongs to the DEAD box helicase family. DECD subfamily. SIMILARITY: Contains 1 helicase ATP-binding domain. SIMILARITY: Contains 1 helicase C-terminal domain. SEQUENCE CAUTION: Sequence=BAB15509.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O00148
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AL512698 - Homo sapiens mRNA; cDNA DKFZp547B159 (from clone DKFZp547B159). AK026614 - Homo sapiens cDNA: FLJ22961 fis, clone KAT10214. BC001009 - Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 39, mRNA (cDNA clone MGC:8417 IMAGE:2820926), complete cds. BC032128 - Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 39, mRNA (cDNA clone MGC:29546 IMAGE:5017293), complete cds. BC010455 - Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 39, mRNA (cDNA clone IMAGE:4155840), with apparent retained intron. AK301847 - Homo sapiens cDNA FLJ55484 complete cds, highly similar to ATP-dependent RNA helicase DDX39 (EC 3.6.1.-). U90426 - Human nuclear RNA helicase, complete cds. JD055091 - Sequence 36115 from Patent EP1572962. JD522530 - Sequence 503554 from Patent EP1572962. KJ892962 - Synthetic construct Homo sapiens clone ccsbBroadEn_02356 DDX39A gene, encodes complete protein. DQ891387 - Synthetic construct clone IMAGE:100004017; FLH176433.01X; RZPDo839D03122D DEAD (Asp-Glu-Ala-Asp) box polypeptide 39 (DDX39) gene, encodes complete protein. DQ894563 - Synthetic construct Homo sapiens clone IMAGE:100009023; FLH176432.01L; RZPDo839D03121D DEAD (Asp-Glu-Ala-Asp) box polypeptide 39 (DDX39) gene, encodes complete protein. JD185987 - Sequence 167011 from Patent EP1572962. JD143141 - Sequence 124165 from Patent EP1572962. JD460909 - Sequence 441933 from Patent EP1572962. KJ902076 - Synthetic construct Homo sapiens clone ccsbBroadEn_11470 DDX39A gene, encodes complete protein. CU689284 - Synthetic construct Homo sapiens gateway clone IMAGE:100021890 5' read DDX39 mRNA. JD482328 - Sequence 463352 from Patent EP1572962. JD534536 - Sequence 515560 from Patent EP1572962. JD386121 - Sequence 367145 from Patent EP1572962. JD150545 - Sequence 131569 from Patent EP1572962. JD187427 - Sequence 168451 from Patent EP1572962. AB254849 - Homo sapiens DDX39 mRNA for DEAD (Asp-Glu-Ala-Asp) box polypeptide 39 transcript variant, complete cds. KJ902077 - Synthetic construct Homo sapiens clone ccsbBroadEn_11471 DDX39A gene, encodes complete protein. CU679723 - Synthetic construct Homo sapiens gateway clone IMAGE:100023448 5' read DDX39 mRNA. CU674496 - Synthetic construct Homo sapiens gateway clone IMAGE:100017246 5' read DDX39 mRNA. AK293911 - Homo sapiens cDNA FLJ59857 complete cds, moderately similar to ATP-dependent RNA helicase DDX39 (EC 3.6.1.-). JD022808 - Sequence 3832 from Patent EP1572962. JD031729 - Sequence 12753 from Patent EP1572962. JD023759 - Sequence 4783 from Patent EP1572962. JD030529 - Sequence 11553 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O00148 (Reactome details) participates in the following event(s):
R-HSA-8849157 TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally R-HSA-159101 NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) R-HSA-72185 mRNA polyadenylation R-HSA-72180 Cleavage of mRNA at the 3'-end R-HSA-72187 mRNA 3'-end processing R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-72202 Transport of Mature Transcript to Cytoplasm R-HSA-8953854 Metabolism of RNA R-HSA-109688 Cleavage of Growing Transcript in the Termination Region R-HSA-73856 RNA Polymerase II Transcription Termination R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
