Human Gene DENR (ENST00000280557.11_4) from GENCODE V47lift37
  Description: density regulated re-initiation and release factor (from RefSeq NM_003677.5)
Gencode Transcript: ENST00000280557.11_4
Gencode Gene: ENSG00000139726.11_7
Transcript (Including UTRs)
   Position: hg19 chr12:123,237,371-123,255,611 Size: 18,241 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr12:123,238,249-123,253,625 Size: 15,377 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:123,237,371-123,255,611)mRNA (may differ from genome)Protein (198 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: DENR_HUMAN
DESCRIPTION: RecName: Full=Density-regulated protein; Short=DRP; AltName: Full=Protein DRP1; AltName: Full=Smooth muscle cell-associated protein 3; Short=SMAP-3;
FUNCTION: May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Plays a role in the modulation of the translational profile of a subset of cancer- related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1.
SUBUNIT: Interacts with MCTS1.
INTERACTION: Q8WX92:COBRA1; NbExp=2; IntAct=EBI-716083, EBI-347721;
TISSUE SPECIFICITY: Highly expressed in heart and skeletal muscle and moderately expressed in the brain, placenta, liver and pancreas. Weakly expressed in the lung and kidney.
INDUCTION: Up-regulated with increasing cell-density by HNRNPD. Up-regulated in ovarian and breast cancer cells by ERBB2 overexpression. Not induced by TGFB1.
SIMILARITY: Belongs to the DENR family.
SIMILARITY: Contains 1 SUI1 domain.
SEQUENCE CAUTION: Sequence=AAC02985.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/DENRID40295ch12q24.html";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: DENR
Diseases sorted by gene-association score: pleomorphic adenoma carcinoma (16), charcot-marie-tooth disease, axonal, type 2l (9)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 35.78 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 762.98 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -60.80136-0.447 Picture PostScript Text
3' UTR -541.601986-0.273 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005873 - Drp1
IPR001950 - TIF_SUI1

Pfam Domains:
PF01253 - Translation initiation factor SUI1

SCOP Domains:
55159 - eIF1-like

ModBase Predicted Comparative 3D Structure on O43583
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 RGDEnsembl WormBaseSGD
    Protein SequenceProtein Sequence
    AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0003729 mRNA binding
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0043022 ribosome binding

Biological Process:
GO:0001731 formation of translation preinitiation complex
GO:0002188 translation reinitiation
GO:0006412 translation
GO:0006413 translational initiation
GO:0032790 ribosome disassembly
GO:0075522 IRES-dependent viral translational initiation

Cellular Component:
GO:0005575 cellular_component
GO:0070992 translation initiation complex
GO:0005840 ribosome


-  Descriptions from all associated GenBank mRNAs
  AF038554 - Homo sapiens density regulated protein drp1 mRNA, partial cds.
AK299463 - Homo sapiens cDNA FLJ60140 complete cds, highly similar to Density-regulated protein.
AB014731 - Homo sapiens mRNA for SMAP-3, complete cds.
JD234826 - Sequence 215850 from Patent EP1572962.
BC007860 - Homo sapiens density-regulated protein, mRNA (cDNA clone MGC:14387 IMAGE:4300744), complete cds.
BC000925 - Homo sapiens cDNA clone IMAGE:3447042, containing frame-shift errors.
CU675841 - Synthetic construct Homo sapiens gateway clone IMAGE:100016759 5' read DENR mRNA.
HQ447117 - Synthetic construct Homo sapiens clone IMAGE:100070404; CCSB005188_01 density-regulated protein (DENR) gene, encodes complete protein.
KJ892563 - Synthetic construct Homo sapiens clone ccsbBroadEn_01957 DENR gene, encodes complete protein.
AF103800 - Homo sapiens clone H14 unknown mRNA.
JD501282 - Sequence 482306 from Patent EP1572962.
JD110633 - Sequence 91657 from Patent EP1572962.
JD112889 - Sequence 93913 from Patent EP1572962.
JD090685 - Sequence 71709 from Patent EP1572962.
JD299801 - Sequence 280825 from Patent EP1572962.
JD061370 - Sequence 42394 from Patent EP1572962.
JD061369 - Sequence 42393 from Patent EP1572962.
JD428443 - Sequence 409467 from Patent EP1572962.
JD550417 - Sequence 531441 from Patent EP1572962.
JD234310 - Sequence 215334 from Patent EP1572962.
JD234311 - Sequence 215335 from Patent EP1572962.
JD293854 - Sequence 274878 from Patent EP1572962.
JD194464 - Sequence 175488 from Patent EP1572962.
JD536583 - Sequence 517607 from Patent EP1572962.
JD514047 - Sequence 495071 from Patent EP1572962.
JD514048 - Sequence 495072 from Patent EP1572962.
JD070009 - Sequence 51033 from Patent EP1572962.
JD070010 - Sequence 51034 from Patent EP1572962.
JD397316 - Sequence 378340 from Patent EP1572962.
JD121114 - Sequence 102138 from Patent EP1572962.
JD381331 - Sequence 362355 from Patent EP1572962.
JD381332 - Sequence 362356 from Patent EP1572962.
JD362518 - Sequence 343542 from Patent EP1572962.
JD345837 - Sequence 326861 from Patent EP1572962.
JD254759 - Sequence 235783 from Patent EP1572962.
JD264740 - Sequence 245764 from Patent EP1572962.
BC012148 - Homo sapiens cDNA clone IMAGE:4553050, **** WARNING: chimeric clone ****.
JD513971 - Sequence 494995 from Patent EP1572962.
JD379771 - Sequence 360795 from Patent EP1572962.
JD312245 - Sequence 293269 from Patent EP1572962.
JD549032 - Sequence 530056 from Patent EP1572962.
JD383872 - Sequence 364896 from Patent EP1572962.
JD267050 - Sequence 248074 from Patent EP1572962.
JD521732 - Sequence 502756 from Patent EP1572962.
JD086707 - Sequence 67731 from Patent EP1572962.
JD516429 - Sequence 497453 from Patent EP1572962.
JD241661 - Sequence 222685 from Patent EP1572962.
JD245309 - Sequence 226333 from Patent EP1572962.
JD051947 - Sequence 32971 from Patent EP1572962.
JD046585 - Sequence 27609 from Patent EP1572962.
JD492732 - Sequence 473756 from Patent EP1572962.
JD378489 - Sequence 359513 from Patent EP1572962.
JD409724 - Sequence 390748 from Patent EP1572962.
JD280815 - Sequence 261839 from Patent EP1572962.
JD559451 - Sequence 540475 from Patent EP1572962.
JD559452 - Sequence 540476 from Patent EP1572962.
JD109588 - Sequence 90612 from Patent EP1572962.
JD182105 - Sequence 163129 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: DENR_HUMAN, DRP1, ENST00000280557.1, ENST00000280557.10, ENST00000280557.2, ENST00000280557.3, ENST00000280557.4, ENST00000280557.5, ENST00000280557.6, ENST00000280557.7, ENST00000280557.8, ENST00000280557.9, H14, NM_003677, O43583, Q9H3U6, Q9UKZ0, uc317jtz.1, uc317jtz.2
UCSC ID: ENST00000280557.11_4
RefSeq Accession: NM_003677.5
Protein: O43583 (aka DENR_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.