ID:DPTOR_HUMAN DESCRIPTION: RecName: Full=DEP domain-containing mTOR-interacting protein; AltName: Full=DEP domain-containing protein 6; FUNCTION: Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes. SUBUNIT: Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PROTOR1, RICTOR, MAPKAP1 and DEPTOR. Interacts (via PDZ domain) with MTOR; interacts with MTOR within both mammalian target of rapamycin complexes mTORC1 and mTORC2. INTERACTION: P42345:MTOR; NbExp=5; IntAct=EBI-2359040, EBI-359260; P42346:Mtor (xeno); NbExp=2; IntAct=EBI-2359040, EBI-1571489; INDUCTION: Expression is negatively regulated by both mTORC1 and mTORC2 (at protein level). PTM: Phosphorylated. Phosphorylation weakens interaction with MTOR within mTORC1 and mTORC2. SIMILARITY: Contains 2 DEP domains. SIMILARITY: Contains 1 PDZ (DHR) domain. SEQUENCE CAUTION: Sequence=BAB14723.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8TB45
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006469 negative regulation of protein kinase activity GO:0032007 negative regulation of TOR signaling GO:0035556 intracellular signal transduction GO:0045792 negative regulation of cell size GO:2001236 regulation of extrinsic apoptotic signaling pathway
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
