Human Gene DHRS3 (ENST00000616661.5_7) from GENCODE V47lift37
  Description: dehydrogenase/reductase 3, transcript variant 1 (from RefSeq NM_004753.7)
Gencode Transcript: ENST00000616661.5_7
Gencode Gene: ENSG00000162496.10_12
Transcript (Including UTRs)
   Position: hg19 chr1:12,627,939-12,678,216 Size: 50,278 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr1:12,628,369-12,677,353 Size: 48,985 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:12,627,939-12,678,216)mRNA (may differ from genome)Protein (302 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: DHRS3_HUMAN
DESCRIPTION: RecName: Full=Short-chain dehydrogenase/reductase 3; EC=1.1.1.300; AltName: Full=DD83.1; AltName: Full=Retinal short-chain dehydrogenase/reductase 1; Short=retSDR1;
FUNCTION: Catalyzes the reduction of all-trans-retinal to all- trans-retinol in the presence of NADPH.
CATALYTIC ACTIVITY: All-trans-retinol + NADP(+) = all-trans- retinal + NADPH.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
TISSUE SPECIFICITY: Widely expressed with highest levels found in heart, placenta, lung, liver, kidney, pancreas, thyroid, testis, stomach, trachea and spinal cord. Lower levels found in skeletal muscle, intestine and lymph node. No expression detected in brain. In the retina, expressed in cone but not rod outer segments.
INDUCTION: By retinoic acid.
MISCELLANEOUS: Located in a region of chromosome 1 which is often deleted in aggressive neuroblastoma tumors.
SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
SEQUENCE CAUTION: Sequence=AAQ88460.1; Type=Frameshift; Positions=15;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: DHRS3
Diseases sorted by gene-association score: neuroblastoma (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -293.00862-0.340 Picture PostScript Text
3' UTR -141.60430-0.329 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002198 - DH_sc/Rdtase_SDR
IPR002347 - Glc/ribitol_DH
IPR016040 - NAD(P)-bd_dom

Pfam Domains:
PF00106 - short chain dehydrogenase
PF02719 - Polysaccharide biosynthesis protein
PF08659 - KR domain
PF13561 - Enoyl-(Acyl carrier protein) reductase

SCOP Domains:
51735 - NAD(P)-binding Rossmann-fold domains
102645 - CoaB-like

ModBase Predicted Comparative 3D Structure on O75911
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004745 retinol dehydrogenase activity
GO:0009055 electron carrier activity
GO:0016491 oxidoreductase activity
GO:0052650 NADP-retinol dehydrogenase activity

Biological Process:
GO:0001523 retinoid metabolic process
GO:0003151 outflow tract morphogenesis
GO:0007601 visual perception
GO:0022900 electron transport chain
GO:0030278 regulation of ossification
GO:0042572 retinol metabolic process
GO:0048387 negative regulation of retinoic acid receptor signaling pathway
GO:0055114 oxidation-reduction process
GO:0060021 palate development
GO:0060349 bone morphogenesis
GO:0060411 cardiac septum morphogenesis

Cellular Component:
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042622 photoreceptor outer segment membrane


-  Descriptions from all associated GenBank mRNAs
  KJ897985 - Synthetic construct Homo sapiens clone ccsbBroadEn_07379 DHRS3 gene, encodes complete protein.
AK225057 - Homo sapiens mRNA for dehydrogenase/reductase (SDR family) member 3 variant, clone: adSH01337.
AF061741 - Homo sapiens retinal short-chain dehydrogenase/reductase retSDR1 mRNA, complete cds.
AK222593 - Homo sapiens mRNA for dehydrogenase/reductase (SDR family) member 3 variant, clone: CAS07716.
BC002730 - Homo sapiens dehydrogenase/reductase (SDR family) member 3, mRNA (cDNA clone MGC:3784 IMAGE:3630840), complete cds.
BX648476 - Homo sapiens mRNA; cDNA DKFZp686A22160 (from clone DKFZp686A22160).
JD249155 - Sequence 230179 from Patent EP1572962.
JD439342 - Sequence 420366 from Patent EP1572962.
JD092483 - Sequence 73507 from Patent EP1572962.
JD512310 - Sequence 493334 from Patent EP1572962.
JD093830 - Sequence 74854 from Patent EP1572962.
JD402932 - Sequence 383956 from Patent EP1572962.
JD047854 - Sequence 28878 from Patent EP1572962.
JD495841 - Sequence 476865 from Patent EP1572962.
JD493557 - Sequence 474581 from Patent EP1572962.
JD216249 - Sequence 197273 from Patent EP1572962.
DQ893006 - Synthetic construct clone IMAGE:100005636; FLH191614.01X; RZPDo839F0277D dehydrogenase/reductase (SDR family) member 3 (DHRS3) gene, encodes complete protein.
AK312961 - Homo sapiens cDNA, FLJ93419, Homo sapiens short-chain dehydrogenase/reductase 1 (SDR1), mRNA.
DQ896252 - Synthetic construct Homo sapiens clone IMAGE:100010712; FLH191610.01L; RZPDo839F0267D dehydrogenase/reductase (SDR family) member 3 (DHRS3) gene, encodes complete protein.
CU678154 - Synthetic construct Homo sapiens gateway clone IMAGE:100018778 5' read DHRS3 mRNA.
AK310202 - Homo sapiens cDNA, FLJ17244.
AY358093 - Homo sapiens clone DNA49828 SDR1 (UNQ2424) mRNA, complete cds.
DQ426870 - Homo sapiens dehydrogenase/reductase member 3 (DHRS3) mRNA, partial cds, alternatively spliced.
DQ426869 - Homo sapiens dehydrogenase/reductase member 3 (DHRS3) mRNA, partial cds, alternatively spliced.
AK309282 - Homo sapiens cDNA, FLJ99323.
JD289148 - Sequence 270172 from Patent EP1572962.
JD390891 - Sequence 371915 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
PWY-6857 - retinol biosynthesis
PWY-6861 - the visual cycle I (vertebrates)

Reactome (by CSHL, EBI, and GO)

Protein O75911 (Reactome details) participates in the following event(s):

R-HSA-2465940 atRAL is reduced to atROL
R-HSA-5419165 RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL
R-HSA-2187335 The retinoid cycle in cones (daylight vision)
R-HSA-2187338 Visual phototransduction
R-HSA-5365859 RA biosynthesis pathway
R-HSA-418594 G alpha (i) signalling events
R-HSA-5362517 Signaling by Retinoic Acid
R-HSA-388396 GPCR downstream signalling
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: B2R7F3, DHRS3_HUMAN, ENST00000616661.1, ENST00000616661.2, ENST00000616661.3, ENST00000616661.4, NM_004753, O75911, Q5VUY3, Q6UY38, Q9BUC8, RDH17, SDR16C1, uc327qpz.1, uc327qpz.2, UNQ2424/PRO4983
UCSC ID: ENST00000616661.5_7
RefSeq Accession: NM_004753.7
Protein: O75911 (aka DHRS3_HUMAN or DHS3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.