Human Gene DHRS7 (ENST00000557185.6_8) from GENCODE V47lift37
  Description: dehydrogenase/reductase 7, transcript variant 1 (from RefSeq NM_016029.4)
Gencode Transcript: ENST00000557185.6_8
Gencode Gene: ENSG00000100612.14_12
Transcript (Including UTRs)
   Position: hg19 chr14:60,610,837-60,632,116 Size: 21,280 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr14:60,611,684-60,632,027 Size: 20,344 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:60,610,837-60,632,116)mRNA (may differ from genome)Protein (339 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: DHRS7_HUMAN
DESCRIPTION: RecName: Full=Dehydrogenase/reductase SDR family member 7; EC=1.1.-.-; AltName: Full=Retinal short-chain dehydrogenase/reductase 4; Short=retSDR4; Flags: Precursor;
SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D013749 Tetrachlorodibenzodioxin
  • C006780 bisphenol A
  • C576882 1-(2-trifluoromethoxyphenyl)-2-nitroethanone
  • C029141 2,2,5,7,8-pentamethyl-1-hydroxychroman
  • C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester
  • C009505 4,4'-diaminodiphenylmethane
  • D000082 Acetaminophen
  • D001564 Benzo(a)pyrene
  • D002994 Clofibrate
  • D019327 Copper Sulfate
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 93.01 RPKM in Muscle - Skeletal
Total median expression: 1098.97 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -38.1089-0.428 Picture PostScript Text
3' UTR -206.60847-0.244 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002198 - DH_sc/Rdtase_SDR
IPR002347 - Glc/ribitol_DH
IPR016040 - NAD(P)-bd_dom
IPR020904 - Sc_DH/Rdtase_CS

Pfam Domains:
PF00106 - short chain dehydrogenase
PF08659 - KR domain
PF13561 - Enoyl-(Acyl carrier protein) reductase

SCOP Domains:
51735 - NAD(P)-binding Rossmann-fold domains
53271 - PRTase-like

ModBase Predicted Comparative 3D Structure on Q9Y394
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0016491 oxidoreductase activity

Biological Process:
GO:0055114 oxidation-reduction process

Cellular Component:
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  BC000637 - Homo sapiens dehydrogenase/reductase (SDR family) member 7, mRNA (cDNA clone MGC:681 IMAGE:3344010), complete cds.
AL117420 - Homo sapiens mRNA; cDNA DKFZp564H1664 (from clone DKFZp564H1664).
AY359031 - Homo sapiens clone DNA36343 oxidoreductase/S-2 H (UNQ285) mRNA, complete cds.
AF151844 - Homo sapiens CGI-86 protein mRNA, complete cds.
AF126782 - Homo sapiens retinal short-chain dehydrogenase/reductase retSDR4 mRNA, complete cds.
BC007337 - Homo sapiens dehydrogenase/reductase (SDR family) member 7, mRNA (cDNA clone MGC:15217 IMAGE:3616802), complete cds.
JD303638 - Sequence 284662 from Patent EP1572962.
JD334540 - Sequence 315564 from Patent EP1572962.
AK313285 - Homo sapiens cDNA, FLJ93797, Homo sapiens dehydrogenase/reductase (SDR family) member 7 (DHRS7),mRNA.
KJ893957 - Synthetic construct Homo sapiens clone ccsbBroadEn_03351 DHRS7 gene, encodes complete protein.
JD407000 - Sequence 388024 from Patent EP1572962.
JD396699 - Sequence 377723 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2R896, CGI-86, DHRS7 , DHRS7A, DHRS7_HUMAN, ENST00000557185.1, ENST00000557185.2, ENST00000557185.3, ENST00000557185.4, ENST00000557185.5, NM_016029, Q9UKU2, Q9Y394, RETSDR4 , SDR34C1 , uc325jrr.1, uc325jrr.2, UNQ285/PRO3448
UCSC ID: ENST00000557185.6_8
RefSeq Accession: NM_016029.4
Protein: Q9Y394 (aka DHRS7_HUMAN or DHS7_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.