Human Gene DHX16 (ENST00000376442.8_7) from GENCODE V47lift37

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Description: DEAH-box helicase 16, transcript variant 1 (from RefSeq NM_003587.5)
Gencode Transcript: ENST00000376442.8_7
Gencode Gene: ENSG00000204560.10_11
Transcript (Including UTRs)
Position: hg19 chr6:30,620,904-30,640,783 Size: 19,880 Total Exon Count: 20 Strand: -
Coding Region
Position: hg19 chr6:30,621,019-30,640,618 Size: 19,600 Coding Exon Count: 20

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr6:30,620,904-30,640,783)			mRNA (may differ from genome)		Protein (1041 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: Q5SQH4_HUMAN DESCRIPTION: SubName: Full=DBP2 protein; SubName: Full=DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 16; SubName: Full=DEAH (Asp-Glu-Ala-His) box polypeptide 16; SubName: Full=DEAH (Asp-Glu-Ala-His) box polypeptide 16, isoform CRA_e; SubName: Full=cDNA, FLJ92560, highly similar to Homo sapiens DEAH (Asp-Glu-Ala-His) box polypeptide 16 (DHX16), mRNA; SIMILARITY: Contains 1 helicase ATP-binding domain. SIMILARITY: Contains 1 helicase C-terminal domain.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D013749 Tetrachlorodibenzodioxin D000638 Amiodarone D001553 Benzbromarone D019256 Cadmium Chloride D002330 Carmustine D002994 Clofibrate D019327 Copper Sulfate D004997 Ethinyl Estradiol D005001 Ethionine D009853 Omeprazole more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 35.76 RPKM in Testis Total median expression: 705.61 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-73.50	165	-0.445	Picture	PostScript	Text
3' UTR	-18.40	115	-0.160	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR011545 - DNA/RNA_helicase_DEAD/DEAH_N
IPR002464 - DNA/RNA_helicase_DEAH_CS
IPR011709 - DUF1605
IPR007502 - Helicase-assoc_dom
IPR014001 - Helicase_ATP-bd
IPR001650 - Helicase_C

Pfam Domains:
PF00270 - DEAD/DEAH box helicase
PF00271 - Helicase conserved C-terminal domain
PF04408 - Helicase associated domain (HA2)
PF07717 - Oligonucleotide/oligosaccharide-binding (OB)-fold

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on Q5SQH4


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details		Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000166 nucleotide binding GO:0003676 nucleic acid binding GO:0004386 helicase activity GO:0005524 ATP binding GO:0016787 hydrolase activity Cellular Component: GO:0005654 nucleoplasm

Descriptions from all associated GenBank mRNAs


	AB011149 - Homo sapiens KIAA0577 mRNA for KIAA0577 protein. AB001601 - Homo sapiens DBP2 mRNA for ATP-dependent RNA helicase #3, complete cds. AF119860 - Homo sapiens PRO2014 mRNA, complete cds. AK302721 - Homo sapiens cDNA FLJ53577 complete cds, highly similar to pre-mRNA-splicing factor ATP-dependentRNA helicase DHX16 (EC 3.6.1.-). BC008825 - Homo sapiens DEAH (Asp-Glu-Ala-His) box polypeptide 16, mRNA (cDNA clone MGC:12779 IMAGE:4100320), complete cds. BC009392 - Homo sapiens DEAH (Asp-Glu-Ala-His) box polypeptide 16, mRNA (cDNA clone MGC:15329 IMAGE:4136069), complete cds. JD051285 - Sequence 32309 from Patent EP1572962. AK312264 - Homo sapiens cDNA, FLJ92560, highly similar to Homo sapiens DEAH (Asp-Glu-Ala-His) box polypeptide 16 (DHX16), mRNA. KJ901879 - Synthetic construct Homo sapiens clone ccsbBroadEn_11273 DHX16 gene, encodes complete protein. DQ895906 - Synthetic construct Homo sapiens clone IMAGE:100010366; FLH189681.01L; RZPDo839H1164D DEAH (Asp-Glu-Ala-His) box polypeptide 16 (DHX16) gene, encodes complete protein. AB385352 - Synthetic construct DNA, clone: pF1KA0577, Homo sapiens DHX16 gene for pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16, complete cds, without stop codon, in Flexi system. CU679131 - Synthetic construct Homo sapiens gateway clone IMAGE:100017882 5' read DHX16 mRNA. BC002789 - Homo sapiens DEAH (Asp-Glu-Ala-His) box polypeptide 16, mRNA (cDNA clone IMAGE:3618066), partial cds. JD533355 - Sequence 514379 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: DBP2 , DHX16 , ENST00000376442.1, ENST00000376442.2, ENST00000376442.3, ENST00000376442.4, ENST00000376442.5, ENST00000376442.6, ENST00000376442.7, hCG_26008 , NM_003587, Q5SQH4, Q5SQH4_HUMAN, uc318myf.1, uc318myf.2 UCSC ID: ENST00000376442.8_7 RefSeq Accession: NM_003587.5 Protein: Q5SQH4

Gene Model Information


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Methods, Credits, and Use Restrictions


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