ID:DKK3_HUMAN DESCRIPTION: RecName: Full=Dickkopf-related protein 3; Short=Dickkopf-3; Short=Dkk-3; Short=hDkk-3; Flags: Precursor; FUNCTION: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). SUBUNIT: Interacts with LRP5 and LRP6 (By similarity). SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Highest expression in heart, brain, and spinal cord. DOMAIN: The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6 (By similarity). PTM: N- and O-glycosylated. SIMILARITY: Belongs to the dickkopf family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF04706 - Dickkopf N-terminal cysteine-rich region
ModBase Predicted Comparative 3D Structure on Q9UBP4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
