Human Gene DLG5 (ENST00000372391.7_7) from GENCODE V47lift37
  Description: discs large MAGUK scaffold protein 5 (from RefSeq NM_004747.4)
Gencode Transcript: ENST00000372391.7_7
Gencode Gene: ENSG00000151208.17_12
Transcript (Including UTRs)
   Position: hg19 chr10:79,550,549-79,686,513 Size: 135,965 Total Exon Count: 32 Strand: -
Coding Region
   Position: hg19 chr10:79,552,198-79,686,278 Size: 134,081 Coding Exon Count: 32 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:79,550,549-79,686,513)mRNA (may differ from genome)Protein (1919 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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-  Comments and Description Text from UniProtKB
  ID: DLG5_HUMAN
DESCRIPTION: RecName: Full=Disks large homolog 5; AltName: Full=Discs large protein P-dlg; AltName: Full=Placenta and prostate DLG;
FUNCTION: May play a role at the plasma membrane in the maintenance of the structure of epithelial cells and in the transmission of extracellular signals to the membrane and cytoskeleton.
SUBUNIT: Interacts with MPP1. Interacts with CTNNB1 and with the third SH3 domain of SORBS3 to form a ternary complex.
SUBCELLULAR LOCATION: Cell junction. Cell membrane; Peripheral membrane protein. Note=Localized at sites of cell-cell contact.
TISSUE SPECIFICITY: Highly expressed in the placenta and prostate. Expressed at a lower level in the thyroid, spinal cord, trachea, adrenal gland, skeletal muscle, pancreas, heart, brain, liver and kidney. A short splice product shows more limited expression, being absent from at least the brain.
SIMILARITY: Belongs to the MAGUK family.
SIMILARITY: Contains 1 guanylate kinase-like domain.
SIMILARITY: Contains 4 PDZ (DHR) domains.
SIMILARITY: Contains 1 SH3 domain.
SEQUENCE CAUTION: Sequence=AAI17696.1; Type=Erroneous initiation; Sequence=BAA25509.2; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: DLG5
Diseases sorted by gene-association score: inflammatory bowel disease 5 (8), inflammatory bowel disease 2 (7), ileocolitis (6), crohn's disease (3), intestinal disease (1), familial atrial fibrillation (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 36.53 RPKM in Adrenal Gland
Total median expression: 618.19 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -145.30235-0.618 Picture PostScript Text
3' UTR -499.601649-0.303 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001315 - CARD
IPR011029 - DEATH-like
IPR006907 - DUF622
IPR008144 - Guanylate_kin
IPR008145 - Guanylate_kin/L-typ_Ca_channel
IPR001478 - PDZ
IPR001452 - SH3_domain

Pfam Domains:
PF00595 - PDZ domain
PF00625 - Guanylate kinase
PF04822 - Takusan
PF16610 - Unstructured region between two PDZ domains on Dlg5
PF17820 - PDZ domain

SCOP Domains:
47986 - DEATH domain
50044 - SH3-domain
50156 - PDZ domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1UIT - NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q8TDM6
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008092 cytoskeletal protein binding
GO:0030159 receptor signaling complex scaffold activity

Biological Process:
GO:0001837 epithelial to mesenchymal transition
GO:0007165 signal transduction
GO:0008285 negative regulation of cell proliferation
GO:0030011 maintenance of cell polarity
GO:0030336 negative regulation of cell migration
GO:0030859 polarized epithelial cell differentiation
GO:0030901 midbrain development
GO:0035331 negative regulation of hippo signaling
GO:0035332 positive regulation of hippo signaling
GO:0035556 intracellular signal transduction
GO:0042130 negative regulation of T cell proliferation
GO:0042981 regulation of apoptotic process
GO:0045176 apical protein localization
GO:0045186 zonula adherens assembly
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
GO:0045880 positive regulation of smoothened signaling pathway
GO:0051965 positive regulation of synapse assembly
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0060999 positive regulation of dendritic spine development
GO:0065003 macromolecular complex assembly
GO:0071896 protein localization to adherens junction
GO:0072205 metanephric collecting duct development
GO:0098609 cell-cell adhesion

Cellular Component:
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005913 cell-cell adherens junction
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0030054 cell junction
GO:0036064 ciliary basal body
GO:0042995 cell projection
GO:0045202 synapse
GO:0045211 postsynaptic membrane


-  Descriptions from all associated GenBank mRNAs
  BC051757 - Homo sapiens discs, large homolog 5 (Drosophila), mRNA (cDNA clone IMAGE:5739535), with apparent retained intron.
BC073996 - Homo sapiens discs, large homolog 5 (Drosophila), mRNA (cDNA clone IMAGE:6178261), partial cds.
BC030250 - Homo sapiens discs, large homolog 5 (Drosophila), mRNA (cDNA clone IMAGE:5309541), partial cds.
BX649131 - Homo sapiens mRNA; cDNA DKFZp686O1548 (from clone DKFZp686O1548).
BC146794 - Homo sapiens discs, large homolog 5 (Drosophila), mRNA (cDNA clone MGC:166895 IMAGE:9007265), complete cds.
AF352034 - Homo sapiens DLG5 mRNA, complete cds.
AB011155 - Homo sapiens KIAA0583 mRNA for KIAA0583 protein.
U61843 - Homo sapiens discs large protein P-dlg mRNA, complete cds.
BC117695 - Homo sapiens discs, large homolog 5 (Drosophila), mRNA (cDNA clone IMAGE:40072323), complete cds.
AK314771 - Homo sapiens cDNA, FLJ95640, highly similar to Homo sapiens discs, large (Drosophila) homolog 5 (DLG5), mRNA.
AB091676 - Homo sapiens mRNA for discs large protein lp-dlg, complete cds.
AB384502 - Synthetic construct DNA, clone: pF1KA0583, Homo sapiens DLG5 gene for discs large homolog 5, complete cds, without stop codon, in Flexi system.
BC002915 - Homo sapiens discs, large homolog 5 (Drosophila), mRNA (cDNA clone IMAGE:3955968), partial cds.
BC013378 - Homo sapiens discs, large homolog 5 (Drosophila), mRNA (cDNA clone IMAGE:3959084), partial cds.
AK122931 - Homo sapiens cDNA FLJ16622 fis, clone TESTI4015145, highly similar to DLG5.
BC015053 - Homo sapiens discs, large homolog 5 (Drosophila), mRNA (cDNA clone IMAGE:3911874), partial cds.
AK055265 - Homo sapiens cDNA FLJ30703 fis, clone FCBBF2001088.
JD229363 - Sequence 210387 from Patent EP1572962.
JD531769 - Sequence 512793 from Patent EP1572962.
JD505189 - Sequence 486213 from Patent EP1572962.
JD312586 - Sequence 293610 from Patent EP1572962.
JD308337 - Sequence 289361 from Patent EP1572962.
JD045412 - Sequence 26436 from Patent EP1572962.
JD291356 - Sequence 272380 from Patent EP1572962.
JD438140 - Sequence 419164 from Patent EP1572962.
JD483386 - Sequence 464410 from Patent EP1572962.
JD423328 - Sequence 404352 from Patent EP1572962.
JD177999 - Sequence 159023 from Patent EP1572962.
JD399835 - Sequence 380859 from Patent EP1572962.
JD151050 - Sequence 132074 from Patent EP1572962.
JD526207 - Sequence 507231 from Patent EP1572962.
JD037365 - Sequence 18389 from Patent EP1572962.
JD095600 - Sequence 76624 from Patent EP1572962.
JD512381 - Sequence 493405 from Patent EP1572962.
JD167242 - Sequence 148266 from Patent EP1572962.
JD319045 - Sequence 300069 from Patent EP1572962.
JD218359 - Sequence 199383 from Patent EP1572962.
JD133271 - Sequence 114295 from Patent EP1572962.
JD136486 - Sequence 117510 from Patent EP1572962.
JD281318 - Sequence 262342 from Patent EP1572962.
JD396914 - Sequence 377938 from Patent EP1572962.
JD118115 - Sequence 99139 from Patent EP1572962.
JD417843 - Sequence 398867 from Patent EP1572962.
JD020141 - Sequence 1165 from Patent EP1572962.
JD020688 - Sequence 1712 from Patent EP1572962.
JD027674 - Sequence 8698 from Patent EP1572962.
BC086867 - Homo sapiens discs, large homolog 5 (Drosophila), mRNA (cDNA clone IMAGE:30377565), with apparent retained intron.
AK055172 - Homo sapiens cDNA FLJ30610 fis, clone CTONG2000589, weakly similar to CHANNEL ASSOCIATED PROTEIN OF SYNAPSE-110.
JD391645 - Sequence 372669 from Patent EP1572962.
JD476268 - Sequence 457292 from Patent EP1572962.
JD470627 - Sequence 451651 from Patent EP1572962.
JD334808 - Sequence 315832 from Patent EP1572962.
JD442674 - Sequence 423698 from Patent EP1572962.
JD385454 - Sequence 366478 from Patent EP1572962.
JD530245 - Sequence 511269 from Patent EP1572962.
JD070885 - Sequence 51909 from Patent EP1572962.
JD196329 - Sequence 177353 from Patent EP1572962.
JD505015 - Sequence 486039 from Patent EP1572962.
JD024973 - Sequence 5997 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A6H8Y3, DLG5_HUMAN, ENST00000372391.1, ENST00000372391.2, ENST00000372391.3, ENST00000372391.4, ENST00000372391.5, ENST00000372391.6, KIAA0583, NM_004747, PDLG, Q149N1, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM6, Q8TDM7, Q9UE73, Q9Y4E3, uc318jwk.1, uc318jwk.2
UCSC ID: ENST00000372391.7_7
RefSeq Accession: NM_004747.4
Protein: Q8TDM6 (aka DLG5_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.