The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P36957
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006091 generation of precursor metabolites and energy GO:0006099 tricarboxylic acid cycle GO:0006103 2-oxoglutarate metabolic process GO:0006104 succinyl-CoA metabolic process GO:0008152 metabolic process GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine
LF209602 - JP 2014500723-A/17105: Polycomb-Associated Non-Coding RNAs. AK289414 - Homo sapiens cDNA FLJ75101 complete cds, highly similar to Homo sapiens dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) (DLST), mRNA. BX248276 - human full-length cDNA clone CS0DI006YM01 of Placenta of Homo sapiens (human). AK299505 - Homo sapiens cDNA FLJ55034 complete cds, highly similar to Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor (EC 2.3.1.61). AK316463 - Homo sapiens cDNA, FLJ79362 complete cds, moderately similar to Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor (EC 2.3.1.61). BC000302 - Homo sapiens dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex), mRNA (cDNA clone MGC:8382 IMAGE:2820348), complete cds. BC001922 - Homo sapiens dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex), mRNA (cDNA clone MGC:3895 IMAGE:2820348), complete cds. BC002735 - Homo sapiens cDNA clone IMAGE:3627724, containing frame-shift errors. BX248764 - human full-length cDNA 5-PRIME end of clone CS0DB006YE12 of Neuroblastoma of Homo sapiens (human). D16373 - Homo sapiens alpha-KG-E2 mRNA for mitochondrial dihydrolipoamide succinyltransferase, complete cds. CR456727 - Homo sapiens full open reading frame cDNA clone RZPDo834B0211D for gene DLST, dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex); complete cds, incl. stopcodon. HQ448281 - Synthetic construct Homo sapiens clone IMAGE:100071684; CCSB003150_02 dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) (DLST) gene, encodes complete protein. KJ896706 - Synthetic construct Homo sapiens clone ccsbBroadEn_06100 DLST gene, encodes complete protein. L37418 - Homo sapiens dihydrolipoamide succinyltransferase (E2K) mRNA, complete cds. MA445179 - JP 2018138019-A/17105: Polycomb-Associated Non-Coding RNAs. AK300396 - Homo sapiens cDNA FLJ55035 complete cds, highly similar to Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor (EC 2.3.1.61). JD459289 - Sequence 440313 from Patent EP1572962. CU674146 - Synthetic construct Homo sapiens gateway clone IMAGE:100017302 5' read DLST mRNA. BX248774 - human full-length cDNA 5-PRIME end of clone CS0DJ009YL13 of T cells (Jurkat cell line) of Homo sapiens (human). LF330076 - JP 2014500723-A/137579: Polycomb-Associated Non-Coding RNAs. D17297 - Homo sapiens premature mRNA for dihydrolipoamide succinyltransferase, partial cds. LF330077 - JP 2014500723-A/137580: Polycomb-Associated Non-Coding RNAs. LF330078 - JP 2014500723-A/137581: Polycomb-Associated Non-Coding RNAs. DQ601636 - Homo sapiens piRNA piR-39702, complete sequence. MA565653 - JP 2018138019-A/137579: Polycomb-Associated Non-Coding RNAs. MA565654 - JP 2018138019-A/137580: Polycomb-Associated Non-Coding RNAs. MA565655 - JP 2018138019-A/137581: Polycomb-Associated Non-Coding RNAs. LF330082 - JP 2014500723-A/137585: Polycomb-Associated Non-Coding RNAs. LF330084 - JP 2014500723-A/137587: Polycomb-Associated Non-Coding RNAs. JD154608 - Sequence 135632 from Patent EP1572962. JD385130 - Sequence 366154 from Patent EP1572962. JD396144 - Sequence 377168 from Patent EP1572962. LF330085 - JP 2014500723-A/137588: Polycomb-Associated Non-Coding RNAs. JD318073 - Sequence 299097 from Patent EP1572962. JD131303 - Sequence 112327 from Patent EP1572962. JD361231 - Sequence 342255 from Patent EP1572962. JD433289 - Sequence 414313 from Patent EP1572962. JD196643 - Sequence 177667 from Patent EP1572962. JD341685 - Sequence 322709 from Patent EP1572962. JD113295 - Sequence 94319 from Patent EP1572962. JD110777 - Sequence 91801 from Patent EP1572962. JD083917 - Sequence 64941 from Patent EP1572962. JD557215 - Sequence 538239 from Patent EP1572962. JD331209 - Sequence 312233 from Patent EP1572962. JD326676 - Sequence 307700 from Patent EP1572962. JD449567 - Sequence 430591 from Patent EP1572962. JD361559 - Sequence 342583 from Patent EP1572962. JD248227 - Sequence 229251 from Patent EP1572962. JD557255 - Sequence 538279 from Patent EP1572962. JD273582 - Sequence 254606 from Patent EP1572962. JD558113 - Sequence 539137 from Patent EP1572962. JD429912 - Sequence 410936 from Patent EP1572962. JD411659 - Sequence 392683 from Patent EP1572962. JD554191 - Sequence 535215 from Patent EP1572962. JD233386 - Sequence 214410 from Patent EP1572962. JD474427 - Sequence 455451 from Patent EP1572962. JD076077 - Sequence 57101 from Patent EP1572962. LF330086 - JP 2014500723-A/137589: Polycomb-Associated Non-Coding RNAs. JD312771 - Sequence 293795 from Patent EP1572962. JD261340 - Sequence 242364 from Patent EP1572962. LF330087 - JP 2014500723-A/137590: Polycomb-Associated Non-Coding RNAs. JD234269 - Sequence 215293 from Patent EP1572962. JD358147 - Sequence 339171 from Patent EP1572962. LF330088 - JP 2014500723-A/137591: Polycomb-Associated Non-Coding RNAs. LF330089 - JP 2014500723-A/137592: Polycomb-Associated Non-Coding RNAs. MA565659 - JP 2018138019-A/137585: Polycomb-Associated Non-Coding RNAs. MA565661 - JP 2018138019-A/137587: Polycomb-Associated Non-Coding RNAs. MA565662 - JP 2018138019-A/137588: Polycomb-Associated Non-Coding RNAs. MA565663 - JP 2018138019-A/137589: Polycomb-Associated Non-Coding RNAs. MA565664 - JP 2018138019-A/137590: Polycomb-Associated Non-Coding RNAs. MA565665 - JP 2018138019-A/137591: Polycomb-Associated Non-Coding RNAs. MA565666 - JP 2018138019-A/137592: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
BioCyc Knowledge Library PWY-5084 - 2-oxoglutarate decarboxylation to succinyl-CoA PWY66-398 - TCA cycle PWY66-407 - superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle
Reactome (by CSHL, EBI, and GO)
Protein P36957 (Reactome details) participates in the following event(s):
R-HSA-6792572 LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs R-HSA-71037 alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ R-HSA-71401 alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ R-HSA-389661 Glyoxylate metabolism and glycine degradation R-HSA-71064 Lysine catabolism R-HSA-71403 Citric acid cycle (TCA cycle) R-HSA-71291 Metabolism of nitrogenous molecules R-HSA-6788656 Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle R-HSA-1430728 Metabolism R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
