Human Gene DNAH3 (ENST00000698260.1_5) from GENCODE V47lift37
  Description: dynein axonemal heavy chain 3, transcript variant 2 (from RefSeq NM_001347886.2)
Gencode Transcript: ENST00000698260.1_5
Gencode Gene: ENSG00000158486.15_13
Transcript (Including UTRs)
   Position: hg19 chr16:20,944,433-21,162,167 Size: 217,735 Total Exon Count: 62 Strand: -
Coding Region
   Position: hg19 chr16:20,944,476-21,161,640 Size: 217,165 Coding Exon Count: 61 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
Microarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:20,944,433-21,162,167)mRNA (may differ from genome)Protein (4070 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: DNAH3
Diseases sorted by gene-association score: cecal disease (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -81.80311-0.263 Picture PostScript Text
3' UTR -4.3043-0.100 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details  Gene Details  
Gene Sorter  Gene Sorter  
  Ensembl   
      
      

-  Descriptions from all associated GenBank mRNAs
  AL096732 - Homo sapiens mRNA; cDNA DKFZp434N074 (from clone DKFZp434N074).
AK125952 - Homo sapiens cDNA FLJ43964 fis, clone TESTI4016925, weakly similar to Dynein beta chain, ciliary.
AF494040 - Homo sapiens axonemal heavy chain dynein type 3 (DNAH3) mRNA, complete cds.
BC172185 - Synthetic construct Homo sapiens clone IMAGE:9094270 dynein, axonemal, heavy chain 3 (DNAH3) gene, partial cds.
BC172183 - Synthetic construct Homo sapiens clone IMAGE:9094268 dynein, axonemal, heavy chain 3 (DNAH3) gene, partial cds.
DQ574345 - Homo sapiens piRNA piR-42457, complete sequence.
BC172184 - Synthetic construct Homo sapiens clone IMAGE:9094269 dynein, axonemal, heavy chain 3 (DNAH3) gene, partial cds.
DQ597561 - Homo sapiens piRNA piR-35627, complete sequence.
AK125907 - Homo sapiens cDNA FLJ43919 fis, clone TESTI4011956, weakly similar to Ciliary dynein heavy chain.
BC019878 - Homo sapiens dynein, axonemal, heavy chain 3, mRNA (cDNA clone IMAGE:3864164), partial cds.
EU668352 - Homo sapiens epididymis luminal protein 36 (HEL-36) mRNA, complete cds.
Z83805 - H.sapiens mRNA for axonemal dynein heavy chain (partial, ID hdhc8).
AJ132085 - Homo sapiens mRNA for axonemal dynein heavy chain (DNAH3), partial.
BC172182 - Synthetic construct Homo sapiens clone IMAGE:9094267 dynein, axonemal, heavy chain 3 (DNAH3) gene, partial cds.
AK056509 - Homo sapiens cDNA FLJ31947 fis, clone NT2RP7006995, highly similar to Homo sapiens dynein, axonemal, heavy polypeptide 3 (DNAH3).
AK303958 - Homo sapiens cDNA FLJ53270 complete cds, moderately similar to Homo sapiens dynein, axonemal, heavy polypeptide 3 (DNAH3), mRNA.
AK026793 - Homo sapiens cDNA: FLJ23140 fis, clone LNG09065.
JD423862 - Sequence 404886 from Patent EP1572962.
AK310973 - Homo sapiens cDNA, FLJ18015.
JD385829 - Sequence 366853 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_Lis1Pathway - Lissencephaly gene (LIS1) in neuronal migration and development

-  Other Names for This Gene
  Alternate Gene Symbols: A0A8V8TLI9, A0A8V8TLI9_HUMAN, DNAH3 , NM_001347886, uc331djl.1, uc331djl.2
UCSC ID: ENST00000698260.1_5
RefSeq Accession: NM_001347886.2

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.