ID:DYH6_HUMAN DESCRIPTION: RecName: Full=Dynein heavy chain 6, axonemal; AltName: Full=Axonemal beta dynein heavy chain 6; AltName: Full=Ciliary dynein heavy chain 6; FUNCTION: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). SUBUNIT: The dynein complex consists of at least two heavy chains and a number of intermediate and light chains (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme (By similarity). TISSUE SPECIFICITY: Detected in brain, testis and trachea. DOMAIN: Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly- linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity). SIMILARITY: Belongs to the dynein heavy chain family. SEQUENCE CAUTION: Sequence=AAH15442.1; Type=Erroneous initiation; Sequence=AAX93115.1; Type=Erroneous gene model prediction; Sequence=BAB15685.1; Type=Frameshift; Positions=3690;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF03028 - Dynein heavy chain region D6 P-loop domain PF07728 - AAA domain (dynein-related subfamily) PF08393 - Dynein heavy chain, N-terminal region 2 PF12774 - Hydrolytic ATP binding site of dynein motor region PF12775 - P-loop containing dynein motor region PF12777 - Microtubule-binding stalk of dynein motor PF12780 - P-loop containing dynein motor region D4 PF12781 - ATP-binding dynein motor region PF17852 - Dynein heavy chain AAA lid domain PF17857 - AAA+ lid domain PF18198 - Dynein heavy chain AAA lid domain PF18199 - Dynein heavy chain C-terminal domain
SCOP Domains: 46894 - C-terminal effector domain of the bipartite response regulators 52540 - P-loop containing nucleoside triphosphate hydrolases 53795 - PEP carboxykinase-like
ModBase Predicted Comparative 3D Structure on Q9C0G6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
