Human Gene DNAJA2 (ENST00000317089.10_7) from GENCODE V47lift37
  Description: DnaJ heat shock protein family (Hsp40) member A2 (from RefSeq NM_005880.4)
Gencode Transcript: ENST00000317089.10_7
Gencode Gene: ENSG00000069345.12_10
Transcript (Including UTRs)
   Position: hg19 chr16:46,989,274-47,007,585 Size: 18,312 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr16:46,990,941-47,007,483 Size: 16,543 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:46,989,274-47,007,585)mRNA (may differ from genome)Protein (412 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: DNJA2_HUMAN
DESCRIPTION: RecName: Full=DnaJ homolog subfamily A member 2; AltName: Full=Cell cycle progression restoration gene 3 protein; AltName: Full=Dnj3; Short=Dj3; AltName: Full=HIRA-interacting protein 4; AltName: Full=Renal carcinoma antigen NY-REN-14; Flags: Precursor;
FUNCTION: Co-chaperone of Hsc70.
SUBCELLULAR LOCATION: Membrane; Lipid-anchor (Potential).
SIMILARITY: Contains 1 CR-type zinc finger.
SIMILARITY: Contains 1 J domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: DNAJA2
Diseases sorted by gene-association score: subacute bacterial endocarditis (16)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 24.43 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 824.78 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -29.80102-0.292 Picture PostScript Text
3' UTR -386.901667-0.232 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012724 - DnaJ
IPR002939 - DnaJ_C
IPR001623 - DnaJ_N
IPR018253 - Heat_shock_DnaJ_CS
IPR008971 - HSP40/DnaJ_pept-bd
IPR003095 - Hsp_DnaJ
IPR001305 - HSP_DnaJ_Cys-rich_dom

Pfam Domains:
PF00226 - DnaJ domain
PF00684 - DnaJ central domain
PF01556 - DnaJ C terminal domain

SCOP Domains:
48695 - Multiheme cytochromes
46565 - Chaperone J-domain
49493 - HSP40/DnaJ peptide-binding domain
57938 - DnaJ/Hsp40 cysteine-rich domain

ModBase Predicted Comparative 3D Structure on O60884
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
Gene DetailsGene Details  Gene DetailsGene Details
Gene SorterGene Sorter  Gene SorterGene Sorter
 RGDEnsembl WormBaseSGD
    Protein SequenceProtein Sequence
    AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001671 ATPase activator activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0031072 heat shock protein binding
GO:0046872 metal ion binding
GO:0051082 unfolded protein binding
GO:0051087 chaperone binding

Biological Process:
GO:0006457 protein folding
GO:0008284 positive regulation of cell proliferation
GO:0009408 response to heat
GO:0032781 positive regulation of ATPase activity
GO:0042026 protein refolding

Cellular Component:
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  BC015809 - Homo sapiens DnaJ (Hsp40) homolog, subfamily A, member 2, mRNA (cDNA clone MGC:9488 IMAGE:3922477), complete cds.
Y13350 - Homo sapiens mRNA for DnaJ protein.
AJ001309 - Homo sapiens mRNA for DnaJ protein.
JD450756 - Sequence 431780 from Patent EP1572962.
AF088046 - Homo sapiens full length insert cDNA clone ZD59G03.
AF011793 - Homo sapiens DNJ3/CPR3 mRNA, complete cds.
JD306031 - Sequence 287055 from Patent EP1572962.
JD067958 - Sequence 48982 from Patent EP1572962.
BC013044 - Homo sapiens DnaJ (Hsp40) homolog, subfamily A, member 2, mRNA (cDNA clone MGC:819 IMAGE:3505399), complete cds.
JD311070 - Sequence 292094 from Patent EP1572962.
AK313031 - Homo sapiens cDNA, FLJ93502, Homo sapiens DnaJ (Hsp40) homolog, subfamily A, member 2 (DNAJA2),mRNA.
HQ448279 - Synthetic construct Homo sapiens clone IMAGE:100071682; CCSB000306_01 DnaJ (Hsp40) homolog, subfamily A, member 2 (DNAJA2) gene, encodes complete protein.
KJ892996 - Synthetic construct Homo sapiens clone ccsbBroadEn_02390 DNAJA2 gene, encodes complete protein.
CU677459 - Synthetic construct Homo sapiens gateway clone IMAGE:100017209 5' read DNAJA2 mRNA.
JD189572 - Sequence 170596 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O60884 (Reactome details) participates in the following event(s):

R-HSA-3371503 STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein
R-HSA-3371422 ATP hydrolysis by HSP70
R-HSA-3371590 HSP70 binds to HSP40:nascent protein
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-2262752 Cellular responses to stress
R-HSA-8953897 Cellular responses to external stimuli

-  Other Names for This Gene
  Alternate Gene Symbols: B2R7L7, CPR3, DNJA2_HUMAN, ENST00000317089.1, ENST00000317089.2, ENST00000317089.3, ENST00000317089.4, ENST00000317089.5, ENST00000317089.6, ENST00000317089.7, ENST00000317089.8, ENST00000317089.9, HIRIP4, NM_005880, O14711, O60884, uc317qdu.1, uc317qdu.2
UCSC ID: ENST00000317089.10_7
RefSeq Accession: NM_005880.4
Protein: O60884 (aka DNJA2_HUMAN or DJA2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.