Human Gene DNAJB1 (ENST00000254322.3_7) from GENCODE V47lift37
  Description: DnaJ heat shock protein family (Hsp40) member B1, transcript variant 1 (from RefSeq NM_006145.3)
Gencode Transcript: ENST00000254322.3_7
Gencode Gene: ENSG00000132002.10_13
Transcript (Including UTRs)
   Position: hg19 chr19:14,625,581-14,629,209 Size: 3,629 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr19:14,626,752-14,629,161 Size: 2,410 Coding Exon Count: 3 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:14,625,581-14,629,209)mRNA (may differ from genome)Protein (340 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: DNAJB1
Diseases sorted by gene-association score: fibrolamellar carcinoma* (253), antenatal bartter syndrome (2)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 165.54 RPKM in Esophagus - Mucosa
Total median expression: 2133.64 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -17.4048-0.362 Picture PostScript Text
3' UTR -393.001171-0.336 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002939 - DnaJ_C
IPR001623 - DnaJ_N
IPR018253 - Heat_shock_DnaJ_CS
IPR008971 - HSP40/DnaJ_pept-bd
IPR003095 - Hsp_DnaJ

Pfam Domains:
PF00226 - DnaJ domain
PF01556 - DnaJ C terminal domain

SCOP Domains:
46565 - Chaperone J-domain
49493 - HSP40/DnaJ peptide-binding domain

ModBase Predicted Comparative 3D Structure on Q6FHS4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0051082 unfolded protein binding

Biological Process:
GO:0006457 protein folding
GO:0030900 forebrain development
GO:0051085 chaperone mediated protein folding requiring cofactor

Cellular Component:
GO:0005634 nucleus
GO:0043025 neuronal cell body
GO:0043197 dendritic spine


-  Descriptions from all associated GenBank mRNAs
  BC002352 - Homo sapiens DnaJ (Hsp40) homolog, subfamily B, member 1, mRNA (cDNA clone MGC:8425 IMAGE:2821008), complete cds.
BC013157 - Homo sapiens cDNA clone IMAGE:3919249, containing frame-shift errors.
AK092989 - Homo sapiens cDNA FLJ35670 fis, clone SPLEN2018159, moderately similar to HEAT SHOCK 40 KDA PROTEIN 1.
D49547 - Homo sapiens hsp40 mRNA for heat-shock protein 40, complete cds.
JD087677 - Sequence 68701 from Patent EP1572962.
JD379793 - Sequence 360817 from Patent EP1572962.
JD563385 - Sequence 544409 from Patent EP1572962.
JD548513 - Sequence 529537 from Patent EP1572962.
JD049225 - Sequence 30249 from Patent EP1572962.
JD181482 - Sequence 162506 from Patent EP1572962.
JD342837 - Sequence 323861 from Patent EP1572962.
JD315071 - Sequence 296095 from Patent EP1572962.
JD547195 - Sequence 528219 from Patent EP1572962.
JD378540 - Sequence 359564 from Patent EP1572962.
JD561647 - Sequence 542671 from Patent EP1572962.
AK296609 - Homo sapiens cDNA FLJ52967 complete cds, highly similar to DnaJ homolog subfamily B member 1.
JD425008 - Sequence 406032 from Patent EP1572962.
JD116265 - Sequence 97289 from Patent EP1572962.
X62421 - Homo sapiens mRNA for DnaJ protein homologue.
JD527518 - Sequence 508542 from Patent EP1572962.
JD355991 - Sequence 337015 from Patent EP1572962.
AK301817 - Homo sapiens cDNA FLJ59093 complete cds, highly similar to DnaJ homolog subfamily B member 1.
JD488359 - Sequence 469383 from Patent EP1572962.
JD493915 - Sequence 474939 from Patent EP1572962.
LF208170 - JP 2014500723-A/15673: Polycomb-Associated Non-Coding RNAs.
BC019827 - Homo sapiens DnaJ (Hsp40) homolog, subfamily B, member 1, mRNA (cDNA clone MGC:29935 IMAGE:4152608), complete cds.
JD386399 - Sequence 367423 from Patent EP1572962.
JD526527 - Sequence 507551 from Patent EP1572962.
DL491965 - Novel nucleic acids.
DL490522 - Novel nucleic acids.
JD252908 - Sequence 233932 from Patent EP1572962.
KJ891407 - Synthetic construct Homo sapiens clone ccsbBroadEn_00801 DNAJB1 gene, encodes complete protein.
CR536485 - Homo sapiens full open reading frame cDNA clone RZPDo834C0320D for gene DNAJB1, DnaJ (Hsp40) homolog, subfamily B, member 1; complete cds, incl. stopcodon.
AK312624 - Homo sapiens cDNA, FLJ93008, Homo sapiens DnaJ (Hsp40) homolog, subfamily B, member 1 (DNAJB1),mRNA.
CR541677 - Homo sapiens full open reading frame cDNA clone RZPDo834C0428D for gene DNAJB1, DnaJ (Hsp40) homolog, subfamily B, member 1; complete cds, without stopcodon.
AB463573 - Synthetic construct DNA, clone: pF1KB5377, Homo sapiens DNAJB1 gene for DnaJ (Hsp40) homolog, subfamily B, member 1, without stop codon, in Flexi system.
CU676466 - Synthetic construct Homo sapiens gateway clone IMAGE:100018148 5' read DNAJB1 mRNA.
LF373210 - JP 2014500723-A/180713: Polycomb-Associated Non-Coding RNAs.
MA608787 - JP 2018138019-A/180713: Polycomb-Associated Non-Coding RNAs.
MA443747 - JP 2018138019-A/15673: Polycomb-Associated Non-Coding RNAs.
MP015449 - Sequence 652 from Patent WO2019016252.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_prionPathway - Prion Pathway
h_p53hypoxiaPathway - Hypoxia and p53 in the Cardiovascular system

-  Other Names for This Gene
  Alternate Gene Symbols: DNAJB1 , ENST00000254322.1, ENST00000254322.2, hCG_1776318 , NM_006145, Q6FHS4, Q6FHS4_HUMAN, uc317fob.1, uc317fob.2
UCSC ID: ENST00000254322.3_7
RefSeq Accession: NM_006145.3
Protein: Q6FHS4

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.