Human Gene DNAJC28 (ENST00000314399.3_4) from GENCODE V47lift37
  Description: DnaJ heat shock protein family (Hsp40) member C28, transcript variant 1 (from RefSeq NM_017833.5)
Gencode Transcript: ENST00000314399.3_4
Gencode Gene: ENSG00000177692.13_9
Transcript (Including UTRs)
   Position: hg19 chr21:34,860,515-34,863,780 Size: 3,266 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr21:34,860,534-34,861,700 Size: 1,167 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr21:34,860,515-34,863,780)mRNA (may differ from genome)Protein (388 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: DJC28_HUMAN
DESCRIPTION: RecName: Full=DnaJ homolog subfamily C member 28;
FUNCTION: May have a role in protein folding or as a chaperone.
TISSUE SPECIFICITY: Expressed in the fetal and adult brain, testis, uterus, spleen and liver.
DEVELOPMENTAL STAGE: Not expressed in 8 and 10 weeks old fetuses.
SIMILARITY: Contains 1 J domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: DNAJC28
Diseases sorted by gene-association score: retinitis pigmentosa 4, autosomal dominant or recessive (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.59 RPKM in Testis
Total median expression: 39.48 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -140.00439-0.319 Picture PostScript Text
3' UTR 0.00190.000 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018961 - DnaJ_homolog_subfam-C_membr-28
IPR001623 - DnaJ_N

Pfam Domains:
PF00226 - DnaJ domain
PF09350 - Domain of unknown function (DUF1992)

SCOP Domains:
46565 - Chaperone J-domain

ModBase Predicted Comparative 3D Structure on Q9NX36
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0000301 retrograde transport, vesicle recycling within Golgi
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER
GO:0007030 Golgi organization
GO:0048213 Golgi vesicle prefusion complex stabilization

Cellular Component:
GO:0017119 Golgi transport complex


-  Descriptions from all associated GenBank mRNAs
  AF462153 - Homo sapiens C21orf55 protein (C21orf55) mRNA, complete cds.
BC029509 - Homo sapiens chromosome 21 open reading frame 55, mRNA (cDNA clone IMAGE:5299220), containing frame-shift errors.
AK000468 - Homo sapiens cDNA FLJ20461 fis, clone KAT06105.
AK225514 - Homo sapiens mRNA for hypothetical protein LOC54943 variant, clone: KAT06105.
BC156694 - Synthetic construct Homo sapiens clone IMAGE:100062193, MGC:190197 DnaJ (Hsp40) homolog, subfamily C, member 28 (DNAJC28) mRNA, encodes complete protein.
JD291972 - Sequence 272996 from Patent EP1572962.
JD439205 - Sequence 420229 from Patent EP1572962.
KJ902723 - Synthetic construct Homo sapiens clone ccsbBroadEn_12117 DNAJC28 gene, encodes complete protein.
JD311358 - Sequence 292382 from Patent EP1572962.
JD069355 - Sequence 50379 from Patent EP1572962.
JD172915 - Sequence 153939 from Patent EP1572962.
JD372727 - Sequence 353751 from Patent EP1572962.
JD217708 - Sequence 198732 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: C21orf55, C21orf78, D3DSF2, DJC28_HUMAN, ENST00000314399.1, ENST00000314399.2, NM_017833, Q9NX36, uc317ppt.1
UCSC ID: ENST00000314399.3_4
RefSeq Accession: NM_017833.5
Protein: Q9NX36 (aka DJC28_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.