ID:DNJC3_HUMAN DESCRIPTION: RecName: Full=DnaJ homolog subfamily C member 3; AltName: Full=Endoplasmic reticulum DnaJ protein 6; Short=ERdj6; AltName: Full=Interferon-induced, double-stranded RNA-activated protein kinase inhibitor; AltName: Full=Protein kinase inhibitor of 58 kDa; Short=Protein kinase inhibitor p58; Flags: Precursor; FUNCTION: Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. SUBUNIT: Interacts with EIF2AK3 (By similarity) and EIF2AK2. Forms a trimeric complex with DNAJB1 and HSPA8. Interacts with PRKRIR/P52RIPK. SUBCELLULAR LOCATION: Endoplasmic reticulum (By similarity). TISSUE SPECIFICITY: Widely expressed with high level in the pancreas and testis. Also expressed in cell lines with different levels. INDUCTION: Up-regulated during an endoplasmic reticulum stress via ATF6. Activated in response to infection by influenza virus through the dissociation of DNAJB1. Down-regulated by DNAJB1 and PRKRIR/P52RIPK. DOMAIN: The J domain mediates interaction with HSPA8. DOMAIN: Binding to misfolded proteins is mediated by a hydrophobic patch forming a large groove within the first two TPR repeats (By similarity). SIMILARITY: Contains 1 J domain. SIMILARITY: Contains 9 TPR repeats. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/dnajc3/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13217
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004860 protein kinase inhibitor activity GO:0019901 protein kinase binding GO:0051087 chaperone binding GO:0051787 misfolded protein binding
Biological Process: GO:0006417 regulation of translation GO:0006469 negative regulation of protein kinase activity GO:0006986 response to unfolded protein GO:0036494 positive regulation of translation initiation in response to endoplasmic reticulum stress GO:0036498 IRE1-mediated unfolded protein response GO:0043066 negative regulation of apoptotic process GO:0043312 neutrophil degranulation GO:0043687 post-translational protein modification GO:0044267 cellular protein metabolic process GO:0051603 proteolysis involved in cellular protein catabolic process GO:0051607 defense response to virus GO:0070417 cellular response to cold GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
