ID:DNJC7_HUMAN DESCRIPTION: RecName: Full=DnaJ homolog subfamily C member 7; AltName: Full=Tetratricopeptide repeat protein 2; Short=TPR repeat protein 2; FUNCTION: Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone- substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity). SUBUNIT: Associates with complexes containing chaperones HSP70 and HSP90. Interacts with the GAP domain of NF1. Interacts with HSP90AA1. Interacts with HSPA1A/B; the interaction is enhanced by ATP. Interacts with HSP90AB1. Interacts with PGR. Interacts with RAD9A; the interaction is interrupted by UV and heat shock treatments. Interacts with HUS1 and RAD1. Interacts with NR1I3. The DNAJC7-NR1I3 complex may also include HSP90 (By similarity). Interacts with HSPA8. INTERACTION: P12504:vif (xeno); NbExp=3; IntAct=EBI-357552, EBI-779991; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Note=Colocalizes with NR1I3 to microtubules (By similarity). SIMILARITY: Contains 1 J domain. SIMILARITY: Contains 9 TPR repeats. SEQUENCE CAUTION: Sequence=AAB36872.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH33772.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99615
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0001671 ATPase activator activity GO:0005515 protein binding GO:0031072 heat shock protein binding
Biological Process: GO:0006457 protein folding GO:0032781 positive regulation of ATPase activity GO:0051085 chaperone mediated protein folding requiring cofactor GO:1900034 regulation of cellular response to heat
LF384801 - JP 2014500723-A/192304: Polycomb-Associated Non-Coding RNAs. BC003601 - Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 7, mRNA (cDNA clone MGC:911 IMAGE:3543074), complete cds. BX647209 - Homo sapiens mRNA; cDNA DKFZp686I18256 (from clone DKFZp686I18256). BC011837 - Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 7, mRNA (cDNA clone MGC:20075 IMAGE:3945721), complete cds. AB209834 - Homo sapiens mRNA for DnaJ (Hsp40) homolog, subfamily C, member 7 variant protein. U46571 - Human tetratricopeptide repeat protein (tpr2) mRNA, complete cds. AK291047 - Homo sapiens cDNA FLJ76281 complete cds, highly similar to Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 7 (DNAJC7), mRNA. BC033772 - Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 7, mRNA (cDNA clone MGC:45296 IMAGE:3924081), complete cds. AK298860 - Homo sapiens cDNA FLJ51941 complete cds, highly similar to DnaJ homolog subfamily C member 7. JD472149 - Sequence 453173 from Patent EP1572962. JD484125 - Sequence 465149 from Patent EP1572962. JD077160 - Sequence 58184 from Patent EP1572962. LF327796 - JP 2014500723-A/135299: Polycomb-Associated Non-Coding RNAs. JD329473 - Sequence 310497 from Patent EP1572962. AK296602 - Homo sapiens cDNA FLJ54791 complete cds, highly similar to DnaJ homolog subfamily C member 7. JD429390 - Sequence 410414 from Patent EP1572962. JD202697 - Sequence 183721 from Patent EP1572962. AK316081 - Homo sapiens cDNA, FLJ78980 complete cds, highly similar to DnaJ homolog subfamily C member 7. JD040791 - Sequence 21815 from Patent EP1572962. LF327797 - JP 2014500723-A/135300: Polycomb-Associated Non-Coding RNAs. KJ892328 - Synthetic construct Homo sapiens clone ccsbBroadEn_01722 DNAJC7 gene, encodes complete protein. DQ893064 - Synthetic construct clone IMAGE:100005694; FLH193230.01X; RZPDo839E0178D DnaJ (Hsp40) homolog, subfamily C, member 7 (DNAJC7) gene, encodes complete protein. KJ901813 - Synthetic construct Homo sapiens clone ccsbBroadEn_11207 DNAJC7 gene, encodes complete protein. KJ892327 - Synthetic construct Homo sapiens clone ccsbBroadEn_01721 DNAJC7 gene, encodes complete protein. DQ896317 - Synthetic construct Homo sapiens clone IMAGE:100010777; FLH193226.01L; RZPDo839E0168D DnaJ (Hsp40) homolog, subfamily C, member 7 (DNAJC7) gene, encodes complete protein. AB587519 - Synthetic construct DNA, clone: pF1KE0031, Homo sapiens DNAJC7 gene for DnaJ (Hsp40) homolog, subfamily C, member 7, without stop codon, in Flexi system. AM393511 - Synthetic construct Homo sapiens clone IMAGE:100002500 for hypothetical protein (DNAJC7 gene). LF327799 - JP 2014500723-A/135302: Polycomb-Associated Non-Coding RNAs. LF327800 - JP 2014500723-A/135303: Polycomb-Associated Non-Coding RNAs. LF327801 - JP 2014500723-A/135304: Polycomb-Associated Non-Coding RNAs. CU678526 - Synthetic construct Homo sapiens gateway clone IMAGE:100022474 5' read DNAJC7 mRNA. LF327802 - JP 2014500723-A/135305: Polycomb-Associated Non-Coding RNAs. AK308016 - Homo sapiens cDNA, FLJ97964. LF327803 - JP 2014500723-A/135306: Polycomb-Associated Non-Coding RNAs. LF327804 - JP 2014500723-A/135307: Polycomb-Associated Non-Coding RNAs. CU680076 - Synthetic construct Homo sapiens gateway clone IMAGE:100019667 5' read DNAJC7 mRNA. CU689734 - Synthetic construct Homo sapiens gateway clone IMAGE:100019617 5' read DNAJC7 mRNA. JD022912 - Sequence 3936 from Patent EP1572962. JD027821 - Sequence 8845 from Patent EP1572962. LF327816 - JP 2014500723-A/135319: Polycomb-Associated Non-Coding RNAs. MA620378 - JP 2018138019-A/192304: Polycomb-Associated Non-Coding RNAs. MA563373 - JP 2018138019-A/135299: Polycomb-Associated Non-Coding RNAs. MA563374 - JP 2018138019-A/135300: Polycomb-Associated Non-Coding RNAs. MA563376 - JP 2018138019-A/135302: Polycomb-Associated Non-Coding RNAs. MA563377 - JP 2018138019-A/135303: Polycomb-Associated Non-Coding RNAs. MA563378 - JP 2018138019-A/135304: Polycomb-Associated Non-Coding RNAs. MA563379 - JP 2018138019-A/135305: Polycomb-Associated Non-Coding RNAs. MA563380 - JP 2018138019-A/135306: Polycomb-Associated Non-Coding RNAs. MA563381 - JP 2018138019-A/135307: Polycomb-Associated Non-Coding RNAs. MA563393 - JP 2018138019-A/135319: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q99615 (Reactome details) participates in the following event(s):
R-HSA-5251959 HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol R-HSA-5251955 HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm R-HSA-3371453 Regulation of HSF1-mediated heat shock response R-HSA-3371556 Cellular response to heat stress R-HSA-2262752 Cellular responses to stress R-HSA-8953897 Cellular responses to external stimuli
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
