Human Gene DNHD1 (ENST00000254579.11_6) from GENCODE V47lift37
  Description: dynein heavy chain domain 1, transcript variant 1 (from RefSeq NM_144666.3)
Gencode Transcript: ENST00000254579.11_6
Gencode Gene: ENSG00000179532.13_13
Transcript (Including UTRs)
   Position: hg19 chr11:6,518,510-6,593,250 Size: 74,741 Total Exon Count: 43 Strand: +
Coding Region
   Position: hg19 chr11:6,519,446-6,593,216 Size: 73,771 Coding Exon Count: 41 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:6,518,510-6,593,250)mRNA (may differ from genome)Protein (4753 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: DNHD1_HUMAN
DESCRIPTION: RecName: Full=Dynein heavy chain domain-containing protein 1; AltName: Full=Dynein heavy chain domain 1-like protein; AltName: Full=Protein CCDC35;
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: Belongs to the dynein heavy chain family.
SEQUENCE CAUTION: Sequence=AAQ89130.1; Type=Frameshift; Positions=637; Sequence=BAB85004.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=CAB70845.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=EAW68692.1; Type=Erroneous gene model prediction;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 21.15 RPKM in Testis
Total median expression: 117.04 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -236.20580-0.407 Picture PostScript Text
3' UTR -1.3034-0.038 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026983 - DHC_fam
IPR024743 - Dynein_HC_stalk
IPR004273 - Dynein_heavy_dom
IPR013602 - Dynein_heavy_dom-2

Pfam Domains:
PF03028 - Dynein heavy chain region D6 P-loop domain
PF08393 - Dynein heavy chain, N-terminal region 2
PF12774 - Hydrolytic ATP binding site of dynein motor region
PF12775 - P-loop containing dynein motor region
PF12777 - Microtubule-binding stalk of dynein motor
PF12780 - P-loop containing dynein motor region D4
PF17852 - Dynein heavy chain AAA lid domain
PF18199 - Dynein heavy chain C-terminal domain

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases
53795 - PEP carboxykinase-like

ModBase Predicted Comparative 3D Structure on Q96M86
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed
GO:0045503 dynein light chain binding
GO:0045505 dynein intermediate chain binding
GO:0051959 dynein light intermediate chain binding

Biological Process:
GO:0003341 cilium movement
GO:0007018 microtubule-based movement
GO:0036159 inner dynein arm assembly

Cellular Component:
GO:0030286 dynein complex
GO:0036156 inner dynein arm
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  BX647806 - Homo sapiens mRNA; cDNA DKFZp686J0796 (from clone DKFZp686J0796).
AK096944 - Homo sapiens cDNA FLJ39625 fis, clone SMINT2001535.
JD043344 - Sequence 24368 from Patent EP1572962.
JD048369 - Sequence 29393 from Patent EP1572962.
BX648742 - Homo sapiens mRNA; cDNA DKFZp686N1238 (from clone DKFZp686N1238).
BC111765 - Homo sapiens dynein heavy chain domain 1, mRNA (cDNA clone IMAGE:40027908), complete cds.
KJ895573 - Synthetic construct Homo sapiens clone ccsbBroadEn_04967 DNHD1 gene, encodes complete protein.
JD528665 - Sequence 509689 from Patent EP1572962.
JD317623 - Sequence 298647 from Patent EP1572962.
JD106389 - Sequence 87413 from Patent EP1572962.
JD468351 - Sequence 449375 from Patent EP1572962.
JD214177 - Sequence 195201 from Patent EP1572962.
JD334877 - Sequence 315901 from Patent EP1572962.
AK093028 - Homo sapiens cDNA FLJ35709 fis, clone SPLEN2020512.
AX747866 - Sequence 1391 from Patent EP1308459.
JD535075 - Sequence 516099 from Patent EP1572962.
JD564252 - Sequence 545276 from Patent EP1572962.
AK074178 - Homo sapiens mRNA for FLJ00251 protein.
AB290171 - Homo sapiens mRNA for DNHD1 variant protein, partial cds.
JD525725 - Sequence 506749 from Patent EP1572962.
JD114319 - Sequence 95343 from Patent EP1572962.
JD312631 - Sequence 293655 from Patent EP1572962.
JD452333 - Sequence 433357 from Patent EP1572962.
JD100706 - Sequence 81730 from Patent EP1572962.
JD337176 - Sequence 318200 from Patent EP1572962.
JD399565 - Sequence 380589 from Patent EP1572962.
JD247241 - Sequence 228265 from Patent EP1572962.
JD475385 - Sequence 456409 from Patent EP1572962.
JD057472 - Sequence 38496 from Patent EP1572962.
AK125885 - Homo sapiens cDNA FLJ43897 fis, clone TESTI4009881, weakly similar to Dynein heavy chain, cytosolic (DYHC).
JD200523 - Sequence 181547 from Patent EP1572962.
JD079194 - Sequence 60218 from Patent EP1572962.
JD202260 - Sequence 183284 from Patent EP1572962.
JD560290 - Sequence 541314 from Patent EP1572962.
JD426583 - Sequence 407607 from Patent EP1572962.
JD274403 - Sequence 255427 from Patent EP1572962.
JD361958 - Sequence 342982 from Patent EP1572962.
JD187621 - Sequence 168645 from Patent EP1572962.
JD158188 - Sequence 139212 from Patent EP1572962.
AL137619 - Homo sapiens mRNA; cDNA DKFZp434G0812 (from clone DKFZp434G0812); partial cds.
JD307741 - Sequence 288765 from Patent EP1572962.
JD411582 - Sequence 392606 from Patent EP1572962.
JD187361 - Sequence 168385 from Patent EP1572962.
JD133721 - Sequence 114745 from Patent EP1572962.
JD313477 - Sequence 294501 from Patent EP1572962.
JD539864 - Sequence 520888 from Patent EP1572962.
JD334931 - Sequence 315955 from Patent EP1572962.
JD273090 - Sequence 254114 from Patent EP1572962.
JD335706 - Sequence 316730 from Patent EP1572962.
JD115028 - Sequence 96052 from Patent EP1572962.
JD358228 - Sequence 339252 from Patent EP1572962.
JD306495 - Sequence 287519 from Patent EP1572962.
JD261924 - Sequence 242948 from Patent EP1572962.
AB231770 - Homo sapiens mRNA for hypothetical protein, partial sequence, clone:Hsa11-digit31-01-04-R.
AB231768 - Homo sapiens mRNA for hypothetical protein, partial sequence, clone:Hsa11-digit31-01-03-R.
AB231778 - Homo sapiens mRNA for hypothetical protein, partial sequence, clone:Hsa11-digit31-01-12-R.
AB231774 - Homo sapiens mRNA for hypothetical protein, partial sequence, clone:Hsa11-digit31-01-08-R.
AB231776 - Homo sapiens mRNA for hypothetical protein, partial sequence, clone:Hsa11-digit31-01-11-R.
AB231771 - Homo sapiens mRNA for hypothetical protein, partial sequence, clone:Hsa11-digit31-01-05-F.
AB231777 - Homo sapiens mRNA for hypothetical protein, partial sequence, clone:Hsa11-digit31-01-12-F.
AB231769 - Homo sapiens mRNA for hypothetical protein, partial sequence, clone:Hsa11-digit31-01-04-F.
AB231772 - Homo sapiens mRNA for hypothetical protein, partial sequence, clone:Hsa11-digit31-01-05-R.
AB231773 - Homo sapiens mRNA for hypothetical protein, partial sequence, clone:Hsa11-digit31-01-08-F.
AB231767 - Homo sapiens mRNA for hypothetical protein, partial sequence, clone:Hsa11-digit31-01-03-F.
AB231775 - Homo sapiens mRNA for hypothetical protein, partial sequence, clone:Hsa11-digit31-01-11-F.
AK128064 - Homo sapiens cDNA FLJ46184 fis, clone TESTI4004695.
AL834222 - Homo sapiens mRNA; cDNA DKFZp434K2212 (from clone DKFZp434K2212).
BC067363 - Homo sapiens dynein heavy chain domain 1, mRNA (cDNA clone IMAGE:6671688), with apparent retained intron.
BC082757 - Homo sapiens dynein heavy chain domain 1, mRNA (cDNA clone IMAGE:6585131).
AK057314 - Homo sapiens cDNA FLJ32752 fis, clone TESTI2001661, weakly similar to DYNEIN BETA CHAIN, FLAGELLAR OUTER ARM.
JD536754 - Sequence 517778 from Patent EP1572962.
JD549175 - Sequence 530199 from Patent EP1572962.
JD444620 - Sequence 425644 from Patent EP1572962.
JD466652 - Sequence 447676 from Patent EP1572962.
BC117301 - Homo sapiens dynein heavy chain domain 1, mRNA (cDNA clone IMAGE:40125852), complete cds.
BC117303 - Homo sapiens dynein heavy chain domain 1, mRNA (cDNA clone IMAGE:40125854), complete cds.
BC143910 - Homo sapiens cDNA clone IMAGE:9052428.
JD363421 - Sequence 344445 from Patent EP1572962.
JD374164 - Sequence 355188 from Patent EP1572962.
JD281025 - Sequence 262049 from Patent EP1572962.
JD524611 - Sequence 505635 from Patent EP1572962.
AL137690 - Homo sapiens mRNA; cDNA DKFZp434O032 (from clone DKFZp434O032).
AY358770 - Homo sapiens clone DNA129594 PVFW5781 (UNQ5781) mRNA, complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: C11orf47, CCDC35 , DHCD1, DNHD1L, DNHD1_HUMAN, ENST00000254579.1, ENST00000254579.10, ENST00000254579.2, ENST00000254579.3, ENST00000254579.4, ENST00000254579.5, ENST00000254579.6, ENST00000254579.7, ENST00000254579.8, ENST00000254579.9, NM_144666, Q2NKK8, Q6UWI9, Q8NAA2, Q8TEE6, Q96M86, Q9NSZ9, uc317fon.1, uc317fon.2, UNQ5781/PRO12970
UCSC ID: ENST00000254579.11_6
RefSeq Accession: NM_144666.3
Protein: Q96M86 (aka DNHD1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.