Human Gene DNTTIP1 (ENST00000372622.8_4) from GENCODE V47lift37
  Description: deoxynucleotidyltransferase terminal interacting protein 1 (from RefSeq NM_052951.3)
Gencode Transcript: ENST00000372622.8_4
Gencode Gene: ENSG00000101457.13_11
Transcript (Including UTRs)
   Position: hg19 chr20:44,420,593-44,440,057 Size: 19,465 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg19 chr20:44,420,644-44,439,834 Size: 19,191 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr20:44,420,593-44,440,057)mRNA (may differ from genome)Protein (329 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TDIF1_HUMAN
DESCRIPTION: RecName: Full=Deoxynucleotidyltransferase terminal-interacting protein 1; AltName: Full=Terminal deoxynucleotidyltransferase-interacting factor 1; Short=TdIF1; Short=TdT-interacting factor 1;
FUNCTION: Shown to enhance TdT activity, in vitro.
SUBUNIT: Monomer, homodimer and homotrimer. Interacts with terminal deoxynucleotidyltransferase (TdT).
SUBCELLULAR LOCATION: Nucleus.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 27.99 RPKM in Testis
Total median expression: 684.02 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -19.8051-0.388 Picture PostScript Text
3' UTR -71.90223-0.322 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026064 - TdIF1

Pfam Domains:
PF18192 - DNTTIP1 dimerisation domain

ModBase Predicted Comparative 3D Structure on Q9H147
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0031491 nucleosome binding
GO:0042803 protein homodimerization activity

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated

Cellular Component:
GO:0000118 histone deacetylase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus


-  Descriptions from all associated GenBank mRNAs
  AB035676 - Homo sapiens mRNA for TdT binding protein, complete cds.
AK314003 - Homo sapiens cDNA, FLJ94657, Homo sapiens deoxynucleotidyltransferase, terminal, interactingprotein 1 (DNTTIP1), mRNA.
BC024290 - Homo sapiens deoxynucleotidyltransferase, terminal, interacting protein 1, mRNA (cDNA clone MGC:39276 IMAGE:4099255), complete cds.
CU692912 - Synthetic construct Homo sapiens gateway clone IMAGE:100021949 5' read DNTTIP1 mRNA.
HQ447713 - Synthetic construct Homo sapiens clone IMAGE:100071043; CCSB012698_01 deoxynucleotidyltransferase, terminal, interacting protein 1 (DNTTIP1) gene, encodes complete protein.
BC009535 - Homo sapiens deoxynucleotidyltransferase, terminal, interacting protein 1, mRNA (cDNA clone IMAGE:3892189), partial cds.
JD428184 - Sequence 409208 from Patent EP1572962.
JD253677 - Sequence 234701 from Patent EP1572962.
JD275830 - Sequence 256854 from Patent EP1572962.
JD336207 - Sequence 317231 from Patent EP1572962.
JD131548 - Sequence 112572 from Patent EP1572962.
JD116121 - Sequence 97145 from Patent EP1572962.
JD352421 - Sequence 333445 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RA18, C20orf167, ENST00000372622.1, ENST00000372622.2, ENST00000372622.3, ENST00000372622.4, ENST00000372622.5, ENST00000372622.6, ENST00000372622.7, NM_052951, Q96DE3, Q9BQP2, Q9H147, Q9H148, TDIF1, TDIF1_HUMAN, uc318kbn.1, uc318kbn.2
UCSC ID: ENST00000372622.8_4
RefSeq Accession: NM_052951.3
Protein: Q9H147 (aka TDIF1_HUMAN or TDF1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.