ID:DOCK2_HUMAN DESCRIPTION: RecName: Full=Dedicator of cytokinesis protein 2; FUNCTION: Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. SUBUNIT: Homodimer (Probable). Interacts with RAC1 and RAC2. Interacts with CRKL and VAV. Interacts with CD3Z. SUBCELLULAR LOCATION: Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Colocalizes with F-actin. TISSUE SPECIFICITY: Specifically expressed in hematopoietic cells. Highly expressed in peripheral blood leukocytes, and expressed at intermediate level in thymus and spleen. Expressed at very low level in the small intestine and colon. DOMAIN: The DHR-2 domain may mediate the GEF activity (By similarity). SIMILARITY: Belongs to the DOCK family. SIMILARITY: Contains 1 DHR-1 domain. SIMILARITY: Contains 1 DHR-2 domain. SIMILARITY: Contains 1 SH3 domain. SEQUENCE CAUTION: Sequence=BAA13200.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q92608
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
D86964 - Homo sapiens mRNA for KIAA0209 gene. BC104900 - Homo sapiens dedicator of cytokinesis 2, mRNA (cDNA clone MGC:132560 IMAGE:8143903), complete cds. BC113457 - Homo sapiens dedicator of cytokinesis 2, mRNA (cDNA clone MGC:142017 IMAGE:8322509), complete cds. BC143358 - Homo sapiens cDNA clone IMAGE:9051863. AB463008 - Synthetic construct DNA, clone: pF1KA0209, Homo sapiens DOCK2 gene for dedicator of cytokinesis 2, without stop codon, in Flexi system. BC016996 - Homo sapiens dedicator of cytokinesis 2, mRNA (cDNA clone IMAGE:4413481), complete cds. AK128107 - Homo sapiens cDNA FLJ46228 fis, clone TESTI4014908, highly similar to Dedicator of cytokinesis protein 2. BC035613 - Homo sapiens dedicator of cytokinesis 2, mRNA (cDNA clone IMAGE:4385164), partial cds. BC084556 - Homo sapiens dedicator of cytokinesis 2, mRNA (cDNA clone IMAGE:5933446), partial cds. JD216123 - Sequence 197147 from Patent EP1572962. AK128449 - Homo sapiens cDNA FLJ46592 fis, clone THYMU3045510, highly similar to Dedicator of cytokinesis protein 2. AK130744 - Homo sapiens cDNA FLJ27234 fis, clone SYN07051. JD323286 - Sequence 304310 from Patent EP1572962. JD427461 - Sequence 408485 from Patent EP1572962. JD479699 - Sequence 460723 from Patent EP1572962. JD456118 - Sequence 437142 from Patent EP1572962. JD376416 - Sequence 357440 from Patent EP1572962. JD503341 - Sequence 484365 from Patent EP1572962. JD242413 - Sequence 223437 from Patent EP1572962. JD284821 - Sequence 265845 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q92608 (Reactome details) participates in the following event(s):
R-HSA-200952 Nef binds a ternary complex comprising DOCK2 guanine nucleotide exchange factor for small Rho-family GTPase Rac, its cofactor ELMO1, and Rac, and activates Rac through this interaction R-HSA-1011598 DOCKs bind to RhoGEFs R-HSA-6798749 Exocytosis of specific granule lumen proteins R-HSA-164944 Nef and signal transduction R-HSA-983231 Factors involved in megakaryocyte development and platelet production R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-6798695 Neutrophil degranulation R-HSA-109582 Hemostasis R-HSA-162909 Host Interactions of HIV factors R-HSA-168249 Innate Immune System R-HSA-162906 HIV Infection R-HSA-168256 Immune System R-HSA-5663205 Infectious disease R-HSA-1643685 Disease
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
