Human Gene DOK6 (ENST00000382713.10_4) from GENCODE V47lift37
  Description: docking protein 6 (from RefSeq NM_152721.6)
Gencode Transcript: ENST00000382713.10_4
Gencode Gene: ENSG00000206052.11_8
Transcript (Including UTRs)
   Position: hg19 chr18:67,068,124-67,516,323 Size: 448,200 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr18:67,068,481-67,508,619 Size: 440,139 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr18:67,068,124-67,516,323)mRNA (may differ from genome)Protein (331 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: DOK6_HUMAN
DESCRIPTION: RecName: Full=Docking protein 6; AltName: Full=Downstream of tyrosine kinase 6;
FUNCTION: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret- mediated neurite growth. May have a role in brain development and/or maintenance.
SUBUNIT: Interacts via its PTB domain with phosphorylated RET.
TISSUE SPECIFICITY: Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis.
DOMAIN: PTB domain mediates receptor interaction (By similarity).
PTM: On Ret activation, phosphorylated on one or more C-terminal tyrosine residues by an Src family kinase.
SIMILARITY: Belongs to the DOK family. Type B subfamily.
SIMILARITY: Contains 1 IRS-type PTB domain.
SIMILARITY: Contains 1 PH domain.
SEQUENCE CAUTION: Sequence=BAB71577.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.32 RPKM in Brain - Anterior cingulate cortex (BA24)
Total median expression: 31.30 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -224.50357-0.629 Picture PostScript Text
3' UTR -1917.207704-0.249 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002404 - Insln_rcpt_S1
IPR011993 - PH_like_dom
IPR001849 - Pleckstrin_homology

Pfam Domains:
PF02174 - PTB domain (IRS-1 type)

SCOP Domains:
50729 - PH domain-like

ModBase Predicted Comparative 3D Structure on Q6PKX4
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0007411 axon guidance

Cellular Component:
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  AY599248 - Homo sapiens downstream of tyrosine kinase 6 (DOK6) mRNA, complete cds.
BC096744 - Homo sapiens docking protein 6, mRNA (cDNA clone MGC:104528 IMAGE:5260167), complete cds.
AB528935 - Synthetic construct DNA, clone: pF1KE0759, Homo sapiens DOK6 gene for docking protein 6, without stop codon, in Flexi system.
AK057795 - Homo sapiens cDNA FLJ25066 fis, clone CBL05086.
BC019045 - Homo sapiens docking protein 6, mRNA (cDNA clone IMAGE:4635165), partial cds.
BC008583 - Homo sapiens docking protein 6, mRNA (cDNA clone IMAGE:4214491), partial cds.
KJ904020 - Synthetic construct Homo sapiens clone ccsbBroadEn_13414 DOK6 gene, encodes complete protein.
LF211123 - JP 2014500723-A/18626: Polycomb-Associated Non-Coding RNAs.
LF212753 - JP 2014500723-A/20256: Polycomb-Associated Non-Coding RNAs.
LF213431 - JP 2014500723-A/20934: Polycomb-Associated Non-Coding RNAs.
MA446700 - JP 2018138019-A/18626: Polycomb-Associated Non-Coding RNAs.
MA448330 - JP 2018138019-A/20256: Polycomb-Associated Non-Coding RNAs.
MA449008 - JP 2018138019-A/20934: Polycomb-Associated Non-Coding RNAs.
JD433743 - Sequence 414767 from Patent EP1572962.
JD428197 - Sequence 409221 from Patent EP1572962.
JD494270 - Sequence 475294 from Patent EP1572962.
JD427547 - Sequence 408571 from Patent EP1572962.
JD036482 - Sequence 17506 from Patent EP1572962.
JD091741 - Sequence 72765 from Patent EP1572962.
JD219770 - Sequence 200794 from Patent EP1572962.
JD270299 - Sequence 251323 from Patent EP1572962.
JD453876 - Sequence 434900 from Patent EP1572962.
JD349857 - Sequence 330881 from Patent EP1572962.
JD206660 - Sequence 187684 from Patent EP1572962.
AL512695 - Homo sapiens mRNA; cDNA DKFZp547G133 (from clone DKFZp547G133).

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q6PKX4 (Reactome details) participates in the following event(s):

R-HSA-8855617 2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6
R-HSA-8853659 RET signaling
R-HSA-422475 Axon guidance
R-HSA-1266738 Developmental Biology

-  Other Names for This Gene
  Alternate Gene Symbols: A6NNG3, DOK5L, DOK6_HUMAN, ENST00000382713.1, ENST00000382713.2, ENST00000382713.3, ENST00000382713.4, ENST00000382713.5, ENST00000382713.6, ENST00000382713.7, ENST00000382713.8, ENST00000382713.9, NM_152721, Q4V9S3, Q6PKX4, Q8WUZ8, Q96HI2, Q96LU2, uc318qyv.1, uc318qyv.2
UCSC ID: ENST00000382713.10_4
RefSeq Accession: NM_152721.6
Protein: Q6PKX4 (aka DOK6_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.