Human Gene DRD1 (ENST00000393752.3_7) from GENCODE V47lift37

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Description: dopamine receptor D1 (from RefSeq NM_000794.5)
Gencode Transcript: ENST00000393752.3_7
Gencode Gene: ENSG00000184845.4_9
Transcript (Including UTRs)
Position: hg19 chr5:174,867,039-174,871,185 Size: 4,147 Total Exon Count: 2 Strand: -
Coding Region
Position: hg19 chr5:174,868,762-174,870,102 Size: 1,341 Coding Exon Count: 1

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr5:174,867,039-174,871,185)			mRNA (may differ from genome)		Protein (446 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Human Cortex Gene Expression	Malacards	MGI	OMIM	PubMed
Reactome	UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: DRD1_HUMAN DESCRIPTION: RecName: Full=D(1A) dopamine receptor; AltName: Full=Dopamine D1 receptor; FUNCTION: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. SUBUNIT: Interacts with DNAJC14 via its C-terminus (By similarity). Interacts with DRD1IP. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Note=Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14 (By similarity). TISSUE SPECIFICITY: Detected in caudate, nucleus accumbens and in the olfactory tubercle. SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

Primer design for this transcript

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Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: DRD1 Diseases sorted by gene-association score: cerebral meningioma (25), drug addiction (19), pathological gambling (10), early-onset schizophrenia (7), bipolar i disorder (6), attention deficit-hyperactivity disorder (6), transient cerebral ischemia (6), bardet-biedl syndrome 17 (5), alcohol dependence (3), schizophrenia (3), obsessive-compulsive disorder (3), psychotic disorder (3), parkinson disease, late-onset (2), autism spectrum disorder (1), narcolepsy (1)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C534628 SCH 23390 D015647 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine D003042 Cocaine C095427 A 86929 D000242 Cyclic AMP D018818 Fenoldopam D005475 Flupenthixol D006220 Haloperidol D007980 Levodopa C071262 SK&F 82958 C079415 A 77636 D001058 Apomorphine D003024 Clozapine D004298 Dopamine D010042 Ouabain D010479 Pergolide C067113 SK&F 81297 C067114 SK&F 77434 C058081 ecopipam D015632 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine C107238 1-propyl-5-(3-p-tolylisoxazol-5-yl)-1,2,3,6-tetrahydropyridine C077358 7-benzylidenenaltrexone C061450 A 69024 C065380 A 68930 D001545 Benserazide D001623 Betamethasone C054531 CY 208-243 D002220 Carbamazepine D016291 Dizocilpine Maleate C071320 FCE 23884 D005444 Flunarizine D004397 Fonofos D005557 Formaldehyde D007546 Isoquinolines C409874 LE 300 D008094 Lithium D008694 Methamphetamine D008731 Methoxychlor D008787 Metoclopramide C047508 N 0437 C076525 NO 756 C106996 NRA 0045 D016627 Oxidopamine D010278 Parathion D010431 Pentoxifylline D010546 Perphenazine D010627 Phenethylamines D010830 Physostigmine D010862 Pilocarpine D015363 Quinolones D012110 Reserpine C080703 SK&F 83959 C099238 SKF 82957 D019821 Simvastatin D013134 Spiperone C094142 TAN 67 D013749 Tetrachlorodibenzodioxin C095428 adrogolide hydrochloride C016601 afimoxifene C011686 boldine C047047 cabergoline C061532 dihydrexidine C097827 dinapsoline C001162 etafenone C035420 levodopa methyl ester C054218 manidipine C075357 odapipam C015586 propiverine C012568 terbufos C014215 tetrahydropalmatine

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 20.01 RPKM in Brain - Nucleus accumbens (basal ganglia) Total median expression: 69.50 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-393.20	967	-0.407	Picture	PostScript	Text
3' UTR	-399.20	1723	-0.232	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR001413 - Dopa_1A_rcpt
IPR000929 - Dopamine_rcpt
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF10320 - Serpentine type 7TM GPCR chemoreceptor Srsx
PF10328 - Serpentine type 7TM GPCR chemoreceptor Srx

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1OZ5 - Model

ModBase Predicted Comparative 3D Structure on P21728


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	No ortholog
Gene Details	Gene Details		Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase
				Protein Sequence
				Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs GO:0004871 signal transducer activity GO:0004930 G-protein coupled receptor activity GO:0004952 dopamine neurotransmitter receptor activity GO:0005515 protein binding GO:0035240 dopamine binding Biological Process: GO:0001659 temperature homeostasis GO:0001661 conditioned taste aversion GO:0001662 behavioral fear response GO:0001932 regulation of protein phosphorylation GO:0001963 synaptic transmission, dopaminergic GO:0001975 response to amphetamine GO:0006606 protein import into nucleus GO:0006936 muscle contraction GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007190 activation of adenylate cyclase activity GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway GO:0007212 dopamine receptor signaling pathway GO:0007416 synapse assembly GO:0007612 learning GO:0007613 memory GO:0007617 mating behavior GO:0007625 grooming behavior GO:0007626 locomotory behavior GO:0007628 adult walking behavior GO:0007631 feeding behavior GO:0008306 associative learning GO:0008542 visual learning GO:0010628 positive regulation of gene expression GO:0014002 astrocyte development GO:0015872 dopamine transport GO:0019226 transmission of nerve impulse GO:0019228 neuronal action potential GO:0021542 dentate gyrus development GO:0021756 striatum development GO:0021766 hippocampus development GO:0021853 cerebral cortex GABAergic interneuron migration GO:0030335 positive regulation of cell migration GO:0030432 peristalsis GO:0035106 operant conditioning GO:0042053 regulation of dopamine metabolic process GO:0042220 response to cocaine GO:0042311 vasodilation GO:0042417 dopamine metabolic process GO:0042493 response to drug GO:0042711 maternal behavior GO:0043268 positive regulation of potassium ion transport GO:0043987 histone H3-S10 phosphorylation GO:0046323 glucose import GO:0046959 habituation GO:0046960 sensitization GO:0048148 behavioral response to cocaine GO:0051281 positive regulation of release of sequestered calcium ion into cytosol GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway GO:0051584 regulation of dopamine uptake involved in synaptic transmission GO:0051968 positive regulation of synaptic transmission, glutamatergic GO:0060134 prepulse inhibition GO:0060158 phospholipase C-activating dopamine receptor signaling pathway GO:0060291 long-term synaptic potentiation GO:0060292 long term synaptic depression GO:0071870 cellular response to catecholamine stimulus GO:1903351 cellular response to dopamine Cellular Component: GO:0005634 nucleus GO:0005783 endoplasmic reticulum GO:0005789 endoplasmic reticulum membrane GO:0005886 plasma membrane GO:0005887 integral component of plasma membrane GO:0012505 endomembrane system GO:0016020 membrane GO:0016021 integral component of membrane GO:0060170 ciliary membrane GO:0097730 non-motile cilium

Descriptions from all associated GenBank mRNAs


	X58987 - Human mRNA for D-1 dopamine receptor. JD063515 - Sequence 44539 from Patent EP1572962. JD442305 - Sequence 423329 from Patent EP1572962. JD339607 - Sequence 320631 from Patent EP1572962. JD492627 - Sequence 473651 from Patent EP1572962. JD174313 - Sequence 155337 from Patent EP1572962. JD156773 - Sequence 137797 from Patent EP1572962. BC074978 - Homo sapiens dopamine receptor D1, mRNA (cDNA clone MGC:104066 IMAGE:30915514), complete cds. BC074979 - Homo sapiens dopamine receptor D1, mRNA (cDNA clone MGC:103908 IMAGE:30915297), complete cds. JD096706 - Sequence 77730 from Patent EP1572962. AF498961 - Homo sapiens dopamine receptor D1 (DRD1) mRNA, complete cds. BC096837 - Homo sapiens dopamine receptor D1, mRNA (cDNA clone MGC:111723 IMAGE:6519220), complete cds. AK314031 - Homo sapiens cDNA, FLJ94691, Homo sapiens dopamine receptor D1 (DRD1), mRNA. KJ896726 - Synthetic construct Homo sapiens clone ccsbBroadEn_06120 DRD1 gene, encodes complete protein. KR712130 - Synthetic construct Homo sapiens clone CCSBHm_00036023 DRD1 (DRD1) mRNA, encodes complete protein. KR712131 - Synthetic construct Homo sapiens clone CCSBHm_00036024 DRD1 (DRD1) mRNA, encodes complete protein. KR712132 - Synthetic construct Homo sapiens clone CCSBHm_00036026 DRD1 (DRD1) mRNA, encodes complete protein. KR712133 - Synthetic construct Homo sapiens clone CCSBHm_00036027 DRD1 (DRD1) mRNA, encodes complete protein. AB529221 - Synthetic construct DNA, clone: pF1KB9867, Homo sapiens DRD1 gene for dopamine receptor D1, without stop codon, in Flexi system. CR541922 - Homo sapiens full open reading frame cDNA clone RZPDo834F0933D for gene DRD1, dopamine receptor D1; complete cds, without stopcodon. JD438413 - Sequence 419437 from Patent EP1572962. JD298654 - Sequence 279678 from Patent EP1572962. JD410059 - Sequence 391083 from Patent EP1572962. JD483929 - Sequence 464953 from Patent EP1572962. JD287939 - Sequence 268963 from Patent EP1572962. JD196688 - Sequence 177712 from Patent EP1572962. JD205834 - Sequence 186858 from Patent EP1572962. JD424022 - Sequence 405046 from Patent EP1572962. JD169511 - Sequence 150535 from Patent EP1572962. JD056976 - Sequence 38000 from Patent EP1572962. JD322837 - Sequence 303861 from Patent EP1572962. JD173100 - Sequence 154124 from Patent EP1572962. JD312356 - Sequence 293380 from Patent EP1572962. JD437149 - Sequence 418173 from Patent EP1572962. JD152899 - Sequence 133923 from Patent EP1572962. JD271984 - Sequence 253008 from Patent EP1572962. JD140030 - Sequence 121054 from Patent EP1572962. JD194005 - Sequence 175029 from Patent EP1572962.

Biochemical and Signaling Pathways


	BioCarta from NCI Cancer Genome Anatomy Project h_ck1Pathway - Regulation of ck1/cdk5 by type 1 glutamate receptors Reactome (by CSHL, EBI, and GO) Protein P21728 (Reactome details) participates in the following event(s): R-HSA-390835 D1-like dopamine receptors bind to dopamine R-HSA-744886 The Ligand:GPCR:Gs complex dissociates R-HSA-744887 Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs R-HSA-379044 Liganded Gs-activating GPCR acts as a GEF for Gs R-HSA-390651 Dopamine receptors R-HSA-418555 G alpha (s) signalling events R-HSA-375280 Amine ligand-binding receptors R-HSA-388396 GPCR downstream signalling R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-372790 Signaling by GPCR R-HSA-500792 GPCR ligand binding R-HSA-162582 Signal Transduction

Other Names for This Gene


	Alternate Gene Symbols: B2RA44, DRD1_HUMAN, ENST00000393752.1, ENST00000393752.2, NM_000794, P21728, Q4QRJ0, uc318wco.1, uc318wco.2 UCSC ID: ENST00000393752.3_7 RefSeq Accession: NM_000794.5 Protein: P21728 (aka DRD1_HUMAN or DADR_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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