ID:DRG1_HUMAN DESCRIPTION: RecName: Full=Developmentally-regulated GTP-binding protein 1; Short=DRG-1; AltName: Full=Neural precursor cell expressed developmentally down-regulated protein 3; Short=NEDD-3; FUNCTION: Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest. SUBUNIT: Interacts (via its C-terminal) with TAL1. Interacts with ZC3H15; the interaction forms a polysomal DRG1-DFRP1/ZC3H15 complex which provides protein stability to DRG1 possibly by blocking poly-ubiquitination. Interacts with STK16; the interaction phosphorylates STK16 (By similarity). INTERACTION: Q9H446:RWDD1; NbExp=2; IntAct=EBI-719554, EBI-748952; SUBCELLULAR LOCATION: Cytoplasm. Note=The DRG1-DFRP2/ZC3H15 complex associates with polysomes. TISSUE SPECIFICITY: High levels in skeletal muscle, heart, and kidney. Intermediate levels in liver, placenta and brain. Low levels in colon, thymus, spleen, small intestine, lung and leukocytes. INDUCTION: By androgens. PTM: Sumoylated by UBE2I in response to MEKK1-mediated stimuli. SIMILARITY: Belongs to the GTP1/OBG family. SIMILARITY: Contains 1 G (guanine nucleotide-binding) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF01926 - 50S ribosome-binding GTPase PF02421 - Ferrous iron transport protein B PF02824 - TGS domain PF16897 - C-terminal region of MMR_HSR1 domain
ModBase Predicted Comparative 3D Structure on Q9Y295
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.