Human Gene DRG1 (ENST00000331457.9_4) from GENCODE V47lift37
  Description: developmentally regulated GTP binding protein 1 (from RefSeq NM_004147.4)
Gencode Transcript: ENST00000331457.9_4
Gencode Gene: ENSG00000185721.14_14
Transcript (Including UTRs)
   Position: hg19 chr22:31,795,590-31,830,438 Size: 34,849 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg19 chr22:31,795,670-31,829,957 Size: 34,288 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:31,795,590-31,830,438)mRNA (may differ from genome)Protein (367 aa)
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BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: DRG1_HUMAN
DESCRIPTION: RecName: Full=Developmentally-regulated GTP-binding protein 1; Short=DRG-1; AltName: Full=Neural precursor cell expressed developmentally down-regulated protein 3; Short=NEDD-3;
FUNCTION: Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest.
SUBUNIT: Interacts (via its C-terminal) with TAL1. Interacts with ZC3H15; the interaction forms a polysomal DRG1-DFRP1/ZC3H15 complex which provides protein stability to DRG1 possibly by blocking poly-ubiquitination. Interacts with STK16; the interaction phosphorylates STK16 (By similarity).
INTERACTION: Q9H446:RWDD1; NbExp=2; IntAct=EBI-719554, EBI-748952;
SUBCELLULAR LOCATION: Cytoplasm. Note=The DRG1-DFRP2/ZC3H15 complex associates with polysomes.
TISSUE SPECIFICITY: High levels in skeletal muscle, heart, and kidney. Intermediate levels in liver, placenta and brain. Low levels in colon, thymus, spleen, small intestine, lung and leukocytes.
INDUCTION: By androgens.
PTM: Sumoylated by UBE2I in response to MEKK1-mediated stimuli.
SIMILARITY: Belongs to the GTP1/OBG family.
SIMILARITY: Contains 1 G (guanine nucleotide-binding) domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 144.76 RPKM in Testis
Total median expression: 1145.84 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -30.8080-0.385 Picture PostScript Text
3' UTR -129.20481-0.269 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006074 - GTP1-OBG_CS
IPR006073 - GTP_binding_domain
IPR005225 - Small_GTP-bd_dom
IPR004095 - TGS
IPR012676 - TGS-like

Pfam Domains:
PF01926 - 50S ribosome-binding GTPase
PF02421 - Ferrous iron transport protein B
PF02824 - TGS domain
PF16897 - C-terminal region of MMR_HSR1 domain

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases
53795 - PEP carboxykinase-like
81271 - TGS-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2EKI - NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q9Y295
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 RGDEnsembl WormBaseSGD
     Protein Sequence
     Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0008134 transcription factor binding
GO:0042802 identical protein binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0007275 multicellular organism development

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005844 polysome
GO:0016020 membrane
GO:0016604 nuclear body


-  Descriptions from all associated GenBank mRNAs
  AK315659 - Homo sapiens cDNA, FLJ96750, Homo sapiens developmentally regulated GTP binding protein 1(DRG1), mRNA.
BC019285 - Homo sapiens developmentally regulated GTP binding protein 1, mRNA (cDNA clone MGC:4011 IMAGE:2823263), complete cds.
AJ005940 - Homo sapiens mRNA for GTP-binding protein.
BC020803 - Homo sapiens developmentally regulated GTP binding protein 1, mRNA (cDNA clone MGC:23799 IMAGE:4250998), complete cds.
AF078103 - Homo sapiens developmentally regulated GTP-binding protein (DRG) mRNA, complete cds.
JD081915 - Sequence 62939 from Patent EP1572962.
AK098576 - Homo sapiens cDNA FLJ25710 fis, clone TST04974, highly similar to DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN DRG1.
JD293624 - Sequence 274648 from Patent EP1572962.
JD565095 - Sequence 546119 from Patent EP1572962.
CR456488 - Homo sapiens DRG1 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.DRG1.V2).
JD215577 - Sequence 196601 from Patent EP1572962.
DQ890690 - Synthetic construct clone IMAGE:100003320; FLH165157.01X; RZPDo839G08158D developmentally regulated GTP binding protein 1 (DRG1) gene, encodes complete protein.
DQ893872 - Synthetic construct Homo sapiens clone IMAGE:100008332; FLH165153.01L; RZPDo839G08157D developmentally regulated GTP binding protein 1 (DRG1) gene, encodes complete protein.
CU013336 - Homo sapiens DRG1, mRNA (cDNA clone IMAGE:100000210), complete cds, without stop codon, in Gateway system.
CU013048 - Homo sapiens DRG1, mRNA (cDNA clone IMAGE:100000306), complete cds, with stop codon, in Gateway system.
CU676724 - Synthetic construct Homo sapiens gateway clone IMAGE:100021913 5' read DRG1 mRNA.
KJ891686 - Synthetic construct Homo sapiens clone ccsbBroadEn_01080 DRG1 gene, encodes complete protein.
KJ897233 - Synthetic construct Homo sapiens clone ccsbBroadEn_06627 DRG1 gene, encodes complete protein.
AB463011 - Synthetic construct DNA, clone: pF1KB3406, Homo sapiens DRG1 gene for developmentally regulated GTP binding protein 1, without stop codon, in Flexi system.
CR542059 - Homo sapiens full open reading frame cDNA clone RZPDo834C1036D for gene DRG1, developmentally regulated GTP binding protein 1; complete cds, without stopcodon.
BT007237 - Homo sapiens developmentally regulated GTP binding protein 1 mRNA, complete cds.
DQ594217 - Homo sapiens piRNA piR-60329, complete sequence.
AL133085 - Homo sapiens mRNA; cDNA DKFZp434N1827 (from clone DKFZp434N1827).
JD331388 - Sequence 312412 from Patent EP1572962.
JD049304 - Sequence 30328 from Patent EP1572962.
JD085639 - Sequence 66663 from Patent EP1572962.
JD518607 - Sequence 499631 from Patent EP1572962.
JD540829 - Sequence 521853 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RDS8, DRG1 , DRG1_HUMAN, ENST00000331457.1, ENST00000331457.2, ENST00000331457.3, ENST00000331457.4, ENST00000331457.5, ENST00000331457.6, ENST00000331457.7, ENST00000331457.8, NEDD3, NM_004147, Q6FGP8, Q8WW69, Q9UGF2, Q9Y295, uc317tfl.1, uc317tfl.2
UCSC ID: ENST00000331457.9_4
RefSeq Accession: NM_004147.4
Protein: Q9Y295 (aka DRG1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.