Human Gene DST (ENST00000680361.1_7) from GENCODE V47lift37
  Description: dystonin, transcript variant 4 (from RefSeq NM_001374736.1)
Gencode Transcript: ENST00000680361.1_7
Gencode Gene: ENSG00000151914.22_23
Transcript (Including UTRs)
   Position: hg19 chr6:56,322,794-56,819,628 Size: 496,835 Total Exon Count: 104 Strand: -
Coding Region
   Position: hg19 chr6:56,323,803-56,819,385 Size: 495,583 Coding Exon Count: 104 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
Microarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther NamesGeneReviews
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:56,322,794-56,819,628)mRNA (may differ from genome)Protein (7818 aa)
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-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: DST
Diseases sorted by gene-association score: neuropathy, hereditary sensory and autonomic, type vi* (1400), epidermolysis bullosa simplex, autosomal recessive 2* (1369), bullous pemphigoid (37), bullous skin disease (26), herpes gestationis (24), lichen planus (22), epidermolysis bullosa simplex (22), cicatricial pemphigoid (21), lichen planus pemphigoides (19), pemphigus foliaceus (16), epidermolysis bullosa (15), epidermolysis bullosa acquisita (14), autoimmune disease of skin and connective tissue (14), pemphigus vulgaris (14), junctional epidermolysis bullosa (13), pemphigoid gestationis (13), epidermolysis bullosa, junctional, non-herlitz type (11), pemphigus (11), herpetiform pemphigus (10), linear iga disease (10), autonomic neuropathy (10), skin disease (10), kindler syndrome (9), neurotic excoriation (9), epidermolysis bullosa simplex with muscular dystrophy (9), epidermolysis bullosa, junctional, with pyloric stenosis (8), paraneoplastic pemphigus (8), impetigo herpetiformis (7), ecthyma (6), vesiculobullous skin disease (6), lichen disease (6), epidermolysis bullosa dystrophica (6), subcorneal pustular dermatosis (4), hypersensitivity reaction disease (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -126.10243-0.519 Picture PostScript Text
3' UTR -227.601009-0.226 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Descriptions from all associated GenBank mRNAs
  AK299898 - Homo sapiens cDNA FLJ59296 partial cds, highly similar to Bullous pemphigoid antigen 1 isoforms1/2/3/4/5/8.
AK294830 - Homo sapiens cDNA FLJ55162 complete cds, highly similar to Bullous pemphigoid antigen 1 isoforms 1/2/3/4/5/8.
U31850 - Human dystonin isoform 1 mRNA, partial cds.
U31851 - Human dystonin isoform 2 mRNA, partial cds.
AB018271 - Homo sapiens mRNA for KIAA0728 protein, partial cds.
AF400226 - Homo sapiens bullous pemphigoid antigen 1 eA (BPAG1) mRNA, complete cds.
AK096713 - Homo sapiens cDNA FLJ39394 fis, clone PLACE6007925, moderately similar to Homo sapiens mRNA for actin binding protein ABP620.
AK128632 - Homo sapiens cDNA FLJ46791 fis, clone TRACH3029462, moderately similar to Actin cross-linking family protein 7.
AF400227 - Homo sapiens bullous pemphigoid antigen 1 eB (BPAG1) mRNA, partial cds.
M69225 - Human bullous pemphigoid antigen (BPAG1) mRNA, complete cds.
M63618 - Human bullous pemphigoid antigen mRNA, complete cds.
L11690 - Human bullous 230 kDa pemphigoid antigen (BPAG1) mRNA, complete cds.
LF205176 - JP 2014500723-A/12679: Polycomb-Associated Non-Coding RNAs.
BC065536 - Homo sapiens dystonin, mRNA (cDNA clone IMAGE:6008053), complete cds.
HQ257995 - Synthetic construct Homo sapiens clone IMAGE:100072304 Unknown protein gene, encodes complete protein.
KJ901304 - Synthetic construct Homo sapiens clone ccsbBroadEn_10698 DST gene, encodes complete protein.
MA440753 - JP 2018138019-A/12679: Polycomb-Associated Non-Coding RNAs.
AL110142 - Homo sapiens mRNA; cDNA DKFZp564D0264 (from clone DKFZp564D0264).
BC023254 - Homo sapiens dystonin, mRNA (cDNA clone IMAGE:4471294), with apparent retained intron.
BC051772 - Homo sapiens dystonin, mRNA (cDNA clone IMAGE:6193128), partial cds.
BC004912 - Homo sapiens dystonin, mRNA (cDNA clone IMAGE:3534745), partial cds.
AK095166 - Homo sapiens cDNA FLJ37847 fis, clone BRSSN2013095.
AK056797 - Homo sapiens cDNA FLJ32235 fis, clone PLACE6004738.
AK023487 - Homo sapiens cDNA FLJ13425 fis, clone PLACE1002342, highly similar to Homo sapiens mRNA for KIAA0728 protein.
JD298444 - Sequence 279468 from Patent EP1572962.
JD345292 - Sequence 326316 from Patent EP1572962.
JD362484 - Sequence 343508 from Patent EP1572962.
JD263833 - Sequence 244857 from Patent EP1572962.
JD536015 - Sequence 517039 from Patent EP1572962.
JD259448 - Sequence 240472 from Patent EP1572962.
JD056571 - Sequence 37595 from Patent EP1572962.
JD490890 - Sequence 471914 from Patent EP1572962.
AK025142 - Homo sapiens cDNA: FLJ21489 fis, clone COL05450.
LF205177 - JP 2014500723-A/12680: Polycomb-Associated Non-Coding RNAs.
LF317286 - JP 2014500723-A/124789: Polycomb-Associated Non-Coding RNAs.
LF317285 - JP 2014500723-A/124788: Polycomb-Associated Non-Coding RNAs.
AF083131 - Homo sapiens CATX-15 mRNA, complete cds.
AK055189 - Homo sapiens cDNA FLJ30627 fis, clone CTONG2001955, moderately similar to Homo sapiens mRNA for actin binding protein ABP620.
AK090517 - Homo sapiens cDNA FLJ33198 fis, clone ADRGL2006233, moderately similar to Homo sapiens trabeculin-alpha mRNA.
AX746491 - Sequence 16 from Patent EP1308459.
X75692 - H.sapiens (TL21) mRNA from LNCaP cell line.
AK094883 - Homo sapiens cDNA FLJ37564 fis, clone BRCOC2000816, weakly similar to Homo sapiens mRNA for actin binding protein ABP620.
BC016991 - Homo sapiens dystonin, mRNA (cDNA clone IMAGE:4400287), partial cds.
AK125655 - Homo sapiens cDNA FLJ43667 fis, clone SYNOV4007215.
LF317278 - JP 2014500723-A/124781: Polycomb-Associated Non-Coding RNAs.
LF317277 - JP 2014500723-A/124780: Polycomb-Associated Non-Coding RNAs.
MA440754 - JP 2018138019-A/12680: Polycomb-Associated Non-Coding RNAs.
MA552863 - JP 2018138019-A/124789: Polycomb-Associated Non-Coding RNAs.
MA552862 - JP 2018138019-A/124788: Polycomb-Associated Non-Coding RNAs.
MA552855 - JP 2018138019-A/124781: Polycomb-Associated Non-Coding RNAs.
MA552854 - JP 2018138019-A/124780: Polycomb-Associated Non-Coding RNAs.
LF317276 - JP 2014500723-A/124779: Polycomb-Associated Non-Coding RNAs.
LF317275 - JP 2014500723-A/124778: Polycomb-Associated Non-Coding RNAs.
LF317274 - JP 2014500723-A/124777: Polycomb-Associated Non-Coding RNAs.
LF317273 - JP 2014500723-A/124776: Polycomb-Associated Non-Coding RNAs.
LF317272 - JP 2014500723-A/124775: Polycomb-Associated Non-Coding RNAs.
LF317271 - JP 2014500723-A/124774: Polycomb-Associated Non-Coding RNAs.
LF317270 - JP 2014500723-A/124773: Polycomb-Associated Non-Coding RNAs.
LF317269 - JP 2014500723-A/124772: Polycomb-Associated Non-Coding RNAs.
LF317268 - JP 2014500723-A/124771: Polycomb-Associated Non-Coding RNAs.
LF317267 - JP 2014500723-A/124770: Polycomb-Associated Non-Coding RNAs.
AK295864 - Homo sapiens cDNA FLJ54409 complete cds, highly similar to Bullous pemphigoid antigen 1 isoforms 1/2/3/4/5/8.
AY032900 - Homo sapiens IMAGE:413590 dystonin 2 mRNA, partial cds.
AY032901 - Homo sapiens IMAGE:413638 dystonin 2 mRNA, partial cds.
JD026125 - Sequence 7149 from Patent EP1572962.
JD032307 - Sequence 13331 from Patent EP1572962.
AF165191 - Homo sapiens BPAG1n3 (BPAG1) mRNA, partial cds.
MA552853 - JP 2018138019-A/124779: Polycomb-Associated Non-Coding RNAs.
MA552852 - JP 2018138019-A/124778: Polycomb-Associated Non-Coding RNAs.
MA552851 - JP 2018138019-A/124777: Polycomb-Associated Non-Coding RNAs.
MA552850 - JP 2018138019-A/124776: Polycomb-Associated Non-Coding RNAs.
MA552849 - JP 2018138019-A/124775: Polycomb-Associated Non-Coding RNAs.
MA552848 - JP 2018138019-A/124774: Polycomb-Associated Non-Coding RNAs.
MA552847 - JP 2018138019-A/124773: Polycomb-Associated Non-Coding RNAs.
MA552846 - JP 2018138019-A/124772: Polycomb-Associated Non-Coding RNAs.
MA552845 - JP 2018138019-A/124771: Polycomb-Associated Non-Coding RNAs.
MA552844 - JP 2018138019-A/124770: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A0A7P0T890, A0A7P0T890_HUMAN, DST , NM_001374736, uc330gwb.1, uc330gwb.2
UCSC ID: ENST00000680361.1_7
RefSeq Accession: NM_001374736.1

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene DST:
ebs (Epidermolysis Bullosa Simplex)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.