Human Gene DSTN (ENST00000246069.12_4) from GENCODE V47lift37
  Description: destrin, actin depolymerizing factor, transcript variant 1 (from RefSeq NM_006870.4)
Gencode Transcript: ENST00000246069.12_4
Gencode Gene: ENSG00000125868.16_7
Transcript (Including UTRs)
   Position: hg19 chr20:17,550,720-17,590,564 Size: 39,845 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr20:17,550,854-17,587,791 Size: 36,938 Coding Exon Count: 4 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr20:17,550,720-17,590,564)mRNA (may differ from genome)Protein (165 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: DSTN
Diseases sorted by gene-association score: necatoriasis (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 958.67 RPKM in Artery - Tibial
Total median expression: 7863.75 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -53.90134-0.402 Picture PostScript Text
3' UTR -824.702773-0.297 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGD    
      
      

-  Descriptions from all associated GenBank mRNAs
  EU794606 - Homo sapiens epididymis luminal protein 32 (HEL32) mRNA, complete cds.
AK315994 - Homo sapiens cDNA, FLJ78893 complete cds, highly similar to Destrin.
BC009477 - Homo sapiens destrin (actin depolymerizing factor), mRNA (cDNA clone MGC:15087 IMAGE:3938287), complete cds.
GQ900922 - Homo sapiens clone HEL-T-34 epididymis secretory sperm binding protein mRNA, complete cds.
AK312645 - Homo sapiens cDNA, FLJ93031, Homo sapiens destrin (actin depolymerizing factor) (DSTN), mRNA.
BX647319 - Homo sapiens mRNA; cDNA DKFZp686O20275 (from clone DKFZp686O20275).
S65738 - actin depolymerizing factor [human, fetal brain, mRNA, 1452 nt].
AK302338 - Homo sapiens cDNA FLJ52030 complete cds, highly similar to Destrin.
AK308562 - Homo sapiens cDNA, FLJ98603.
CR457042 - Homo sapiens full open reading frame cDNA clone RZPDo834B0515D for gene DSTN, destrin (actin depolymerizing factor); complete cds, incl. stopcodon.
AB529054 - Synthetic construct DNA, clone: pF1KB3718, Homo sapiens DSTN gene for destrin, without stop codon, in Flexi system.
CR541956 - Homo sapiens full open reading frame cDNA clone RZPDo834H0334D for gene DSTN, destrin (actin depolymerizing factor); complete cds, without stopcodon.
JF432564 - Synthetic construct Homo sapiens clone IMAGE:100073796 destrin (actin depolymerizing factor) (DSTN) gene, encodes complete protein.
KJ893208 - Synthetic construct Homo sapiens clone ccsbBroadEn_02602 DSTN gene, encodes complete protein.
JD265714 - Sequence 246738 from Patent EP1572962.
JD040270 - Sequence 21294 from Patent EP1572962.
JD111275 - Sequence 92299 from Patent EP1572962.
JD083513 - Sequence 64537 from Patent EP1572962.
JD561780 - Sequence 542804 from Patent EP1572962.
JD142450 - Sequence 123474 from Patent EP1572962.
JD132127 - Sequence 113151 from Patent EP1572962.
JD148685 - Sequence 129709 from Patent EP1572962.
JD379775 - Sequence 360799 from Patent EP1572962.
JD312252 - Sequence 293276 from Patent EP1572962.
JD312254 - Sequence 293278 from Patent EP1572962.
JD312255 - Sequence 293279 from Patent EP1572962.
JD346787 - Sequence 327811 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000246069.1, ENST00000246069.10, ENST00000246069.11, ENST00000246069.2, ENST00000246069.3, ENST00000246069.4, ENST00000246069.5, ENST00000246069.6, ENST00000246069.7, ENST00000246069.8, ENST00000246069.9, HEL32 , NM_006870, uc317esj.1, uc317esj.2, V9HWA6, V9HWA6_HUMAN
UCSC ID: ENST00000246069.12_4
RefSeq Accession: NM_006870.4

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.