ID:DTX3L_HUMAN DESCRIPTION: RecName: Full=E3 ubiquitin-protein ligase DTX3L; EC=6.3.2.-; AltName: Full=B-lymphoma- and BAL-associated protein; AltName: Full=Protein deltex-3-like; AltName: Full=Rhysin-2; Short=Rhysin2; FUNCTION: Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post- translational modifications such as H4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Homodimer and heterodimer. Can heterodimerize with DTX1, enhancing its ubiquitin ligase activity in vitro. Interacts with PARP9/BAL1. Found in a complex with MYO6. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. INDUCTION: By IFNG/IFN-gamma. SIMILARITY: Belongs to the Deltex family. SIMILARITY: Contains 1 RING-type zinc finger.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8TDB6
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000209 protein polyubiquitination GO:0002230 positive regulation of defense response to virus by host GO:0002376 immune system process GO:0006281 DNA repair GO:0006302 double-strand break repair GO:0006325 chromatin organization GO:0006511 ubiquitin-dependent protein catabolic process GO:0006974 cellular response to DNA damage stimulus GO:0008333 endosome to lysosome transport GO:0010390 histone monoubiquitination GO:0015031 protein transport GO:0016567 protein ubiquitination GO:0032092 positive regulation of protein binding GO:0033522 histone H2A ubiquitination GO:0033523 histone H2B ubiquitination GO:0035563 positive regulation of chromatin binding GO:0045087 innate immune response GO:0045893 positive regulation of transcription, DNA-templated GO:0051444 negative regulation of ubiquitin-protein transferase activity GO:0051607 defense response to virus GO:0051865 protein autoubiquitination GO:0070936 protein K48-linked ubiquitination GO:1900182 positive regulation of protein localization to nucleus GO:1901666 positive regulation of NAD+ ADP-ribosyltransferase activity GO:1902966 positive regulation of protein localization to early endosome GO:2000646 positive regulation of receptor catabolic process GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining
LF210604 - JP 2014500723-A/18107: Polycomb-Associated Non-Coding RNAs. AY225123 - Homo sapiens B-lymphoma and BAL associated protein (BBAP) mRNA, complete cds. AK125086 - Homo sapiens cDNA FLJ43096 fis, clone CTONG1000467, highly similar to Protein deltex 3-like protein. BC060509 - Homo sapiens deltex 3-like (Drosophila), mRNA (cDNA clone MGC:62133 IMAGE:6457163), complete cds. AL833598 - Homo sapiens mRNA; cDNA DKFZp686C0867 (from clone DKFZp686C0867). BC042191 - Homo sapiens deltex 3-like (Drosophila), mRNA (cDNA clone MGC:47846 IMAGE:4339554), complete cds. KJ895660 - Synthetic construct Homo sapiens clone ccsbBroadEn_05054 DTX3L gene, encodes complete protein. AF484416 - Homo sapiens rhysin 2 mRNA, complete cds. AY780792 - Homo sapiens rhysin 2 mRNA, complete cds, alternatively spliced. BX648645 - Homo sapiens mRNA; cDNA DKFZp686K02113 (from clone DKFZp686K02113). BX648267 - Homo sapiens mRNA; cDNA DKFZp686N20115 (from clone DKFZp686N20115). AK056406 - Homo sapiens cDNA FLJ31844 fis, clone NT2RP7000364. BC040372 - Homo sapiens deltex 3-like (Drosophila), mRNA (cDNA clone IMAGE:4510630). MA446181 - JP 2018138019-A/18107: Polycomb-Associated Non-Coding RNAs. CU692078 - Synthetic construct Homo sapiens gateway clone IMAGE:100021237 5' read DTX3L mRNA. LF339144 - JP 2014500723-A/146647: Polycomb-Associated Non-Coding RNAs. LF339139 - JP 2014500723-A/146642: Polycomb-Associated Non-Coding RNAs. LF339138 - JP 2014500723-A/146641: Polycomb-Associated Non-Coding RNAs. MA574721 - JP 2018138019-A/146647: Polycomb-Associated Non-Coding RNAs. MA574716 - JP 2018138019-A/146642: Polycomb-Associated Non-Coding RNAs. MA574715 - JP 2018138019-A/146641: Polycomb-Associated Non-Coding RNAs. JD338436 - Sequence 319460 from Patent EP1572962. JD558428 - Sequence 539452 from Patent EP1572962. JD272087 - Sequence 253111 from Patent EP1572962. JD198505 - Sequence 179529 from Patent EP1572962. JD153345 - Sequence 134369 from Patent EP1572962. JD161709 - Sequence 142733 from Patent EP1572962. AK093782 - Homo sapiens cDNA FLJ36463 fis, clone THYMU2015019. AX748303 - Sequence 1828 from Patent EP1308459. JD247645 - Sequence 228669 from Patent EP1572962. JD219621 - Sequence 200645 from Patent EP1572962. JD502618 - Sequence 483642 from Patent EP1572962. JD087059 - Sequence 68083 from Patent EP1572962. JD262061 - Sequence 243085 from Patent EP1572962. JD560935 - Sequence 541959 from Patent EP1572962. JD542893 - Sequence 523917 from Patent EP1572962. JD212997 - Sequence 194021 from Patent EP1572962. JD487382 - Sequence 468406 from Patent EP1572962. JD321783 - Sequence 302807 from Patent EP1572962. JD321782 - Sequence 302806 from Patent EP1572962. JD342493 - Sequence 323517 from Patent EP1572962. JD480594 - Sequence 461618 from Patent EP1572962. JD254862 - Sequence 235886 from Patent EP1572962. JD505231 - Sequence 486255 from Patent EP1572962. JD106815 - Sequence 87839 from Patent EP1572962. JD096899 - Sequence 77923 from Patent EP1572962. BC016846 - Homo sapiens deltex 3-like (Drosophila), mRNA (cDNA clone IMAGE:3912592). JD039983 - Sequence 21007 from Patent EP1572962. JD103253 - Sequence 84277 from Patent EP1572962. JD421357 - Sequence 402381 from Patent EP1572962. JD377487 - Sequence 358511 from Patent EP1572962. JD412462 - Sequence 393486 from Patent EP1572962. JD110868 - Sequence 91892 from Patent EP1572962. JD511656 - Sequence 492680 from Patent EP1572962. JD255757 - Sequence 236781 from Patent EP1572962. JD477143 - Sequence 458167 from Patent EP1572962. JD132771 - Sequence 113795 from Patent EP1572962. JD418647 - Sequence 399671 from Patent EP1572962. JD225053 - Sequence 206077 from Patent EP1572962. JD552764 - Sequence 533788 from Patent EP1572962. JD509605 - Sequence 490629 from Patent EP1572962. JD298753 - Sequence 279777 from Patent EP1572962. LF339137 - JP 2014500723-A/146640: Polycomb-Associated Non-Coding RNAs. JD274568 - Sequence 255592 from Patent EP1572962. JD087941 - Sequence 68965 from Patent EP1572962. JD264951 - Sequence 245975 from Patent EP1572962. JD174017 - Sequence 155041 from Patent EP1572962. JD324294 - Sequence 305318 from Patent EP1572962. JD059809 - Sequence 40833 from Patent EP1572962. JD156209 - Sequence 137233 from Patent EP1572962. JD255905 - Sequence 236929 from Patent EP1572962. JD480193 - Sequence 461217 from Patent EP1572962. AK025135 - Homo sapiens cDNA: FLJ21482 fis, clone COL05135. JD294949 - Sequence 275973 from Patent EP1572962. JD545946 - Sequence 526970 from Patent EP1572962. JD138371 - Sequence 119395 from Patent EP1572962. JD330329 - Sequence 311353 from Patent EP1572962. JD347738 - Sequence 328762 from Patent EP1572962. JD506021 - Sequence 487045 from Patent EP1572962. JD058680 - Sequence 39704 from Patent EP1572962. JD036661 - Sequence 17685 from Patent EP1572962. JD244175 - Sequence 225199 from Patent EP1572962. MA574714 - JP 2018138019-A/146640: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q8TDB6 (Reactome details) participates in the following event(s):
R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex R-HSA-983147 Release of E3 from polyubiquitinated substrate R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2 R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983169 Class I MHC mediated antigen processing & presentation R-HSA-1280218 Adaptive Immune System R-HSA-168256 Immune System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
