Human Gene DUSP11 (ENST00000272444.8_10) from GENCODE V47lift37
  Description: dual specificity phosphatase 11 (from RefSeq NM_003584.3)
Gencode Transcript: ENST00000272444.8_10
Gencode Gene: ENSG00000144048.12_14
Transcript (Including UTRs)
   Position: hg19 chr2:73,989,340-74,007,230 Size: 17,891 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr2:73,989,788-74,007,101 Size: 17,314 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:73,989,340-74,007,230)mRNA (may differ from genome)Protein (330 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: DUS11_HUMAN
DESCRIPTION: RecName: Full=RNA/RNP complex-1-interacting phosphatase; EC=3.1.3.-; AltName: Full=Dual specificity protein phosphatase 11; AltName: Full=Phosphatase that interacts with RNA/RNP complex 1;
FUNCTION: Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. Binds to RNA. May participate in nuclear mRNA metabolism.
SUBUNIT: Interacts with SFRS7 and SFRS9/SRP30C.
SUBCELLULAR LOCATION: Nucleus.
SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
SIMILARITY: Contains 1 tyrosine-protein phosphatase domain.
SEQUENCE CAUTION: Sequence=CAH10467.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: DUSP11
Diseases sorted by gene-association score: amyotrophic lateral sclerosis 1 (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.78 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 265.60 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -49.20129-0.381 Picture PostScript Text
3' UTR -92.20448-0.206 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000340 - Dual-sp_phosphatase_cat-dom
IPR000387 - Tyr/Dual-specificity_Pase
IPR016130 - Tyr_Pase_AS

Pfam Domains:
PF00782 - Dual specificity phosphatase, catalytic domain

SCOP Domains:
52799 - (Phosphotyrosine protein) phosphatases II

ModBase Predicted Comparative 3D Structure on O75319
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details  Gene Details  
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0004651 polynucleotide 5'-phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0098519 nucleotide phosphatase activity, acting on free nucleotides

Biological Process:
GO:0006396 RNA processing
GO:0006470 protein dephosphorylation
GO:0016070 RNA metabolic process
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0098507 polynucleotide 5' dephosphorylation

Cellular Component:
GO:0001650 fibrillar center
GO:0005634 nucleus
GO:0016607 nuclear speck
GO:0045171 intercellular bridge


-  Descriptions from all associated GenBank mRNAs
  BC000346 - Homo sapiens dual specificity phosphatase 11 (RNA/RNP complex 1-interacting), mRNA (cDNA clone MGC:8576 IMAGE:2960939), complete cds.
AF023917 - Homo sapiens protein tyrosine phosphatase PIR1 mRNA, complete cds.
JD441374 - Sequence 422398 from Patent EP1572962.
AK315271 - Homo sapiens cDNA, FLJ96281, Homo sapiens dual specificity phosphatase 11 (RNA/RNP complex1-interacting) (DUSP11), mRNA.
DQ891356 - Synthetic construct clone IMAGE:100003986; FLH176163.01X; RZPDo839A03122D dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) (DUSP11) gene, encodes complete protein.
DQ894537 - Synthetic construct Homo sapiens clone IMAGE:100008997; FLH176159.01L; RZPDo839A03121D dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) (DUSP11) gene, encodes complete protein.
CU674166 - Synthetic construct Homo sapiens gateway clone IMAGE:100018968 5' read DUSP11 mRNA.
CR627368 - Homo sapiens mRNA; cDNA DKFZp686N03270 (from clone DKFZp686N03270).
JD202455 - Sequence 183479 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RCT8, C9JYA6, DUS11_HUMAN, DUSP11 , ENST00000272444.1, ENST00000272444.2, ENST00000272444.3, ENST00000272444.4, ENST00000272444.5, ENST00000272444.6, ENST00000272444.7, NM_003584, O75319, PIR1, Q6AI47, Q9BWE3, uc317iza.1, uc317iza.2
UCSC ID: ENST00000272444.8_10
RefSeq Accession: NM_003584.3
Protein: O75319 (aka DUS11_HUMAN or DUSB_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.