ID:DUS26_HUMAN DESCRIPTION: RecName: Full=Dual specificity protein phosphatase 26; EC=3.1.3.16; EC=3.1.3.48; AltName: Full=Dual specificity phosphatase SKRP3; AltName: Full=Low-molecular-mass dual-specificity phosphatase 4; Short=DSP-4; Short=LDP-4; AltName: Full=Mitogen-activated protein kinase phosphatase 8; Short=MAP kinase phosphatase 8; Short=MKP-8; AltName: Full=Novel amplified gene in thyroid anaplastic cancer; FUNCTION: Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK). CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate. SUBUNIT: Interacts with HSF4. INTERACTION: P04637:TP53; NbExp=9; IntAct=EBI-2924519, EBI-366083; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Golgi apparatus. TISSUE SPECIFICITY: Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer. SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. SIMILARITY: Contains 1 tyrosine-protein phosphatase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BV47
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0001102 RNA polymerase II activating transcription factor binding GO:0002039 p53 binding GO:0004647 phosphoserine phosphatase activity GO:0004721 phosphoprotein phosphatase activity GO:0004725 protein tyrosine phosphatase activity GO:0005515 protein binding GO:0008138 protein tyrosine/serine/threonine phosphatase activity GO:0016787 hydrolase activity GO:0016791 phosphatase activity
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006470 protein dephosphorylation GO:0016311 dephosphorylation GO:0035335 peptidyl-tyrosine dephosphorylation GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation GO:0045785 positive regulation of cell adhesion GO:0070373 negative regulation of ERK1 and ERK2 cascade GO:1902310 positive regulation of peptidyl-serine dephosphorylation
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
