Human Gene DUSP28 (ENST00000343217.6_1) from GENCODE V47lift37
  Description: dual specificity phosphatase 28, transcript variant 2 (from RefSeq NM_001033575.1)
Gencode Transcript: ENST00000343217.6_1
Gencode Gene: ENSG00000188542.10_6
Transcript (Including UTRs)
   Position: hg19 chr2:241,499,471-241,503,431 Size: 3,961 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr2:241,500,102-241,500,884 Size: 783 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:241,499,471-241,503,431)mRNA (may differ from genome)Protein (176 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: DUS28_HUMAN
DESCRIPTION: RecName: Full=Dual specificity phosphatase 28; EC=3.1.3.16; EC=3.1.3.48;
CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate.
SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
SIMILARITY: Contains 1 tyrosine-protein phosphatase domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.10 RPKM in Testis
Total median expression: 127.98 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -250.60631-0.397 Picture PostScript Text
3' UTR -93.30393-0.237 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000340 - Dual-sp_phosphatase_cat-dom
IPR020422 - Dual-sp_phosphatase_subgr_cat
IPR024950 - DUSP
IPR000387 - Tyr/Dual-specificity_Pase

Pfam Domains:
PF00782 - Dual specificity phosphatase, catalytic domain

SCOP Domains:
52799 - (Phosphotyrosine protein) phosphatases II

ModBase Predicted Comparative 3D Structure on Q4G0W2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity

Biological Process:
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation


-  Descriptions from all associated GenBank mRNAs
  BC036198 - Homo sapiens dual specificity phosphatase 28, mRNA (cDNA clone MGC:39555 IMAGE:5298326), complete cds.
JD484944 - Sequence 465968 from Patent EP1572962.
JD173580 - Sequence 154604 from Patent EP1572962.
JD075707 - Sequence 56731 from Patent EP1572962.
JD395158 - Sequence 376182 from Patent EP1572962.
KJ895996 - Synthetic construct Homo sapiens clone ccsbBroadEn_05390 DUSP28 gene, encodes complete protein.
DL492210 - Novel nucleic acids.
JD194142 - Sequence 175166 from Patent EP1572962.
JD226716 - Sequence 207740 from Patent EP1572962.
JD538763 - Sequence 519787 from Patent EP1572962.
JD253197 - Sequence 234221 from Patent EP1572962.
JD076157 - Sequence 57181 from Patent EP1572962.
JD301187 - Sequence 282211 from Patent EP1572962.
JD306885 - Sequence 287909 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: DUS28_HUMAN, ENST00000343217.1, ENST00000343217.2, ENST00000343217.3, ENST00000343217.4, ENST00000343217.5, NM_001033575, Q4G0W2, uc317wou.1
UCSC ID: ENST00000343217.6_1
RefSeq Accession: NM_001033575.1
Protein: Q4G0W2 (aka DUS28_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.