ID:DYR1A_HUMAN DESCRIPTION: RecName: Full=Dual specificity tyrosine-phosphorylation-regulated kinase 1A; EC=2.7.12.1; AltName: Full=Dual specificity YAK1-related kinase; AltName: Full=HP86; AltName: Full=Protein kinase minibrain homolog; Short=MNBH; Short=hMNB; FUNCTION: May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. ENZYME REGULATION: Inhibited by RANBP9. SUBUNIT: Interacts RAD54L2/ARIP4 (By similarity). Interacts with RANBP9. Interacts with WDR68. INTERACTION: P31946:YWHAB; NbExp=3; IntAct=EBI-1053621, EBI-359815; SUBCELLULAR LOCATION: Nucleus speckle. TISSUE SPECIFICITY: Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney. DEVELOPMENTAL STAGE: Expressed in the developing central nervous system. Overexpressed 1.5-fold in fetal Down syndrome brain. DOMAIN: The polyhistidine repeats act as targeting signals to nuclear speckles (PubMed:19266028). PTM: Autophosphorylated on tyrosine residues. DISEASE: Defects in DYRK1A are the cause of mental retardation autosomal dominant type 7 (MRD7) [MIM:614104]. A disease characterized by primary microcephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. SIMILARITY: Contains 1 protein kinase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13627
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000381 regulation of alternative mRNA splicing, via spliceosome GO:0006468 protein phosphorylation GO:0007399 nervous system development GO:0007623 circadian rhythm GO:0016032 viral process GO:0016310 phosphorylation GO:0018105 peptidyl-serine phosphorylation GO:0018107 peptidyl-threonine phosphorylation GO:0018108 peptidyl-tyrosine phosphorylation GO:0031115 negative regulation of microtubule polymerization GO:0033120 positive regulation of RNA splicing GO:0034205 beta-amyloid formation GO:0036289 peptidyl-serine autophosphorylation GO:0038083 peptidyl-tyrosine autophosphorylation GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0046777 protein autophosphorylation GO:0048025 negative regulation of mRNA splicing, via spliceosome GO:0090312 positive regulation of protein deacetylation
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
