Human Gene DYRK1B (ENST00000323039.10_10) from GENCODE V47lift37
  Description: dual specificity tyrosine phosphorylation regulated kinase 1B, transcript variant 1 (from RefSeq NM_004714.3)
Gencode Transcript: ENST00000323039.10_10
Gencode Gene: ENSG00000105204.14_12
Transcript (Including UTRs)
   Position: hg19 chr19:40,315,990-40,324,802 Size: 8,813 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg19 chr19:40,316,355-40,322,507 Size: 6,153 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:40,315,990-40,324,802)mRNA (may differ from genome)Protein (629 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: DYR1B_HUMAN
DESCRIPTION: RecName: Full=Dual specificity tyrosine-phosphorylation-regulated kinase 1B; EC=2.7.12.1; AltName: Full=Minibrain-related kinase; AltName: Full=Mirk protein kinase;
FUNCTION: Dual-specificity kinase which possesses both serine/ threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
ENZYME REGULATION: Inhibited by RANBP9.
SUBUNIT: Dimer. Interacts with DCOHM, MAP2K3/MKK3, RANBP9 and TCF1/HNF1A. Part of a complex consisting of RANBP9, RAN, DYRK1B and COPS5. Interacts with DCAF7.
INTERACTION: P20823:HNF1A; NbExp=4; IntAct=EBI-634187, EBI-636034; P46734:MAP2K3; NbExp=2; IntAct=EBI-634187, EBI-602462; Q9H0N5:PCBD2; NbExp=2; IntAct=EBI-634187, EBI-634289; Q96S59:RANBP9; NbExp=4; IntAct=EBI-634187, EBI-636085;
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Highest expression in skeletal muscle, testis, heart and brain with little expression in colon or lung. Expressed in a variety of tumor cell lines.
PTM: Autophosphorylated on tyrosine residues. Phosphorylated by MAP kinase. Tyrosine phosphorylation may be required for dimerization.
SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
SIMILARITY: Contains 1 protein kinase domain.
SEQUENCE CAUTION: Sequence=AAC28914.1; Type=Erroneous gene model prediction;
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/DYRK1BID43235ch19q13.html";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: DYRK1B
Diseases sorted by gene-association score: abdominal obesity-metabolic syndrome 3* (1241), abdominal obesity-metabolic syndrome (41), chronic cervicitis (6), obesity (3)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 73.98 RPKM in Testis
Total median expression: 469.27 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -107.00241-0.444 Picture PostScript Text
3' UTR -171.80365-0.471 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine and serine/threonine kinase

SCOP Domains:
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on Q9Y463
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003713 transcription coactivator activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity

Biological Process:
GO:0006468 protein phosphorylation
GO:0007520 myoblast fusion
GO:0016310 phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0060612 adipose tissue development

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AF205861 - Homo sapiens protein kinase MIRK (MIRK) mRNA, complete cds.
BC025291 - Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B, mRNA (cDNA clone MGC:39237 IMAGE:5019417), complete cds.
BC018751 - Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B, mRNA (cDNA clone MGC:31947 IMAGE:4300012), complete cds.
Y17999 - Homo sapiens mRNA for protein kinase Dyrk1B.
AK074971 - Homo sapiens cDNA FLJ90490 fis, clone NT2RP3003527, highly similar to Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1).
AK302127 - Homo sapiens cDNA FLJ58809 complete cds, highly similar to Dual specificitytyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1).
JD131467 - Sequence 112491 from Patent EP1572962.
JD217184 - Sequence 198208 from Patent EP1572962.
JD218042 - Sequence 199066 from Patent EP1572962.
JD436850 - Sequence 417874 from Patent EP1572962.
KJ905372 - Synthetic construct Homo sapiens clone ccsbBroadEn_14931 DYRK1B gene, encodes complete protein.
DQ892536 - Synthetic construct clone IMAGE:100005166; FLH187257.01X; RZPDo839F0572D dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B (DYRK1B) gene, encodes complete protein.
DQ895747 - Synthetic construct Homo sapiens clone IMAGE:100010207; FLH187253.01L; RZPDo839F0562D dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B (DYRK1B) gene, encodes complete protein.
AB384881 - Synthetic construct DNA, clone: pF1KB3975, Homo sapiens DYRK1B gene for dual specificity tyrosine-phosphorylation-regulated kinase 1B, complete cds, without stop codon, in Flexi system.
BC009688 - Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B, mRNA (cDNA clone IMAGE:3900129), with apparent retained intron.
JD106451 - Sequence 87475 from Patent EP1572962.
DL492250 - Novel nucleic acids.
JD234000 - Sequence 215024 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_shhPathway - Sonic Hedgehog (Shh) Pathway

-  Other Names for This Gene
  Alternate Gene Symbols: DYR1B_HUMAN, ENST00000323039.1, ENST00000323039.2, ENST00000323039.3, ENST00000323039.4, ENST00000323039.5, ENST00000323039.6, ENST00000323039.7, ENST00000323039.8, ENST00000323039.9, MIRK, NM_004714, O75258, O75788, O75789, Q9Y463, uc317rjt.1, uc317rjt.2
UCSC ID: ENST00000323039.10_10
RefSeq Accession: NM_004714.3
Protein: Q9Y463 (aka DYR1B_HUMAN or DYRB_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.