ID:E2F8_HUMAN DESCRIPTION: RecName: Full=Transcription factor E2F8; Short=E2F-8; FUNCTION: Along with E2F7, inhibitor of E2F-dependent transcription. Binds DNA independently of DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Directly represses E2F1 transcription. Appears to regulate a subset of E2F-dependent genes whose products are required for normal cell cycle progession. SUBUNIT: Forms heterodimers with E2F7 and, to a lesser extent, homodimers. Dimerization is important for DNA binding. SUBCELLULAR LOCATION: Nucleus. DOMAIN: Both DNA-binding domains are required for DNA-binding and are proposed to form an intramolecular structure that is similar to the winged helix structure of the E2F-DP heterodimer (By similarity). SIMILARITY: Belongs to the E2F/DP family. SEQUENCE CAUTION: Sequence=AAH28244.2; Type=Erroneous initiation; Sequence=BAB15605.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on A0AVK6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
