ID:SYEM_HUMAN DESCRIPTION: RecName: Full=Probable glutamate--tRNA ligase, mitochondrial; EC=6.1.1.17; AltName: Full=Glutamyl-tRNA synthetase; Short=GluRS; Flags: Precursor; FUNCTION: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity). CATALYTIC ACTIVITY: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu). SUBCELLULAR LOCATION: Mitochondrion matrix (By similarity). SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00749 - tRNA synthetases class I (E and Q), catalytic domain PF19269 - Anticodon binding domain
SCOP Domains: 48163 - An anticodon-binding domain of class I aminoacyl-tRNA synthetases 52374 - Nucleotidylyl transferase
ModBase Predicted Comparative 3D Structure on Q5JPH6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
